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UGID:134507     UniGene Hs.22654     Homo sapiens (human)   SCN1A
Sodium channel, voltage-gated, type I, alpha subunit (SCN1A)

Human protein-coding gene SCN1A. Represented by 49 ESTs from 20 cDNA libraries. EST representation biased toward normal; infant. Corresponds to 4 reference sequences (different isoforms). [UniGene 134507 - Hs.22654]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001159435.1 SCN1A gene product H. sapiens 100.0 2008
XP_003309330.1 PREDICTED: sodium channel protein type 1 subunit alpha P. troglodytes 100.0 2008
XP_001101023.1 PREDICTED: sodium channel protein type 2 subunit alpha isoform 2 M. mulatta 99.8 2007
XP_003907609.1 PREDICTED: sodium channel protein type 1 subunit alpha isoform 1 P. anubis 99.8 2007
NP_061203.2 sodium channel, voltage-gated, type I, alpha M. musculus 98.7 1997
NP_001038360.1 scn1lab gene product D. rerio 80.7 1989
NP_001188645.1 paralytic, isoform AX D. melanogaster 50.6 1954
Other hits (2 of 36) [Show all]SpeciesId(%)Len(aa)
XP_001916728.2 PREDICTED: LOW QUALITY PROTEIN: sodium channel protein type 1 subunit alpha E. caballus 99.0 2009
XP_002712295.1 PREDICTED: sodium channel, voltage-gated, type I, alpha subunit isoform 1 O. cuniculus 99.0 2008

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: normal [show more like this]
infant [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; muscle; mixed; eye
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 2
Map position: 2q24.3
UniSTS entry: Chr 2 HSC2FB112 [Map Viewer]
UniSTS entry: Chr 2 A006O14
UniSTS entry: Chr 2 SCN1A_3451
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (17)

AY043484.1 Homo sapiens voltage-gated sodium channel type I mRNA, complete cds PA
AK094487.1 Homo sapiens cDNA FLJ37168 fis, clone BRACE2027767
NM_006920.4 Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 2, mRNA P
AK293759.1 Homo sapiens cDNA FLJ58789 complete cds, highly similar to Sodium channel protein type 1 subunit alpha P
AK294900.1 Homo sapiens cDNA FLJ56968 complete cds, highly similar to Sodium channel protein type 1 subunit alpha P
X65362.1 Homo sapiens mRNA for brain type I sodium channel alpha-subunit (SCN1A) P
NM_001165964.1 Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 3, mRNA PA
NM_001165963.1 Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 1, mRNA PA
M91803.1 Human sodium channel mRNA P
NM_001202435.1 Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 4, mRNA PA
HQ726799.1 Homo sapiens isolate usm_gefs0310 sodium channel voltage gated type 1 alpha subunit transcript variant 2 (SCN1A) mRNA, partial cds
HQ726798.1 Homo sapiens isolate usm_gefs0210 sodium channel voltage gated type 1 alpha subunit transcript variant 2 (SCN1A) mRNA, exons 8, 9 and partial cds
HQ726796.1 Homo sapiens isolate usm_gefs0209 sodium channel voltage gated type 1 alpha subunit transcript variant 2 (SCN1A) mRNA, exon 26 and partial cds
HQ726795.1 Homo sapiens isolate usm_gefs0109 sodium channel voltage gated type 1 alpha subunit transcript variant 2 (SCN1A) mRNA, exon 25 and partial cds
AB093549.1 Homo sapiens SCN1A mRNA for Voltage-gated sodium channel alpha1 subunit, complete cds, isoform type P
AB093548.1 Homo sapiens SCN1A mRNA for voltage-gated sodium channel alpha1 subunit, complete cds P
AB098335.1 Homo sapiens SCN1A mRNA for Voltage-gated sodium channel alpha 1 subunit, complete cds P

EST sequences (10 of 49) [Show all sequences]

BX116162.1 Clone IMAGp998M08161_;_IMAGE:35683 brain A
R45971.1 Clone IMAGE:35683 brain 3' read A
R44514.1 Clone IMAGE:33245 brain 3' read A
R61121.1 Clone IMAGE:42653 brain 5' read
R61843.1 Clone IMAGE:42653 brain 3' read A
BX432053.2 Clone CS0DN004YF22 brain 5' read
BX477644.1 Clone DKFZp686B19198 muscle 5' read
BX507999.1 Clone DKFZp686B19263 muscle 5' read P
F07703.1 Clone c-2fb11 brain
F03961.1 Clone c-2fb11 brain 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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