> MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
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UGID:161374     UniGene Hs.195364     Homo sapiens (human)   MLH1 Order cDNA clone, Links
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)

Human protein-coding gene MLH1. Represented by 575 ESTs from 253 cDNA libraries. Corresponds to 7 reference sequences (different isoforms). [UniGene 161374 - Hs.195364]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001170433.1 PREDICTED: DNA mismatch repair protein Mlh1 isoform 8 P. troglodytes 100.0 755
NP_000240.1 MLH1 gene product H. sapiens 100.0 755
NP_081086.2 Mlh1 gene product M. musculus 95.5 759
NP_001090545.1 mutL homolog 1, colon cancer, nonpolyposis type 2 X. laevis 86.4 749
NP_956953.1 mlh1 gene product D. rerio 81.6 723
XP_962522.1 hypothetical protein NCU08309 N. crassa 62.9 429
NP_499796.2 Protein MLH-1 C. elegans 61.0 241
NP_567345.2 DNA mismatch repair protein MLH1 A. thaliana 60.5 342
XP_001690102.1 mismatch repair protein C. reinhardtii 60.2 417
NP_013890.1 mismatch repair ATPase MLH1 S. cerevisiae 60.2 339
NP_477022.1 Mlh1, isoform A D. melanogaster 59.1 661
Other hits (2 of 60) [Show all]SpeciesId(%)Len(aa)
XP_001087274.1 PREDICTED: DNA mismatch repair protein Mlh1-like M. mulatta 99.5 578
XP_003894736.1 PREDICTED: DNA mismatch repair protein Mlh1 isoform 1 P. anubis 99.5 755

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; connective tissue; kidney; cervix; mouth; placenta; skin; eye; lymph; umbilical cord; adrenal gland; uncharacterized tissue; uterus; blood; intestine; spleen; mixed; ovary; heart; lung; prostate; muscle; pituitary gland; embryonic tissue; liver; esophagus; pancreas; mammary gland; vascular; thymus; thyroid; salivary gland; ascites; bone; stomach; lymph node; bladder; tonsil; pharynx; trachea; nerve; adipose tissue; bone marrow; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 3
Map position: 3p21.3
UniSTS entry: Chr 3 SHGC-12575 [Map Viewer]
UniSTS entry: GDB:549088
UniSTS entry: Chr 3 PMC140684P8
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (41)

BX648844.1 Homo sapiens mRNA; cDNA DKFZp686I14153 (from clone DKFZp686I14153) PA
NM_000249.3 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 1, mRNA PA
AY517558.1 Homo sapiens hypothetical rhabdomyosarcoma antigen MU-RMS-40.5 mRNA, partial cds P
AB209848.1 Homo sapiens mRNA for MutL protein homolog 1 variant protein P
AK222810.1 Homo sapiens mRNA for MutL protein homolog 1 variant, clone: HEP04585 PA
DQ648893.1 Homo sapiens MLH1-Ex(14-18) isoform (MLH1) mRNA, partial cds, alternatively spliced
DQ648892.1 Homo sapiens MLH1-Ex(15-18) isoform (MLH1) mRNA, partial cds, alternatively spliced P
DQ648891.1 Homo sapiens MLH1-Ex(9-10) isoform (MLH1) mRNA, partial cds, alternatively spliced P
DQ648890.1 Homo sapiens MLH1-Ex10 isoform (MLH1) mRNA, partial cds, alternatively spliced
DQ648889.1 Homo sapiens MLH1-Ex6 isoform (MLH1) mRNA, partial cds, alternatively spliced
DQ648888.1 Homo sapiens MLH1+ins1a isoform (MLH1) mRNA, complete cds, alternatively spliced
BC006850.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), mRNA (cDNA clone MGC:5172 IMAGE:3451538), complete cds PA
U07418.1 Human DNA mismatch repair (hmlh1) mRNA, complete cds P
U07343.1 Homo sapiens DNA mismatch repair protein homolog (MLH1) mRNA, complete cds P
EU188676.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188675.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188674.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188673.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188672.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188671.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188670.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188669.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188668.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188667.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188666.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
EU188665.1 Homo sapiens MutL-like 1 protein (MLH1) mRNA, partial cds, alternatively spliced P
AK311365.1 Homo sapiens cDNA, FLJ18407 P
AK311326.1 Homo sapiens cDNA, FLJ18368 P
AK312609.1 Homo sapiens cDNA, FLJ92988, highly similar to Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), mRNA P
AK298583.1 Homo sapiens cDNA FLJ50608 complete cds, highly similar to DNA mismatch repair protein Mlh1 PA
AK298324.1 Homo sapiens cDNA FLJ50603 complete cds, highly similar to DNA mismatch repair protein Mlh1 P
AK295359.1 Homo sapiens cDNA FLJ50524 complete cds, highly similar to DNA mismatch repair protein Mlh1 P
AK316264.1 Homo sapiens cDNA, FLJ79163 complete cds, highly similar to DNA mismatch repair protein Mlh1 P
AK316074.1 Homo sapiens cDNA, FLJ78973 complete cds, highly similar to DNA mismatch repair protein Mlh1 P
AK302807.1 Homo sapiens cDNA FLJ55289 complete cds, highly similar to DNA mismatch repair protein Mlh1 P
NM_001167619.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 4, mRNA PA
NM_001167618.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 3, mRNA PA
NM_001167617.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 2, mRNA PA
NM_001258273.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 6, mRNA PA
NM_001258274.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 7, mRNA PA
NM_001258271.1 Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 5, mRNA PA

EST sequences (10 of 575) [Show all sequences]

AA994433.1 Clone IMAGE:1631905 mammary gland 3' read
AI005201.1 Clone IMAGE:1632208 mammary gland 3' read PA
AI024414.1 Clone IMAGE:1641680 testis 3' read PA
AI041208.1 Clone IMAGE:1643396 testis 3' read PA
AI049637.1 Clone IMAGE:1700298 kidney 3' read PA
AI082636.1 Clone IMAGE:1669872 brain 3' read PA
AI125538.1 Clone IMAGE:1737107 testis 3' read A
BX098613.1 Clone IMAGp998B18587_;_IMAGE:267569 skin P
AI189553.1 Clone IMAGE:1725012 placenta 3' read PA
AI266630.1 Clone IMAGE:1891657 placenta 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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