Cereblon (CRBN)

NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs

UGID:133887 UniGene Hs.18925 Homo sapiens (human) CRBN

Order cDNA clone, Links

Cereblon (CRBN)

Human protein-coding gene CRBN. Represented by 579 ESTs from 263 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 133887 - Hs.18925]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001182576.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cereblon	M. mulatta	100.0	441
XP_003894216.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: protein cereblon	P. anubis	100.0	441
XP_001140433.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: protein cereblon isoform 3	P. troglodytes	100.0	441
NP_057386.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	CRBN gene product	H. sapiens	100.0	441
NP_780566.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Crbn gene product	M. musculus	96.8	444
NP_001003996.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	crbn gene product	D. rerio	79.6	430
Other hits (2 of 25) [Show all]		Species	Id(%)	Len(aa)
XP_533757.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: protein cereblon isoform 1	C. lupus familiaris	98.9	443
XP_001496748.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: protein cereblon	E. caballus	98.6	441

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; testis; uterus; skin; mammary gland; embryonic tissue; heart; thyroid; placenta; pharynx; uncharacterized tissue; kidney; lung; mixed; adrenal gland; cervix; prostate; lymph node; ear; blood; liver; intestine; muscle; bone marrow; parathyroid; thymus; eye; trachea; connective tissue; bladder; vascular; pituitary gland; mouth; pancreas; spleen; esophagus; stomach; nerve; bone; ascites; salivary gland; ovary; adipose tissue

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	3
Map position:	3p26.2
UniSTS entry:	Chr 3	SHGC-34652	[Map Viewer]
UniSTS entry:	Chr 3	WI-20982	[Map Viewer]
UniSTS entry:	Chr 3	SHGC-76662	[Map Viewer]
UniSTS entry:	Chr 3	RH102607

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BC059171.1	Homo sapiens cDNA clone IMAGE:3829233, containing frame-shift errors	PA
BC067811.1	Homo sapiens cereblon, mRNA (cDNA clone MGC:87290 IMAGE:5264951), complete cds	PA
CR627060.1	Homo sapiens mRNA; cDNA DKFZp781K0715 (from clone DKFZp781K0715)	PA
AF117230.1	Homo sapiens protein x 0001 mRNA, complete cds	PA
NM_016302.3	Homo sapiens cereblon (CRBN), transcript variant 1, mRNA	P
AK027507.1	Homo sapiens cDNA FLJ14601 fis, clone NT2RP1000124	P
BC017419.1	Homo sapiens cereblon, mRNA (cDNA clone MGC:27358 IMAGE:4672890), complete cds	PA
AK058191.1	Homo sapiens cDNA FLJ25462 fis, clone TST09217, highly similar to Mus musculus piL mRNA	P
AK312577.1	Homo sapiens cDNA, FLJ92952, highly similar to Homo sapiens protein x 0001 (LOC51185), mRNA	P
AK301423.1	Homo sapiens cDNA FLJ52785 complete cds, highly similar to Protein cereblon	P
NM_001173482.1	Homo sapiens cereblon (CRBN), transcript variant 2, mRNA	P

EST sequences (10 of 579) [Show all sequences]

AA991754.1	Clone IMAGE:1623836	embryonic tissue	3' read
AI015656.1	Clone IMAGE:1635552	kidney	3' read
AI038380.1	Clone IMAGE:1656991	mixed	3' read
AI042615.1	Clone IMAGE:1668138	parathyroid	3' read
AI138966.1	Clone IMAGE:1735690	testis	3' read
AI140921.1	Clone IMAGE:1690807	mixed	3' read
AI146587.1	Clone IMAGE:1704240	brain	3' read
BX105410.1	Clone IMAGp998C08224_;_IMAGE:147391	placenta		P
AI167819.1	Clone IMAGE:1682622	parathyroid	3' read
AI190972.1	Clone IMAGE:1739208	lung	3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria