> Survival of motor neuron 2, centromeric (SMN2)
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UGID:162646     UniGene Hs.202179     Homo sapiens (human)   SMN2 Order cDNA clone, Links
Survival of motor neuron 2, centromeric (SMN2)

Human protein-coding gene SMN2. Represented by 301 ESTs from 158 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 162646 - Hs.202179]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001156488.1 PREDICTED: survival motor neuron protein isoform 7 P. troglodytes 100.0 296
NP_059107.1 SMN2 gene product H. sapiens 100.0 293
NP_035550.1 Smn1 gene product M. musculus 87.8 287
NP_001082386.1 survival of motor neuron 2, centromeric X. laevis 61.9 268
NP_571266.1 smn1 gene product D. rerio 59.3 270
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_001096348.2 PREDICTED: survival motor neuron protein isoform 1 M. mulatta 98.6 293
XP_003919619.1 PREDICTED: LOW QUALITY PROTEIN: survival motor neuron protein P. anubis 97.0 298

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; cervix; liver; blood; placenta; intestine; prostate; mammary gland; vascular; uncharacterized tissue; muscle; kidney; stomach; skin; lung; mixed; pituitary gland; testis; amniotic fluid; uterus; eye; pancreas; heart; bone; pharynx; mouth; thyroid; lymph node; ear; ovary; adrenal gland; thymus; bladder; larynx; tonsil; salivary gland; connective tissue; ascites; nerve; ganglia
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5q13.2
UniSTS entry: Chr 5 D5S1946
UniSTS entry: Chr 5 SMN1
UniSTS entry: Chr 5 G20836
UniSTS entry: Chr 5 A006I11
UniSTS entry: Chr 5 D5S2463 [Map Viewer]
UniSTS entry: Chr 5 STS-U18423
UniSTS entry: Chr 5 D5S2798
UniSTS entry: Chr 5 D5S2797
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

BC070242.1 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:88227 IMAGE:4673318), complete cds PA
DQ185039.1 Homo sapiens survival of motor neuron 2 variant 1 (SMN2) mRNA, 3' UTR
NM_017411.3 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant d, mRNA PA
BC000908.2 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:5208 IMAGE:2985046), complete cds PA
NM_022875.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant a, mRNA PA
NM_022876.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant b, mRNA PA
NM_022877.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant c, mRNA PA
U21914.1 Homo sapiens putative open reading frame; duplicate of the functional spinal muscular atrophy gene, cDNA clone BCD514, GenBank Accession Number U18423; it is not known if this copy of the gene is actually translated mRNA, partial cds PA
BC015308.1 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:20996 IMAGE:4427000), complete cds PA
AK289669.1 Homo sapiens cDNA FLJ76644 complete cds, highly similar to Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant a, mRNA P
JQ690866.1 Homo sapiens survival motor neuron protein isoform g (SMN2) mRNA, exons 2b, 4, 6 through 8 and partial cds, alternatively spliced P
JQ690864.1 Homo sapiens survival motor neuron protein isoform j (SMN2) mRNA, exons 2b, 3, 5, 6, 8 and partial cds, alternatively spliced P
JQ690862.1 Homo sapiens survival motor neuron protein isoform h (SMN2) mRNA, exons 2b, 4 through 6, 8 and partial cds, alternatively spliced P
JQ690865.1 Homo sapiens survival motor neuron protein isoform c (SMN2) mRNA, exons 2b through 4, 6, 8 and partial cds, alternatively spliced P
JQ690863.1 Homo sapiens survival motor neuron protein isoform i (SMN2) mRNA, exons 2b, 4, 6, 8 and partial cds, alternatively spliced P
JQ690861.1 Homo sapiens survival motor neuron protein isoform e (SMN2) mRNA, exons 2b, 4 through 8 and partial cds, alternatively spliced P

EST sequences (10 of 301) [Show all sequences]

AA954966.1 Clone IMAGE:1577759 mixed 3' read A
AA988429.1 Clone IMAGE:1601880 lung 3' read A
AA989486.1 Clone IMAGE:1606262 kidney 3' read A
AA927924.1 Clone IMAGE:1541852 mixed 3' read
AI075751.1 Clone IMAGE:1676884 embryonic tissue 3' read A
CB051613.1 Clone IMAGE:3289914 uncharacterized tissue 3' read A
R33396.1 Clone IMAGE:136170 placenta 5' read P
R33397.1 Clone IMAGE:136170 placenta 3' read A
AI224909.1 Clone IMAGE:1858070 mixed 3' read A
AI247115.1 Clone IMAGE:2004991 pancreas 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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