Methionine adenosyltransferase I, alpha (MAT1A)

Restricted Expression:

fetus [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

liver; mixed; testis; uncharacterized tissue; blood; spleen; mammary gland; lymph; thymus; brain; heart; skin; eye; intestine; stomach; thyroid; pancreas; lung

NCBI

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Finding cDNAs

UGID:176273 UniGene Hs.282670 Homo sapiens (human) MAT1A

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Methionine adenosyltransferase I, alpha (MAT1A)

Human protein-coding gene MAT1A. Represented by 150 ESTs from 41 cDNA libraries. EST representation biased toward fetus. Corresponds to reference sequence NM_000429.2. [UniGene 176273 - Hs.282670]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_507874.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: s-adenosylmethionine synthase isoform type-1	P. troglodytes	100.0	394
NP_000420.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	MAT1A gene product	H. sapiens	100.0	394
NP_598414.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Mat1a gene product	M. musculus	97.5	395
NP_001080175.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	methionine adenosyltransferase II, alpha	X. laevis	88.1	395
NP_956165.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	mat1a gene product	D. rerio	88.1	379
NP_500872.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein SAMS-3, isoform a	C. elegans	77.7	381
NP_722594.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	S-adenosylmethionine synthetase, isoform A	D. melanogaster	77.1	402
NP_013281.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	methionine adenosyltransferase SAM1	S. cerevisiae	73.4	379
XP_965430.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	S-adenosylmethionine synthetase	N. crassa	72.8	382
NP_188365.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	S-adenosylmethionine synthase 4	A. thaliana	65.5	383
XP_001696661.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	S-Adenosylmethionine synthetase	C. reinhardtii	64.5	383
Other hits (2 of 64) [Show all]		Species	Id(%)	Len(aa)
XP_001087977.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: s-adenosylmethionine synthase isoform type-1	M. mulatta	98.7	395
XP_003903747.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: S-adenosylmethionine synthase isoform type-1	P. anubis	98.7	395

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	10
Map position:	10q22
UniSTS entry:	Chr 10	RH1570	[Map Viewer]
UniSTS entry:	Chr 10	G15884
UniSTS entry:	Chr 10	MAT1A

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

NM_000429.2	Homo sapiens methionine adenosyltransferase I, alpha (MAT1A), mRNA	PA
AK026931.1	Homo sapiens cDNA: FLJ23278 fis, clone HEP05402, highly similar to HSSAMAA Homo sapiens mRNA for S-adenosylmethionine synthetase	PA
D49357.1	Homo sapiens mRNA for S-adenosylmethionine synthetase, complete cds	P
BC018359.1	Homo sapiens methionine adenosyltransferase I, alpha, mRNA (cDNA clone MGC:17089 IMAGE:4341915), complete cds	PA
AK290820.1	Homo sapiens cDNA FLJ76034 complete cds, highly similar to Homo sapiens methionine adenosyltransferase I, alpha (MAT1A), mRNA	P
X69078.1	H.sapiens mRNA for S-adenosylmethionine synthetase	PA

EST sequences (10 of 150) [Show all sequences]

AI018328.1	Clone IMAGE:1626857	mixed	3' read	A
AI040981.1	Clone IMAGE:1641779	testis	3' read	A
AI144381.1	Clone IMAGE:1705735	heart	3' read	A
AI184830.1	Clone IMAGE:1731910	heart	3' read	A
CB115401.1	Clone L7N800102-10-E02	liver	5' read	P
AI201376.1	Clone IMAGE:1755489	testis	3' read	A
AI242113.1	Clone IMAGE:1854424	mixed	3' read	A
BX119626.1	Clone IMAGp998H01660_;_IMAGE:295728	mixed
AI808037.1	Clone IMAGE:2359270	mixed	3' read	A
BX365506.2	Clone CS0DJ008YA06	blood	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria