HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1)

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UGID:164055 UniGene Hs.210385 Homo sapiens (human) HERC1

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HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1)

Human protein-coding gene HERC1. Represented by 381 ESTs from 205 cDNA libraries. Corresponds to reference sequence NM_003922.3. [UniGene 164055 - Hs.210385]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_003913.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	HERC1 gene product	H. sapiens	100.0	4860
XP_001174017.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: probable E3 ubiquitin-protein ligase HERC1 isoform 1	P. troglodytes	99.9	4860
XP_003901090.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: probable E3 ubiquitin-protein ligase HERC1-like	P. anubis	99.8	3313
NP_663592.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	hect domain and RCC1-like domain 1	M. musculus	98.4	4858
XP_698091.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: hect domain and RCC1-like domain 1-like	D. rerio	86.8	4845
NP_608388.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	HERC2	D. melanogaster	47.1	1820
Other hits (2 of 32) [Show all]		Species	Id(%)	Len(aa)
XP_002804832.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: probable E3 ubiquitin-protein ligase HERC1-like	M. mulatta	99.4	4823
NP_001096752.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	HERC1 gene product	B. taurus	99.0	512

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; testis; mammary gland; uterus; bladder; amniotic fluid; spleen; prostate; thymus; intestine; bone marrow; placenta; thyroid; spinal cord; lung; mixed; heart; connective tissue; lymph node; mouth; pharynx; muscle; pancreas; eye; uncharacterized tissue; liver; embryonic tissue; ear; kidney; trachea; epididymis; blood; ovary; ascites; nerve; ganglia; cervix; bone; adipose tissue; parathyroid; larynx

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	15
Map position:	15q22
UniSTS entry:	Chr 15	STS-H16734	[Map Viewer]
UniSTS entry:	Chr 15	STS-U50078
UniSTS entry:	Chr 15	WI-20175	[Map Viewer]
UniSTS entry:	Chr 15	D15S620E
UniSTS entry:		G19869
UniSTS entry:		A002A45
UniSTS entry:	Chr 15	SHGC-30742	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

NM_003922.3	Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), mRNA	PA
AK226162.1	Homo sapiens mRNA for guanine nucleotide exchange factor p532 variant, clone: ff11573	P
U50078.1	Human guanine nucleotide exchange factor p532 mRNA, complete cds	PA
AK310519.1	Homo sapiens cDNA, FLJ17561	P
AK296690.1	Homo sapiens cDNA FLJ60284 complete cds, highly similar to Homo sapiens guanine nucleotide exchange factor p532	P
BC040929.1	Homo sapiens hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1, mRNA (cDNA clone IMAGE:4472317), partial cds	PA

EST sequences (10 of 381) [Show all sequences]

R14326.1	Clone IMAGE:28896	brain	5' read	P
AI002937.1	Clone IMAGE:1698765	kidney	3' read	A
AI033151.1	Clone IMAGE:1654443	mixed	3' read
AI049746.1	Clone IMAGE:1699814	kidney	3' read	A
R20007.1	Clone IMAGE:33951	brain	5' read
AI057309.1	Clone IMAGE:1673036	mixed	3' read
BX109034.1	Clone IMAGp998D07145_;_IMAGE:28896	brain		PA
R25475.1	Clone IMAGE:132339	placenta	5' read
CB163553.1	Clone L17N670205n1-32-F06	liver	5' read
R39085.1	Clone IMAGE:25038	brain	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria