Orthodenticle homeobox 2 (OTX2)

Restricted Expression:

eye [show more like this]

retinoblastoma [show more like this]

blastocyst [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

eye; brain; embryonic tissue; mixed; uncharacterized tissue; pineal gland

NCBI

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Finding cDNAs

UGID:178376 UniGene Hs.288655 Homo sapiens (human) OTX2

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Orthodenticle homeobox 2 (OTX2)

Human protein-coding gene OTX2. Represented by 45 ESTs from 18 cDNA libraries. EST representation biased toward eye; retinoblastoma; blastocyst. Corresponds to 6 reference sequences (different isoforms). [UniGene 178376 - Hs.288655]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_003751504.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein OTX2-like isoform 2	R. norvegicus	100.0	296
XP_003901901.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein OTX2	P. anubis	100.0	296
XP_001163043.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: uncharacterized protein LOC452927 isoform 2	P. troglodytes	100.0	296
NP_068374.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	OTX2 gene product	H. sapiens	100.0	296
XP_003435187.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein OTX2	C. lupus familiaris	99.7	296
NP_659090.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Otx2 gene product	M. musculus	99.7	288
NP_571326.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	otx2 gene product	D. rerio	94.8	288
NP_001084955.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	homeobox protein OTX2-B	X. laevis	94.8	288
Other hits (2 of 24) [Show all]		Species	Id(%)	Len(aa)
NP_001171116.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	orthodenticle homeobox 2	M. mulatta	99.3	296
XP_001496380.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: homeobox protein OTX2-like isoform 2	E. caballus	99.3	296

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	14
Map position:	14q22.3
UniSTS entry:	Chr 14	PMC263842P1
UniSTS entry:	Chr 14	PMC304098P1
UniSTS entry:		Otx2
UniSTS entry:	Chr 14	Otx2
UniSTS entry:	Chr 14	A005E27	[Map Viewer]
UniSTS entry:	Chr 14	RH68366	[Map Viewer]
UniSTS entry:	Chr 14	Otx2
UniSTS entry:	Chr 14	OTX2_V273
UniSTS entry:		Otx2

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

AF093138.1	Homo sapiens homeodomain protein OTX2 (OTX2) mRNA, complete cds	P
NM_021728.3	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA	PA
AK314271.1	Homo sapiens cDNA, FLJ95024, Homo sapiens orthodenticle homolog 2 (Drosophila) (OTX2),transcript variant 2, mRNA	P
BC032579.1	Homo sapiens orthodenticle homeobox 2, mRNA (cDNA clone MGC:45000 IMAGE:5493541), complete cds	PA
AB593058.1	Homo sapiens OTX2 mRNA for homeobox protein OTX2, complete cds, clone: HP05226-RBdS105G21	P
AB593057.1	Homo sapiens OTX2 mRNA for homeobox protein OTX2, complete cds, clone: HP05226-RBdS104I06	P
NR_073034.1	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 6, non-coding RNA	PA
NM_001270524.1	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 4, mRNA	PA
NM_001270525.1	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 5, mRNA	PA
NM_001270523.1	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 3, mRNA	PA
NM_172337.2	Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 2, mRNA	PA

EST sequences (10 of 45) [Show all sequences]

BX099386.1	Clone IMAGp998J15270_;_IMAGE:45153	brain
AW953935.1		uncharacterized tissue
CN335600.1		embryonic tissue	5' read
H08155.1	Clone IMAGE:45153	brain	3' read	A
H17803.1	Clone IMAGE:50354	brain	5' read
H17804.1	Clone IMAGE:50354	brain	3' read	A
CV030751.1		mixed	5' read	P
CX165126.1	Clone IMAGE:7468695	embryonic tissue	5' read	P
BE618045.1	Clone IMAGE:3865754	eye	5' read	P
BE618594.1	Clone IMAGE:3865754	eye	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria