Claudin 8 (CLDN8)

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UGID:156257 UniGene Hs.162209 Homo sapiens (human) CLDN8

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Claudin 8 (CLDN8)

Human protein-coding gene CLDN8. Represented by 57 ESTs from 29 cDNA libraries. Corresponds to reference sequence NM_199328.2. [UniGene 156257 - Hs.162209]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_531532.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: claudin-8	P. troglodytes	100.0	224
NP_955360.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	claudin-8	H. sapiens	100.0	224
XP_001100214.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: claudin-8-like	M. mulatta	99.6	224
NP_061248.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Cldn8 gene product	M. musculus	84.9	224
NP_001087400.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	claudin 3	X. laevis	56.6	203
NP_571840.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cldne gene product	D. rerio	51.0	208
Other hits (2 of 21) [Show all]		Species	Id(%)	Len(aa)
XP_003895606.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: claudin-8	P. anubis	98.2	224
XP_001499364.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: claudin-8-like	E. caballus	88.4	224

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	kidney; prostate; intestine; thyroid; mammary gland; lung; mixed; esophagus; skin; testis; embryonic tissue

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

	Chromosome:	21
	Map position:	21q22.11

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (6)

AL049977.1	Homo sapiens mRNA; cDNA DKFZp564C122 (from clone DKFZp564C122)	A
BC058004.1	Homo sapiens claudin 8, mRNA (cDNA clone MGC:61830 IMAGE:4606880), complete cds	PA
AY358707.1	Homo sapiens clone DNA73735 CLDN8 (UNQ779) mRNA, complete cds	P
NM_199328.2	Homo sapiens claudin 8 (CLDN8), mRNA	P
AK223512.1	Homo sapiens mRNA for claudin 8 variant, clone: FCC122A06	P
AK022269.1	Homo sapiens cDNA FLJ12207 fis, clone MAMMA1000956, highly similar to Claudin-8	P

EST sequences (10 of 57) [Show all sequences]

AI547146.1		prostate	5' read
CB306981.1	Clone UI-CF-FN0-aen-j-20-0-UI	lung	3' read	A
BX283446.1	Clone IMAGp958G091346_;_IMAGE:4606880	kidney		P
CB851106.1	Clone UI-CF-EN1-adg-i-18-0-UI	lung	3' read	A
CB851224.1	Clone UI-CF-DU1-adn-j-21-0-UI	lung	3' read
CF140477.1	Clone IMAGE:3098017	prostate	5' read
CF140548.1	Clone IMAGE:3098017	prostate	5' read	P
AW205135.1	Clone IMAGE:2720040	mixed	3' read	A
AW235670.1	Clone IMAGE:2694358	kidney	3' read	A
AW237740.1	Clone IMAGE:2690572	kidney	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria