> Secreted phosphoprotein 1 (SPP1)
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UGID:130729     UniGene Hs.313     Homo sapiens (human)   SPP1 Order cDNA clone, Links
Secreted phosphoprotein 1 (SPP1)

Human protein-coding gene SPP1. Represented by 2435 ESTs from 341 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 130729 - Hs.313]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001238759.1 SPP1 gene product H. sapiens 100.0 326
NP_001191130.1 Spp1 gene product M. musculus 70.0 309
Other hits (2 of 12) [Show all]SpeciesId(%)Len(aa)
XP_003950417.1 PREDICTED: osteopontin P. troglodytes 99.4 326
XP_002804172.1 PREDICTED: osteopontin isoform 2 M. mulatta 96.2 313

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; kidney; placenta; uncharacterized tissue; pancreas; embryonic tissue; lung; eye; mixed; liver; blood; bone; uterus; ear; connective tissue; cervix; spleen; skin; muscle; thyroid; testis; trachea; bladder; larynx; mammary gland; prostate; adrenal gland; umbilical cord; adipose tissue; mouth; stomach; ovary; intestine; bone marrow; spinal cord; pharynx; esophagus; heart; amniotic fluid; vascular; ganglia; pineal gland; nerve; thymus; lymph node; tonsil
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4q22.1
UniSTS entry: Chr 4 PMC351321P4
UniSTS entry: Chr 4 D4S3132 [Map Viewer]
UniSTS entry: Chr 4 SHGC4-1078 [Map Viewer]
UniSTS entry: Chr 4 SHGC-36594
UniSTS entry: Chr 4 SHGC-59479 [Map Viewer]
UniSTS entry: Chr 4 SPP1_3239
UniSTS entry: AB055366
UniSTS entry: Chr 1 sY3084
UniSTS entry: Ndufb11
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (33)

AF052124.1 Homo sapiens clone 23810 osteopontin mRNA, complete cds PA
BX648003.1 Homo sapiens mRNA; cDNA DKFZp686G0159 (from clone DKFZp686G0159) PA
NM_000582.2 Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 2, mRNA PA
AY956318.1 Homo sapiens osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein (SPP1/CALPHA1 fusion) mRNA, partial cds
BC093033.1 Homo sapiens secreted phosphoprotein 1, mRNA (cDNA clone MGC:110940 IMAGE:5288027), complete cds PA
AB209987.1 Homo sapiens opn mRNA for osteopontin, partial cds P
J04765.1 Human osteopontin mRNA, complete cds P
NM_001040058.1 Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 1, mRNA PA
NM_001040060.1 Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 3, mRNA PA
BC007016.1 Homo sapiens secreted phosphoprotein 1, mRNA (cDNA clone MGC:12351 IMAGE:4052438), complete cds PA
X13694.1 Human mRNA for osteopontin P
DQ846871.1 Homo sapiens clone BFC06121 secreted phosphoprotein 1 mRNA, complete cds P
DQ846870.1 Homo sapiens clone BFC06119 secreted phosphoprotein 1 mRNA, complete cds P
DQ839491.1 Homo sapiens clone BFC06011 secreted phosphoprotein 1 mRNA, complete cds P
BC017387.1 Homo sapiens secreted phosphoprotein 1, mRNA (cDNA clone MGC:22826 IMAGE:3828885), complete cds PA
AK057738.1 Homo sapiens cDNA FLJ25009 fis, clone CBL01101, highly similar to OSTEOPONTIN PRECURSOR P
AK290104.1 Homo sapiens cDNA FLJ78337 complete cds, highly similar to Homo sapiens secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), transcript variant 1, mRNA P
AK290090.1 Homo sapiens cDNA FLJ77801 complete cds P
M83248.1 Homo sapiens nephropontin precursor, mRNA, complete cds P
AK315461.1 Homo sapiens cDNA, FLJ96520, Homo sapiens secreted phosphoprotein 1 (osteopontin, bonesialoprotein I, early T-lymphocyte activation 1) (SPP1), mRNA P
BC022844.1 Homo sapiens secreted phosphoprotein 1, mRNA (cDNA clone MGC:24777 IMAGE:4284921), complete cds PA
AK296035.1 Homo sapiens cDNA FLJ52507 complete cds, highly similar to Osteopontin precursor P
AK075463.1 Homo sapiens cDNA PSEC0156 fis, clone PLACE1008107, highly similar to Human osteopontin gene P
AB019562.1 Homo sapiens mRNA expressed only in placental villi, clone SMAP41
D28761.1 Homo sapiens mRNA for OPN-c, partial cds P
D28760.1 Homo sapiens mRNA for OPN-b, partial cds P
D28759.1 Homo sapiens mRNA for OPN-a, partial cds P
AK295491.1 Homo sapiens cDNA FLJ54682 complete cds, highly similar to Osteopontin precursor PA
AB469789.1 Homo sapiens opn mRNA for osteopontin, partial cds P
HQ874461.1 Homo sapiens osteopontin-D mRNA, partial cds, alternatively spliced
HQ874460.1 Homo sapiens osteopontin-C mRNA, partial cds, alternatively spliced
NM_001251830.1 Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 5, mRNA PA
NM_001251829.1 Homo sapiens secreted phosphoprotein 1 (SPP1), transcript variant 4, mRNA PA

EST sequences (10 of 2435) [Show all sequences]

AA968537.1 Clone IMAGE:1592157 kidney 3' read A
AA976060.1 Clone IMAGE:1558403 lung 3' read A
AA991239.1 Clone IMAGE:1607858 mammary gland 3' read A
R18015.1 Clone IMAGE:124996 mixed 5' read
R18197.1 Clone IMAGE:30768 brain 5' read
AA922631.1 Clone IMAGE:1550588 uncharacterized tissue 3' read A
AI042223.1 Clone IMAGE:1660755 mixed 3' read A
R19704.1 Clone IMAGE:34283 brain 5' read
R20175.1 Clone IMAGE:34533 brain 5' read
R21504.1 Clone IMAGE:130152 placenta 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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