> Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL)
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UGID:171638     UniGene Hs.258855     Homo sapiens (human)   MLL Links
Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL)

Human protein-coding gene MLL. Represented by 612 ESTs from 262 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 171638 - Hs.258855]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001184033.1 MLL gene product H. sapiens 100.0 3971
XP_508792.2 PREDICTED: histone-lysine N-methyltransferase MLL P. troglodytes 99.9 3968
XP_003910832.1 PREDICTED: histone-lysine N-methyltransferase MLL P. anubis 99.6 3967
XP_001093874.2 PREDICTED: histone-lysine N-methyltransferase MLL M. mulatta 99.6 3859
NP_001074518.1 Mll1 gene product M. musculus 95.2 3962
NP_001085287.1 uncharacterized protein LOC443634 X. laevis 79.8 94
NP_476770.1 trithorax, isoform B D. melanogaster 64.2 292
NP_001103749.1 mll gene product D. rerio 59.5 4217
NP_498041.1 Protein SET-2, isoform b C. elegans 54.9 143
NP_194520.3 histone-lysine N-methyltransferase ATX4 A. thaliana 49.7 152
Other hits (2 of 51) [Show all]SpeciesId(%)Len(aa)
XP_001492012.2 PREDICTED: septin-6-like isoform 2 E. caballus 97.9 94
XP_002720170.1 PREDICTED: septin 6-like O. cuniculus 97.9 94

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; lymph node; uncharacterized tissue; mixed; lung; intestine; embryonic tissue; mammary gland; pancreas; liver; testis; placenta; prostate; uterus; eye; ovary; stomach; vascular; thymus; muscle; bone; pineal gland; thyroid; trachea; blood; kidney; larynx; heart; parathyroid; skin; pharynx; adrenal gland; bladder; connective tissue; cervix; ascites; lymph; nerve; bone marrow; mouth; ganglia; umbilical cord
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11q23
UniSTS entry: Chr 11 RH16534
UniSTS entry: Chr 11 RH44274
UniSTS entry: Chr 11 RH48277
UniSTS entry: Chr 11 STS-T67449
UniSTS entry: Chr 11 RH65355
UniSTS entry: Chr 11 STS-AA009746
UniSTS entry: Chr 11 STS-H92945
UniSTS entry: Chr 11 MARC_12741-12742:1029349377:1
UniSTS entry: Mll1
UniSTS entry: Chr 11 MLL1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (43)

AY187945.1 Homo sapiens transcription factor MLL UPN95022 mRNA, partial cds; alternatively spliced P
AY187944.1 Homo sapiens transcription factor MLL UPN95022 mRNA, partial cds; alternatively spliced P
AY187943.1 Homo sapiens transcription factor MLL UPN96240 mRNA, partial cds; alternatively spliced P
AY187942.1 Homo sapiens transcription factor MLL UPN96240 mRNA, partial cds; alternatively spliced
BX537782.1 Homo sapiens mRNA; cDNA DKFZp779C158 (from clone DKFZp779C158) A
NM_005933.3 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 2, mRNA P
BC065385.1 Homo sapiens cDNA clone IMAGE:6194897, partial cds A
BC090876.1 Homo sapiens cDNA clone IMAGE:30530192 A
AB209508.1 Homo sapiens mRNA for myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) variant protein P
AK021845.1 Homo sapiens cDNA FLJ11783 fis, clone HEMBA1006005
L04284.1 Human germline HRX mRNA, complete cds P
BC127775.1 Homo sapiens cDNA clone IMAGE:40133761
BC015388.1 Homo sapiens, clone IMAGE:4401491, mRNA A
AF512944.1 Homo sapiens clone 1838-14 MLL/SEPTIN6 fusion protein mRNA, partial cds P
FM165199.1 Homo sapiens partial mRNA for MLL-TET1 fusion transcript in acute lymphoblastic leukemia, patient 4765
FM165198.1 Homo sapiens partial mRNA for TET1-MLL fusion transcript in acute lymphoblastic leukemia, patient 4765 P
FM165196.1 Homo sapiens partial mRNA for MLL-TET1 fusion transcript in acute lymphoblastic leukemia, patient 3811
AK303179.1 Homo sapiens cDNA FLJ56868 partial cds, highly similar to Zinc finger protein HRX P
AK295635.1 Homo sapiens cDNA FLJ56846 complete cds, highly similar to Zinc finger protein HRX P
D14540.1 Homo sapiens mRNA for MLL, partial cds P
AF487906.1 Homo sapiens AF4/MLL fusion protein mRNA, partial cds P
AF272382.1 Homo sapiens clone 1370-39 MLL protein mRNA, partial cds P
AF272381.1 Homo sapiens clone 1370-7 MLL protein mRNA, partial cds P
AF272380.1 Homo sapiens clone 1370-23 MLL protein mRNA, partial cds P
AF272379.1 Homo sapiens clone 1370-10 aberrant MLL protein transcript, partial sequence P
AF272378.1 Homo sapiens clone 1370-57 MLL protein mRNA, partial cds P
AF272377.1 Homo sapiens clone 1370-48 MLL protein mRNA, partial cds
AF272373.1 Homo sapiens clone 1373-13 aberrant MLL/ELL fusion protein transcript, partial sequence
AF272372.1 Homo sapiens clone 1373-24 aberrant MLL protein transcript, partial sequence
AF272370.1 Homo sapiens clone 1373-28 MLL protein mRNA, partial cds P
AF232001.1 Homo sapiens MLL protein (MLL) mRNA, partial cds P
AF232000.1 Homo sapiens MLL protein (MLL) mRNA, partial cds P
AF024540.1 Homo sapiens rearranged MLL protein mRNA, partial cds
S78571.1 MLL {14p-18A} [human, mRNA Partial, 114 nt]
S78570.1 MLL=trx zinc-finger domain homolog {alternatively spliced, clone 14p-18B} [human, mRNA Partial, 1098 nt] P
S66432.1 MLL {translocation} [human, mRNA PartialMutant, 360 nt] P
L01986.1 Human trithorax-like protein (TRX1) mRNA, partial cds P
L04731.1 Homo sapiens translocation T(4:11) of ALL-1 gene to chromosome 4 P
NM_001197104.1 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 1, mRNA P
JN169752.1 Homo sapiens MLL/AF4 fusion protein (MLL/AF4 fusion) mRNA, partial cds P
JF938535.1 Homo sapiens MLL/LOC100131626 fusion gene isoform 1, mRNA sequence
JF938536.1 Homo sapiens MLL/LOC100131626 fusion gene isoform 2, mRNA sequence
BC039603.1 Homo sapiens, clone IMAGE:6062880, mRNA A

EST sequences (10 of 612) [Show all sequences]

AA960893.1 Clone IMAGE:1564108 mixed 3' read
AA969422.1 Clone IMAGE:1580551 mixed 3' read P
AA974861.1 Clone IMAGE:1567743 lung 3' read
T05548.1 Clone HFBDC18 brain P
AA988109.1 Clone IMAGE:1604638 lung 3' read P
AA988216.1 Clone IMAGE:1604666 lung 3' read
AA922844.1 Clone IMAGE:1457359 intestine 3' read
AA946699.1 Clone IMAGE:1372196 lymph node 3' read P
AI002656.1 Clone IMAGE:1629149 mixed 3' read P
T05749.1 Clone HFBDF78 brain P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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