Low density lipoprotein receptor-related protein 1 (LRP1)

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UGID:156459 UniGene Hs.162757 Homo sapiens (human) LRP1

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Low density lipoprotein receptor-related protein 1 (LRP1)

Human protein-coding gene LRP1. Represented by 1029 ESTs from 352 cDNA libraries. Corresponds to reference sequence NM_002332.2. [UniGene 156459 - Hs.162757]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_002323.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	LRP1 gene product	H. sapiens	100.0	4543
XP_003126347.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: prolow-density lipoprotein receptor-related protein 1-like	S. scrofa	99.5	1589
NP_032538.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Lrp1 gene product	M. musculus	98.8	4544
XP_001920591.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: low-density lipoprotein receptor-related protein 1	D. rerio	81.8	4534
NP_001079233.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	low density lipoprotein receptor-related protein 6 precursor	X. laevis	51.8	540
NP_001096924.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	megalin, isoform A	D. melanogaster	49.9	3096
NP_492127.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein LRP-1	C. elegans	49.5	3148
Other hits (2 of 37) [Show all]		Species	Id(%)	Len(aa)
XP_538245.4 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: prolow-density lipoprotein receptor-related protein 1	C. lupus familiaris	99.1	4543
XP_003582266.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1	B. taurus	99.0	4543

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	brain; uncharacterized tissue; placenta; embryonic tissue; lung; connective tissue; muscle; pancreas; eye; uterus; testis; bone; intestine; mammary gland; prostate; mixed; ovary; kidney; heart; mouth; skin; blood; nerve; liver; trachea; spleen; stomach; adipose tissue; thymus; larynx; pharynx; pituitary gland; cervix; vascular; ganglia; epididymis; spinal cord; thyroid; salivary gland

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	12
Map position:	12q13.3
UniSTS entry:	Chr 12	RH44498	[Map Viewer]
UniSTS entry:	Chr 12	G28611
UniSTS entry:	Chr 11	RH64899
UniSTS entry:	Chr 12	RH45009	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

BC045107.1	Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), mRNA (cDNA clone IMAGE:4859182), complete cds	PA
BC052593.1	Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), mRNA (cDNA clone IMAGE:6575284), complete cds	PA
NM_002332.2	Homo sapiens low density lipoprotein receptor-related protein 1 (LRP1), mRNA	PA
BC072015.1	Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), mRNA (cDNA clone IMAGE:6384902), complete cds	PA
AB209498.1	Homo sapiens mRNA for low density lipoprotein-related protein 1 variant protein	P
EF491814.1	Homo sapiens clone LRP1 mRNA, partial sequence; alternatively spliced
EF491795.1	Homo sapiens clone LRP1 mRNA, partial sequence; alternatively spliced
X13916.1	Human mRNA for LDL-receptor related protein	PA
BC021204.2	Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), mRNA (cDNA clone IMAGE:4110815), complete cds	PA
X55077.1	H.sapiens mRNA fragment for alpha-2 macroglobulin receptor	P

EST sequences (10 of 1029) [Show all sequences]

AA903682.1	Clone IMAGE:1517729	uncharacterized tissue	3' read	A
AA968513.1	Clone IMAGE:1575002	kidney	3' read	A
AA970647.1	Clone IMAGE:1574518	kidney	3' read
R14915.1	Clone IMAGE:30219	brain	5' read
AA902301.1	Clone IMAGE:1519742	uncharacterized tissue	3' read
AI004371.1	Clone IMAGE:1624529	embryonic tissue	3' read
AI022443.1	Clone IMAGE:1654708	mixed	3' read
AI027631.1	Clone IMAGE:1645459	testis	3' read
AI040093.1	Clone IMAGE:1659937	embryonic tissue	3' read
T27079.1	Clone LLAB258B01	brain	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria