Topoisomerase (DNA) II alpha 170kDa (TOP2A)

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UGID:154733 UniGene Hs.156346 Homo sapiens (human) TOP2A

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Topoisomerase (DNA) II alpha 170kDa (TOP2A)

SELECTED PROTEIN SIMILARITIES

Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.

Reference Protein		Species	Id(%)	Len(aa)
NP_001058.2	DNA topoisomerase II, alpha isozyme	H. sapiens	100.0	1530
NP_035753.2	topoisomerase (DNA) II alpha	M. musculus	95.7	1527
NP_001082502.1	hypothetical protein LOC398512	X. laevis	83.3	1578
NP_001003834.1	topoisomerase 2	D. rerio	80.4	1566
NP_476760.1	topoisomerase 2	D. melanogaster	69.9	1430
NP_496536.1	TOPoisomerase family member (top-2)	C. elegans	68.0	1453
XP_001700298.1	DNA topoisomerase II	C. reinhardtii	62.3	1149
NP_189031.1	TOPII (TOPOISOMERASE II); ATP binding / DNA binding / DNA topoisomerase (ATP-hydrolyzing)/ DNA topoisomerase/ DNA-dependent ATPase	A. thaliana	57.7	1470
NP_014311.1	Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; Top2p	S. cerevisiae	56.8	1362
XP_326193.1	hypothetical protein	N. crassa	52.9	1597

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	embryonic tissue; testis; liver; uncharacterized tissue; brain; mixed; intestine; uterus; heart; adrenal gland; connective tissue; lymph; spleen; prostate; ascites; skin; lymph node; bone; bladder; lung; stomach; eye; pancreas; mammary gland; kidney; thymus; muscle; placenta; mouth; blood; bone marrow; ovary; esophagus; cervix; vascular; salivary gland; pharynx; trachea; ear

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	17
Map position:	17q21-q22
UniSTS entry:	Chr 17	SHGC-31685
UniSTS entry:	Chr 17	SHGC-12497
UniSTS entry:	Chr 17	RH17658
UniSTS entry:		D17S1435E
UniSTS entry:	Chr 17	GDB:180937
UniSTS entry:	Chr 17	RH12872

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

NM_001067.2	Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A), mRNA	P
BC062677.1	Homo sapiens cDNA clone IMAGE:6388518, partial cds	A
CR625760.1	full-length cDNA clone CS0DB005YC15 of Neuroblastoma Cot 10-normalized of Homo sapiens (human)	P
AK024080.1	Homo sapiens cDNA FLJ14018 fis, clone HEMBA1001196, highly similar to Human DNA topoisomerase II (top2) mRNA	P
J04088.1	Human DNA topoisomerase II (top2) mRNA, complete cds	P
BC140791.1	Homo sapiens topoisomerase (DNA) II alpha 170kDa, mRNA (cDNA clone MGC:176468 IMAGE:9021659), complete cds	P
L47277.1	Homo sapiens (cell line HepG2, HeLa) alpha topoisomerase truncated-form mRNA, 3'UTR
L47276.1	Homo sapiens (cell line HL-60) alpha topoisomerase truncated-form mRNA, 3'UTR
BC013429.1	Homo sapiens topoisomerase (DNA) II alpha 170kDa, mRNA (cDNA clone IMAGE:4101949)	PA

EST sequences (10 of 707) [Show all sequences]

AA962007.1	Clone IMAGE:1593838	kidney	3' read	A
AA968782.1	Clone IMAGE:1593682	kidney	3' read	A
AI032284.1	Clone IMAGE:1644178	testis	3' read	A
AA948274.1	Clone IMAGE:1588205	uncharacterized tissue	3' read	P
AI076105.1	Clone IMAGE:1673294	mixed	3' read
AI076594.1	Clone IMAGE:1676904	embryonic tissue	3' read	A
AI092324.1	Clone IMAGE:1692593	heart	3' read	A
AI123885.1	Clone IMAGE:1692891	heart	3' read	A
AI127486.1	Clone IMAGE:1708284	heart	3' read	P
AI128799.1	Clone IMAGE:1694381	heart	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria