> Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4)
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UGID:131032     UniGene Hs.1565     Homo sapiens (human)   NEDD4 Order cDNA clone, Links
Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4)

Human protein-coding gene NEDD4. Represented by 204 ESTs from 98 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 131032 - Hs.1565]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_940682.2 NEDD4 gene product H. sapiens 100.0 1246
XP_523083.3 PREDICTED: e3 ubiquitin-protein ligase NEDD4 isoform 5 P. troglodytes 99.8 899
NP_035020.2 Nedd4 gene product M. musculus 94.0 886
NP_001029358.1 nedd4a gene product D. rerio 79.2 907
NP_001084258.1 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase X. laevis 74.6 968
NP_490865.3 Protein Y92H12A.2 C. elegans 63.6 562
NP_730283.1 Nedd4, isoform F D. melanogaster 61.4 929
XP_957586.2 ubiquitin ligase (Nedd4/Rsp5p) N. crassa 57.1 396
NP_011051.3 NEDD4 family E3 ubiquitin-protein ligase S. cerevisiae 53.5 611
XP_001689440.1 predicted protein C. reinhardtii 48.1 235
NP_001185245.1 ubiquitin-protein ligase 1 A. thaliana 46.1 232
Other hits (2 of 61) [Show all]SpeciesId(%)Len(aa)
XP_001088005.2 PREDICTED: e3 ubiquitin-protein ligase NEDD4 isoform 1 M. mulatta 99.0 1318
XP_003901026.1 PREDICTED: E3 ubiquitin-protein ligase NEDD4 P. anubis 97.9 1304

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; embryonic tissue; mixed; placenta; stomach; vascular; muscle; bone marrow; lung; bladder; uncharacterized tissue; mammary gland; brain; kidney; bone; adrenal gland; mouth; esophagus; blood; skin; testis; pituitary gland; eye; spinal cord; lymph node; uterus; salivary gland; trachea; lymph; ascites; connective tissue; intestine; heart; pancreas; ganglia; tonsil
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 15
Map position: 15q
UniSTS entry: Chr 15 STS-D42055
UniSTS entry: Chr 15 D15S1324 [Map Viewer]
UniSTS entry: Chr 15 RH25321 [Map Viewer]
UniSTS entry: Chr 15 MARC_17217-17218:1023895765:1
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (17)

BC047035.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone IMAGE:4525785), partial cds A
NM_006154.2 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), transcript variant 1, mRNA P
NM_198400.2 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), transcript variant 2, mRNA P
D42055.1 Homo sapiens KIAA0093 mRNA, partial cds P
AY550969.1 Homo sapiens cell proliferation-inducing protein 53 mRNA, complete cds P
BC152452.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone MGC:176705 IMAGE:8862584), complete cds PA
BC152562.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone MGC:167830 IMAGE:8860509), complete cds PA
AK307541.1 Homo sapiens cDNA, FLJ97489 P
AL833300.1 Homo sapiens mRNA; cDNA DKFZp451K129 (from clone DKFZp451K129) PA
AL833293.1 Homo sapiens mRNA; cDNA DKFZp451F249 (from clone DKFZp451F249) PA
AL832359.1 Homo sapiens mRNA; cDNA DKFZp451I206 (from clone DKFZp451I206) PA
AL832063.1 Homo sapiens mRNA; cDNA DKFZp313C0618 (from clone DKFZp313C0618) PA
AK304394.1 Homo sapiens cDNA FLJ54469 complete cds, highly similar to E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) P
BC144285.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone MGC:177822 IMAGE:9052805), complete cds P
BC144284.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone MGC:177821 IMAGE:9052804), complete cds P
BC136605.1 Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, mRNA (cDNA clone MGC:168218 IMAGE:9020595), complete cds P
BC035707.1 Homo sapiens, clone IMAGE:5575951, mRNA PA

EST sequences (10 of 204) [Show all sequences]

AI057300.1 Clone IMAGE:1673018 mixed 3' read A
AI094191.1 Clone IMAGE:1688163 mixed 3' read A
AI131164.1 Clone IMAGE:1709670 heart 3' read A
AI208374.1 Clone IMAGE:1839245 testis 3' read A
CB105501.1 Clone L1HLK1-5-C04 liver 5' read
CB105511.1 Clone L1HLK1-5-D05 liver 5' read
CB105513.1 Clone L1HLK1-5-D07 liver 5' read
CB105527.1 Clone L1HLK1-5-E11 liver 5' read
CB105531.1 Clone L1HLK1-5-F04 liver 5' read
CB105544.1 Clone L1HLK1-5-G08 liver 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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