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UGID:131101     UniGene Hs.1867     Homo sapiens (human)   PGC
Progastricsin (pepsinogen C) (PGC)

Human protein-coding gene PGC. Represented by 378 ESTs from 58 cDNA libraries. EST representation biased toward gastrointestinal tumor; adult. Corresponds to 2 reference sequences (different isoforms). [UniGene 131101 - Hs.1867]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_002621.1 PGC gene product H. sapiens 100.0 387
NP_080249.2 gastricsin precursor M. musculus 83.0 389
NP_001079036.1 gastricsin precursor X. laevis 73.1 382
NP_609235.1 beta-site APP-cleaving enzyme D. melanogaster 53.0 279
XP_959917.1 vacuolar protease A precursor N. crassa 49.5 208
NP_172655.1 aspartic proteinase A1 A. thaliana 49.2 250
XP_001692331.1 pepsin-type aspartyl protease C. reinhardtii 48.0 221
NP_571785.1 ctsd gene product D. rerio 47.5 282
NP_510191.1 Protein ASP-4 C. elegans 45.0 171
Other hits (2 of 58) [Show all]SpeciesId(%)Len(aa)
XP_518465.2 PREDICTED: gastricsin isoform 2 P. troglodytes 99.2 387
NP_001162218.1 gastricsin precursor P. anubis 98.2 387

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: gastrointestinal tumor [show more like this]
adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: stomach; ascites; lung; mixed; prostate; uncharacterized tissue; pancreas; esophagus; brain; connective tissue; liver; heart
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.1
UniSTS entry: Chr 6 SHGC-35331 [Map Viewer]
UniSTS entry: Chr 6 RH46782 [Map Viewer]
UniSTS entry: Chr 6 PGC
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

BC042578.1 Homo sapiens progastricsin (pepsinogen C), mRNA (cDNA clone IMAGE:5180836), complete cds PA
NM_002630.3 Homo sapiens progastricsin (pepsinogen C) (PGC), transcript variant 1, mRNA PA
BC073740.1 Homo sapiens progastricsin (pepsinogen C), mRNA (cDNA clone MGC:88742 IMAGE:6296399), complete cds PA
AK223274.1 Homo sapiens mRNA, progastricsin variant, clone: STM08043 PA
J04443.1 Homo sapiens pepsinogen C (PGC) mRNA, complete cds P
AK301325.1 Homo sapiens cDNA FLJ51342 complete cds, highly similar to Gastricsin precursor (EC 3.4.23.3) PA
AK301298.1 Homo sapiens cDNA FLJ58861 complete cds, highly similar to Gastricsin precursor (EC 3.4.23.3) P
NM_001166424.1 Homo sapiens progastricsin (pepsinogen C) (PGC), transcript variant 2, mRNA P
U75272.1 Human gastricsin mRNA, complete cds PA

EST sequences (10 of 378) [Show all sequences]

AA906670.1 Clone IMAGE:1522288 lung 3' read PA
CB049755.1 Clone IMAGE:3271557 prostate 3' read PA
BX115434.1 Clone IMAGp998I176105_;_IMAGE:2455000 pancreas PA
AI270354.1 Clone IMAGE:1978999 stomach 3' read PA
AI270510.1 Clone IMAGE:1978866 stomach 3' read A
AI225042.1 Clone IMAGE:1998886 stomach 3' read PA
AI286304.1 Clone IMAGE:1979471 stomach 3' read PA
AI418102.1 Clone IMAGE:2095723 prostate 3' read A
AI445482.1 Clone IMAGE:2142417 stomach 3' read A
AI445740.1 Clone IMAGE:2141005 stomach 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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