> Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2)
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UGID:201337     UniGene Hs.375957     Homo sapiens (human)   ITGB2 Order cDNA clone, Links
Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2)

Human protein-coding gene ITGB2. Represented by 1146 ESTs from 202 cDNA libraries. EST representation biased toward neonate. Corresponds to 2 reference sequences (different isoforms). [UniGene 201337 - Hs.375957]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001029294.1 ITGB2 gene product P. troglodytes 100.0 768
NP_001120963.1 ITGB2 gene product H. sapiens 100.0 768
NP_032430.2 Itgb2 gene product M. musculus 89.5 769
NP_001080017.1 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) precursor X. laevis 69.1 770
XP_686012.3 PREDICTED: integrin beta-2-like D. rerio 57.7 759
NP_524793.2 myospheroid D. melanogaster 50.9 531
NP_497787.1 Protein PAT-3 C. elegans 48.8 297
Other hits (2 of 39) [Show all]SpeciesId(%)Len(aa)
XP_003895426.1 PREDICTED: integrin beta-2 isoform 1 P. anubis 96.1 768
NP_999073.1 ITGB2 gene product S. scrofa 91.2 768

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; thymus; blood; spleen; brain; connective tissue; placenta; lung; mixed; mammary gland; liver; prostate; uterus; embryonic tissue; bone marrow; kidney; muscle; ovary; adrenal gland; bladder; pharynx; intestine; testis; lymph node; tonsil; mouth; heart; thyroid; eye; stomach; bone; pancreas; cervix; trachea; esophagus; adipose tissue; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 21
Map position: 21q22.3
UniSTS entry: RH93593
UniSTS entry: Chr 21 G44333
UniSTS entry: Chr 21 GDB:181564
UniSTS entry: Chr 21 STS-M15395 [Map Viewer]
UniSTS entry: Chr 21 GDB:185175
UniSTS entry: Chr 21 G60035
UniSTS entry: Chr 21 GDB:373059
UniSTS entry: Chr 21 PMC129056P1
UniSTS entry: Chr 21 PMC129056P2
UniSTS entry: Chr 21 ITGB2_2800
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AK128344.1 Homo sapiens cDNA FLJ46486 fis, clone THYMU3026532, highly similar to Integrin beta-2 precursor P
NM_000211.3 Homo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 1, mRNA PA
BC021077.1 Homo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), mRNA (cDNA clone IMAGE:3532854), partial cds P
AK222505.1 Homo sapiens mRNA for integrin beta chain, beta 2 precursor variant, clone: adKA03436 P
M15395.1 Human leukocyte adhesion protein (LFA-1/Mac-1/p150,95 family) beta subunit mRNA P
BC005861.2 Homo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), mRNA (cDNA clone MGC:3628 IMAGE:3532902), complete cds PA
L78790.1 Homo sapiens integrin-like protein mRNA, complete cds P
Y00057.1 Human mRNA for beta-subunit of cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 P
NM_001127491.1 Homo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 2, mRNA PA
AK097864.1 Homo sapiens cDNA FLJ40545 fis, clone THYMU2001195
AK095992.1 Homo sapiens cDNA FLJ38673 fis, clone HSYRA2000792, highly similar to Integrin beta-2 precursor P
AK303488.1 Homo sapiens cDNA FLJ59807 complete cds, highly similar to Integrin beta-2 precursor PA

EST sequences (10 of 1146) [Show all sequences]

AA954710.1 Clone IMAGE:1572855 kidney 3' read A
AA962453.1 Clone IMAGE:1553590 kidney 3' read
AA975433.1 Clone IMAGE:1587705 uncharacterized tissue 3' read A
AA996018.1 Clone IMAGE:1606830 kidney 3' read A
AA907313.1 Clone IMAGE:1524050 mixed 3' read A
CB045710.1 Clone IMAGE:3218229 intestine 3' read A
CB045711.1 Clone IMAGE:3218229 intestine 5' read P
BX099934.1 Clone IMAGp998K21283_;_IMAGE:50503 brain A
BX107224.1 Clone IMAGp998N02782 heart 5' read
AI193726.1 Clone IMAGE:1744658 lung 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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