Mediator complex subunit 8 (MED8)

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UGID:181277 UniGene Hs.301756 Homo sapiens (human) MED8

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Mediator complex subunit 8 (MED8)

Human protein-coding gene MED8. Represented by 312 ESTs from 163 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 181277 - Hs.301756]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_443109.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator of RNA polymerase II transcription subunit 8 isoform 3	H. sapiens	100.0	300
XP_003308080.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 8-like	P. troglodytes	100.0	267
XP_003891772.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 8	P. anubis	99.7	300
NP_064384.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator of RNA polymerase II transcription subunit 8 isoform 1	M. musculus	98.9	267
NP_001088933.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator of RNA polymerase II transcription subunit 8-A	X. laevis	84.3	267
NP_996966.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	med8 gene product	D. rerio	73.6	264
NP_722456.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mediator complex subunit 8	D. melanogaster	48.6	208
Other hits (2 of 31) [Show all]		Species	Id(%)	Len(aa)
XP_001498553.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 8-like isoform 1	E. caballus	99.2	267
XP_853421.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: mediator of RNA polymerase II transcription subunit 8	C. lupus familiaris	98.9	267

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; liver; mixed; blood; uncharacterized tissue; testis; uterus; mammary gland; stomach; pancreas; bladder; connective tissue; embryonic tissue; intestine; bone; eye; kidney; pituitary gland; placenta; skin; heart; lung; ovary; prostate; larynx; salivary gland; muscle; cervix; vascular; lymph; ascites; thymus; thyroid

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	1
Map position:	1p34.2
UniSTS entry:	Chr 1	D1S1808E	[Map Viewer]
UniSTS entry:	Chr 1	RH15983
UniSTS entry:		D1S3519

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

NM_201542.4	Homo sapiens mediator complex subunit 8 (MED8), transcript variant 5, mRNA	PA
NM_001001653.2	Homo sapiens mediator complex subunit 8 (MED8), transcript variant 4, mRNA	A
BC010543.1	Homo sapiens mediator complex subunit 8, mRNA (cDNA clone IMAGE:3462146), partial cds	PA
BC010019.2	Homo sapiens mediator complex subunit 8, mRNA (cDNA clone MGC:19641 IMAGE:2905623), complete cds	PA
NM_052877.4	Homo sapiens mediator complex subunit 8 (MED8), transcript variant 3, mRNA	PA
AF521562.1	Homo sapiens mediator of RNA polymerase II transcription subunit MED8 mRNA, complete cds	P

EST sequences (10 of 312) [Show all sequences]

AI025595.1	Clone IMAGE:1644327	testis	3' read
AI049852.1	Clone IMAGE:1699323	kidney	3' read	A
R20450.1	Clone IMAGE:34438	brain	5' read
AI128521.1	Clone IMAGE:1714133	placenta	3' read	A
AI138246.1	Clone IMAGE:1735429	testis	3' read
AI188078.1	Clone IMAGE:1734322	testis	3' read	A
AI205948.1	Clone IMAGE:1762208	kidney	3' read	A
CB161514.1	Clone L17N670205n1-34-F03	liver	5' read
CB162354.1	Clone L17N670205n1-42-F12	liver	5' read
AI277076.1	Clone IMAGE:1874850	intestine	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria