> Bruton agammaglobulinemia tyrosine kinase (BTK)
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UGID:155663     UniGene Hs.159494     Homo sapiens (human)   BTK Order cDNA clone, Links
Bruton agammaglobulinemia tyrosine kinase (BTK)

Human protein-coding gene BTK. Represented by 147 ESTs from 72 cDNA libraries. EST representation biased toward neonate. Corresponds to reference sequence NM_000061.2. [UniGene 155663 - Hs.159494]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001139132.2 PREDICTED: tyrosine-protein kinase BTK isoform 6 P. troglodytes 100.0 692
NP_000052.1 BTK gene product H. sapiens 100.0 658
XP_002806376.1 PREDICTED: tyrosine-protein kinase BTK-like M. mulatta 99.8 638
XP_003918046.1 PREDICTED: tyrosine-protein kinase BTK P. anubis 99.8 633
XP_001493268.1 PREDICTED: tyrosine-protein kinase BTK E. caballus 99.7 658
XP_002720413.1 PREDICTED: Bruton agammaglobulinemia tyrosine kinase O. cuniculus 99.7 658
XP_549139.2 PREDICTED: tyrosine-protein kinase BTK isoform 1 C. lupus familiaris 99.5 658
XP_003135290.2 PREDICTED: tyrosine-protein kinase BTK-like S. scrofa 99.5 658
NP_001029761.1 BTK gene product B. taurus 99.5 658
NP_038510.2 Btk gene product M. musculus 99.2 658
XP_697087.4 PREDICTED: tyrosine-protein kinase BTK D. rerio 72.1 634
NP_001089927.1 uncharacterized protein LOC734996 X. laevis 64.7 623
NP_001097120.1 Btk family kinase at 29A, isoform F D. melanogaster 59.3 450
NP_001021778.1 Protein CSK-1 C. elegans 48.1 162
Other hits (2 of 31) [Show all]SpeciesId(%)Len(aa)
NP_001007799.1 Btk gene product R. norvegicus 99.1 659
XP_004022535.1 PREDICTED: tyrosine-protein kinase BTK O. aries 99.1 657

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: blood; spleen; pancreas; liver; intestine; mixed; mammary gland; tonsil; lymph; brain; uncharacterized tissue; lymph node; stomach; bone marrow; connective tissue; pharynx; thyroid; skin; lung; thymus; trachea; uterus; testis; esophagus; heart; prostate; muscle; bone
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: X
Map position: Xq21.33-q22
UniSTS entry: Btk
UniSTS entry: Chr X RH93533
UniSTS entry: Chr X RH35738
UniSTS entry: Chr X G44349
UniSTS entry: Chr X GDB:376892
UniSTS entry: GDB:555569
UniSTS entry: Chr X RH80171
UniSTS entry: Chr X BTK_4321
UniSTS entry: GDB:555566
UniSTS entry: Chr 1 D1S1425
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (37)

NM_000061.2 Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA PA
AF153756.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153757.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153758.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153759.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153760.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153761.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153762.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AF153763.1 Homo sapiens Bruton's tyrosine kinase mRNA, partial cds P
AF153764.1 Homo sapiens Bruton's tyrosine kinase mRNA, partial cds P
AF153364.1 Homo sapiens Bruton's tyrosine kinase mRNA, complete cds P
AJ888381.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 14) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AJ888380.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 15 to 18) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia P
AJ888379.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 13 to 17) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AJ888378.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 52 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia P
AJ888377.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 51 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AJ888376.1 Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 65 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia P
AM051286.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 12 (BTK kinase deficient isoform 12 gene), cell type E2A-PBX1+ leukemia cells
AM051285.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11 (BTK kinase deficient isoform 11 gene), cell type E2A-PBX1+ leukemia cells P
AM051284.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10 (BTK kinase deficient isoform 10 gene), cell type TEL-AML1+ leukemia cells P
AM051283.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9 (BTK kinase deficient isoform 9 gene), cell type TEL-AML1+ leukemia cells
AM051282.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 8 (BTK kinase deficient isoform 8 gene), cell type TEL-AML1+ leukemia cells P
AM051281.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 7 (BTK kinase deficient isoform 7 gene), cell type TEL-AML1+ leukemia cells
AM051280.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6 (BTK kinase deficient isoform 6 gene), cell type BCR-ABL1+ leukemia cells P
AM051279.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5 (BTK kinase deficient isoform 5 gene), cell type BCR-ABL1+ leukemia cells P
AM051278.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4 (BTK kinase deficient isoform 4 gene), cell type BCR-ABL1+ leukemia cells P
AM051277.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3 (BTK kinase deficient isoform 3 gene), cell type MLL-AF4+ leukemia cells P
AM051276.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2 (BTK kinase deficient isoform 2 gene), cell type MLL-AF4+ leukemia cells P
AM051275.1 Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 1 (BTK kinase deficient isoform 1 gene), cell type BCR-ABL1+ and MLL-AF4+ leukemia cells P
BC109080.1 Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126262 IMAGE:40034289), complete cds P
BC109079.1 Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126261 IMAGE:40034287), complete cds P
AK225577.1 Homo sapiens mRNA for Bruton agammaglobulinemia tyrosine kinase variant, clone: LNG09949 PA
AK057105.1 Homo sapiens cDNA FLJ32543 fis, clone SMINT2000538, highly similar to Tyrosine-protein kinase BTK (EC 2.7.10.2) P
AK314382.1 Homo sapiens cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA P
AK309851.1 Homo sapiens cDNA, FLJ99892 P
AF153755.1 Homo sapiens Bruton's tyrosine kinase mRNA, partial cds P
X58957.1 H.sapiens atk mRNA for agammaglobulinaemia tyrosine kinase PA

EST sequences (10 of 147) [Show all sequences]

AA911703.1 Clone IMAGE:1521055 lung 3' read A
BX097544.1 Clone IMAGp998B09659_;_IMAGE:295208 mixed
AI361486.1 Clone IMAGE:2015215 brain 3' read A
AI362055.1 Clone IMAGE:2014424 brain 3' read A
AI571957.1 Clone IMAGE:2223789 pancreas 3' read A
AI768960.1 Clone IMAGE:2364069 mixed 3' read A
BX325261.2 Clone CS0DL002YE22 uncharacterized tissue 3' read P
BX325262.2 Clone CS0DL002YE22 uncharacterized tissue 5' read P
CD365313.1 Clone UI-H-FT2-bjj-c-14-0-UI lung 3' read PA
CD687911.1 pharynx P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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