> Ferrochelatase (FECH)
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UGID:196945     UniGene Hs.365365     Homo sapiens (human)   FECH Order cDNA clone, Links
Ferrochelatase (FECH)

Human protein-coding gene FECH. Represented by 439 ESTs from 182 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 196945 - Hs.365365]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001012533.1 FECH gene product H. sapiens 100.0 428
XP_001085580.2 PREDICTED: ferrochelatase, mitochondrial isoform 1 M. mulatta 99.8 428
NP_001033101.1 FECH gene product P. troglodytes 99.8 422
XP_003914460.1 PREDICTED: ferrochelatase, mitochondrial P. anubis 99.5 422
NP_032024.2 ferrochelatase, mitochondrial M. musculus 93.8 421
NP_001081718.1 ferrochelatase, mitochondrial X. laevis 88.5 410
NP_571706.1 fech gene product D. rerio 83.8 381
XP_962504.1 ferrochelatase, mitochondrial precursor N. crassa 60.3 383
NP_524613.1 ferrochelatase, isoform A D. melanogaster 59.3 378
NP_014819.3 ferrochelatase HEM15 S. cerevisiae 54.1 344
Other hits (2 of 42) [Show all]SpeciesId(%)Len(aa)
XP_001488965.3 PREDICTED: ferrochelatase, mitochondrial-like, partial E. caballus 94.9 411
XP_852936.1 PREDICTED: ferrochelatase, mitochondrial C. lupus familiaris 94.7 398

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: mixed; brain; prostate; connective tissue; liver; testis; uncharacterized tissue; kidney; uterus; heart; lung; placenta; pancreas; stomach; eye; embryonic tissue; skin; blood; cervix; vascular; adrenal gland; bladder; mouth; esophagus; bone marrow; spleen; umbilical cord; intestine; mammary gland; muscle; thymus; ovary; lymph node; trachea; ascites; ear; thyroid; ganglia; bone; parathyroid; larynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 18
Map position: 18q21.3
UniSTS entry: Chr 18 WI-20204
UniSTS entry: Chr 18 STS-D00726
UniSTS entry: Chr 18 RH36328
UniSTS entry: Chr 18 D7S2739 [Map Viewer]
UniSTS entry: Chr 18 GDB:196608
UniSTS entry: Chr 18 RH102529
UniSTS entry: Chr 18 SHGC-79296
UniSTS entry: Chr 18 SHGC-81615
UniSTS entry: Chr 18 FECH__4993
UniSTS entry: Chr 1 D15S1390
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BX571744.1 Homo sapiens mRNA; cDNA DKFZp686P18130 (from clone DKFZp686P18130) PA
NM_000140.3 Homo sapiens ferrochelatase (FECH), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA P
BT019959.1 Homo sapiens ferrochelatase (protoporphyria) mRNA, complete cds P
BT019958.1 Homo sapiens ferrochelatase (protoporphyria) mRNA, complete cds P
NM_001012515.2 Homo sapiens ferrochelatase (FECH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA P
AK223190.1 Homo sapiens mRNA for Hypothetical protein DKFZp686P18130 variant, clone: REC00205 PA
D00726.1 Homo sapiens mRNA for ferrochelatase, complete cds P
AK292937.1 Homo sapiens cDNA FLJ76483 complete cds, highly similar to Homo sapiens ferrochelatase (protoporphyria) (FECH), mRNA P
AK092416.1 Homo sapiens cDNA FLJ35097 fis, clone PLACE6006222, highly similar to FERROCHELATASE PRECURSOR (EC 4.99.1.1) P
AK299643.1 Homo sapiens cDNA FLJ56930 complete cds, highly similar to Ferrochelatase, mitochondrial precursor (EC 4.99.1.1) P
BC039841.1 Homo sapiens ferrochelatase (protoporphyria), mRNA (cDNA clone MGC:48846 IMAGE:6042757), complete cds PA

EST sequences (10 of 439) [Show all sequences]

AA897645.1 Clone IMAGE:1503893 mixed 3' read PA
AA904548.1 Clone IMAGE:1507252 mixed 3' read A
AI022074.1 Clone IMAGE:1655044 mixed 3' read
AI032912.1 Clone IMAGE:1656797 mixed 3' read
AI033479.1 Clone IMAGE:1655497 mixed 3' read
AI038376.1 Clone IMAGE:1657006 mixed 3' read A
AI073600.1 Clone IMAGE:1665113 skin 3' read A
AI078641.1 Clone IMAGE:1667902 parathyroid 3' read
AI088364.1 Clone IMAGE:1695567 uterus 3' read A
AI129341.1 Clone IMAGE:1712837 uterus 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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