Lysyl-tRNA synthetase (KARS)

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UGID:131351 UniGene Hs.3100 Homo sapiens (human) KARS

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Lysyl-tRNA synthetase (KARS)

Human protein-coding gene KARS. Represented by 994 ESTs from 328 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 131351 - Hs.3100]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_003315273.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: lysine--tRNA ligase isoform 1	P. troglodytes	100.0	624
NP_001123561.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	KARS gene product	H. sapiens	100.0	624
NP_001124340.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Kars gene product	M. musculus	97.3	623
NP_001002386.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	kars gene product	D. rerio	90.5	597
NP_001080633.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lysyl-tRNA synthetase	X. laevis	90.2	604
NP_727353.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Lysyl-tRNA synthetase, isoform B	D. melanogaster	80.4	606
NP_495453.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein KARS-1, isoform a	C. elegans	73.4	567
XP_001697493.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lysyl-trna synthetase, LysRS	C. reinhardtii	71.7	575
NP_010322.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lysine--tRNA ligase KRS1	S. cerevisiae	69.4	578
NP_187777.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Lysyl-tRNA synthetase	A. thaliana	67.9	607
XP_957635.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	lysyl-tRNA synthetase	N. crassa	60.9	581
Other hits (2 of 63) [Show all]		Species	Id(%)	Len(aa)
XP_003917247.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: lysine--tRNA ligase isoform 2	P. anubis	98.9	624
XP_001104312.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: lysyl-tRNA synthetase isoform 1	M. mulatta	98.7	624

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; testis; uncharacterized tissue; eye; lung; intestine; ascites; embryonic tissue; skin; placenta; mixed; uterus; mammary gland; liver; prostate; bone marrow; thyroid; kidney; cervix; lymph; ovary; stomach; pancreas; lymph node; blood; tonsil; bladder; bone; heart; connective tissue; muscle; mouth; adrenal gland; pituitary gland; larynx; esophagus; pharynx; salivary gland; adipose tissue; nerve; ganglia; vascular; umbilical cord; thymus; parathyroid

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	16
Map position:	16q23.1
UniSTS entry:	Chr 16	SHGC-61037	[Map Viewer]
UniSTS entry:	Chr 16	D16S2968	[Map Viewer]
UniSTS entry:	Chr 13	SHGC-61044	[Map Viewer]
UniSTS entry:	Chr 13	MARC_13466-13467:1002299828:1

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AK126584.1	Homo sapiens cDNA FLJ44621 fis, clone BRACE2016896, highly similar to Lysyl-tRNA synthetase (EC 6.1.1.6)	P
NM_005548.2	Homo sapiens lysyl-tRNA synthetase (KARS), transcript variant 2, mRNA	P
AF285758.1	Homo sapiens lysyl-tRNA synthetase mRNA, complete cds; nuclear gene for mitochondrial product; alternatively spliced	P
BC004132.2	Homo sapiens lysyl-tRNA synthetase, mRNA (cDNA clone MGC:1404 IMAGE:2963032), complete cds	PA
AK309168.1	Homo sapiens cDNA, FLJ99209	P
AK315687.1	Homo sapiens cDNA, FLJ96785	P
NM_001130089.1	Homo sapiens lysyl-tRNA synthetase (KARS), transcript variant 1, mRNA	P
BC013246.1	Homo sapiens lysyl-tRNA synthetase, mRNA (cDNA clone IMAGE:4339500)	PA
D31890.1	Homo sapiens KIAA0070 mRNA, partial cds	P
D32053.1	Homo sapiens mRNA for Lysyl tRNA Synthetase, complete cds	P

EST sequences (10 of 994) [Show all sequences]

AA954213.1	Clone IMAGE:1575110	kidney	3' read	P
AA970759.1	Clone IMAGE:1576466	intestine	3' read	PA
AA974496.1	Clone IMAGE:1372142	lymph node	3' read	P
AA976734.1	Clone IMAGE:1585573	lung	3' read
AA976735.1	Clone IMAGE:1585575	lung	3' read	P
AA977448.1	Clone IMAGE:1591152	kidney	3' read
AA985162.1	Clone IMAGE:1629290	brain	3' read	P
AI002294.1	Clone IMAGE:1593245	kidney	3' read	P
R18803.1	Clone IMAGE:32966	brain	5' read	P
AI039385.1	Clone IMAGE:1658798	embryonic tissue	3' read	PA

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria