> Dihydropyrimidine dehydrogenase (DPYD)
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UGID:190763     UniGene Hs.335034     Homo sapiens (human)   DPYD Order cDNA clone, Links
Dihydropyrimidine dehydrogenase (DPYD)

Human protein-coding gene DPYD. Represented by 165 ESTs from 103 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 190763 - Hs.335034]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000101.2 DPYD gene product H. sapiens 100.0 1024
XP_513583.3 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform 3 P. troglodytes 99.9 1024
NP_740748.1 Dpyd gene product M. musculus 92.0 1024
NP_001087488.1 dihydropyrimidine dehydrogenase X. laevis 86.3 939
NP_998058.1 dpydb gene product D. rerio 82.2 1021
NP_572538.1 suppressor of rudimentary, isoform B D. melanogaster 71.5 1012
NP_508927.2 Protein DPYD-1 C. elegans 69.9 1030
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_001106007.1 PREDICTED: dihydropyrimidine dehydrogenase [NADP+] M. mulatta 99.0 1024
XP_003892289.1 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)], partial P. anubis 98.8 775

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; eye; prostate; embryonic tissue; brain; testis; pharynx; liver; mixed; uterus; mouth; intestine; placenta; lung; kidney; pancreas; larynx; skin; bone marrow; heart; blood; connective tissue; lymph node; muscle; bone; thyroid; mammary gland; spleen; trachea; lymph; cervix; nerve; ganglia; ovary; thymus; vascular; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1p22
UniSTS entry: Chr 1 SHGC-132118
UniSTS entry: Chr 1 SHGC-12941 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

BT006740.1 Homo sapiens dihydropyrimidine dehydrogenase mRNA, complete cds P
NM_000110.3 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA P
BC064027.1 Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone IMAGE:6173084), complete cds PA
AB003063.1 Homo sapiens mRNA for dihydropyrimidine dehydrogenase, complete cds P
U09178.1 Human dihydropyrimidine dehydrogenase mRNA, complete cds P
BC108742.1 Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone IMAGE:6500607), complete cds PA
U20938.1 Human lymphocyte dihydropyrimidine dehydrogenase mRNA, complete cds P
BC008379.1 Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone IMAGE:3932367), complete cds PA
BC131778.1 Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone MGC:156280 IMAGE:40123878), complete cds P
BC131777.1 Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone MGC:156279 IMAGE:40123875), complete cds P
AK291217.1 Homo sapiens cDNA FLJ76825 complete cds, highly similar to Homo sapiens dihydropyrimidine dehydrogenase (DPYD), mRNA P
AK297515.1 Homo sapiens cDNA FLJ53741 complete cds, moderately similar to Dihydropyrimidine dehydrogenase [NADP+] precursor (EC 1.3.1.2) P
NM_001160301.1 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA P

EST sequences (10 of 165) [Show all sequences]

AA993324.1 Clone IMAGE:1618236 testis 3' read A
AI124948.1 Clone IMAGE:1726491 vascular 3' read A
CB049728.1 Clone IMAGE:3271495 prostate 3' read
CB049729.1 Clone IMAGE:3271495 prostate 5' read
CB067478.1 Clone IMAGE: pancreas 3' read A
CB067775.1 Clone IMAGE: pancreas 5' read P
AI168714.1 Clone IMAGE:1661270 mixed 3' read A
CB113489.1 Clone L3SNU475s1-3-G02 liver 5' read
CB113249.1 Clone L6ChoCK0-12-B02 liver 5' read
AI473709.1 Clone IMAGE:2044340 lymph node 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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