Afamin (AFM)

Restricted Expression:

liver tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

kidney; liver; uncharacterized tissue; mixed; mammary gland; heart

NCBI

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Finding cDNAs

UGID:157320 UniGene Hs.168718 Homo sapiens (human) AFM

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Afamin (AFM)

Human protein-coding gene AFM. Represented by 66 ESTs from 20 cDNA libraries. EST representation biased toward liver tumor. Corresponds to reference sequence NM_001133.2. [UniGene 157320 - Hs.168718]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001124.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	AFM gene product	H. sapiens	100.0	598
NP_660128.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Afm gene product	M. musculus	72.9	605
Other hits (2 of 12) [Show all]		Species	Id(%)	Len(aa)
XP_517229.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: afamin	P. troglodytes	99.3	598
XP_003898831.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: afamin	P. anubis	93.8	483

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	4
Map position:	4q13.3
UniSTS entry:	Chr 4	STS-L32140
UniSTS entry:	Chr 4	RH94242

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (5)

NM_001133.2	Homo sapiens afamin (AFM), mRNA	P
BC109020.1	Homo sapiens afamin, mRNA (cDNA clone MGC:125338 IMAGE:40006696), complete cds	P
BC109021.1	Homo sapiens afamin, mRNA (cDNA clone MGC:125339 IMAGE:40006697), complete cds	P
AK290556.1	Homo sapiens cDNA FLJ76019 complete cds, highly similar to Homo sapiens afamin (AFM), mRNA	P
L35498.1	Homo sapiens alpha-albumin mRNA, segment 3 of 3, segmented cds.

EST sequences (10 of 66) [Show all sequences]

BX110719.1	Clone IMAGp998H135336_;_IMAGE:2160828	kidney		P
BX103962.1	Clone IMAGp998C061074_;_IMAGE:454589	mixed
CB157386.1	Clone L17N670205n1-3-H09	liver	5' read	P
CB162042.1	Clone L17N670205n1-16-E06	liver	5' read	P
AI247575.1	Clone IMAGE:1849085	mixed	3' read	A
AI492289.1	Clone IMAGE:2131234	kidney	3' read	P
AI580400.1	Clone IMAGE:2160828	kidney	3' read	A
AI670871.1	Clone IMAGE:2297286	kidney	3' read	A
AI670879.1	Clone IMAGE:2297285	kidney	3' read	A
AI671722.1	Clone IMAGE:2297181	kidney	3' read	PA

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria