Topoisomerase (DNA) II alpha 170kDa (TOP2A)

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UGID:154733 UniGene Hs.156346 Homo sapiens (human) TOP2A

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Topoisomerase (DNA) II alpha 170kDa (TOP2A)

Human protein-coding gene TOP2A. Represented by 765 ESTs from 267 cDNA libraries. Corresponds to reference sequence NM_001067.3. [UniGene 154733 - Hs.156346]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001058.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	TOP2A gene product	H. sapiens	100.0	1530
XP_003315524.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha	P. troglodytes	99.7	1499
NP_035753.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Top2a gene product	M. musculus	95.7	1525
NP_001082502.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	topoisomerase (DNA) II alpha 170kDa	X. laevis	83.2	1578
NP_001003834.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	top2a gene product	D. rerio	80.3	1566
NP_476760.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	topoisomerase 2, isoform A	D. melanogaster	69.4	1430
NP_496536.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Protein TOP-2	C. elegans	67.6	1453
XP_001700298.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	DNA topoisomerase II	C. reinhardtii	61.5	1149
NP_014311.3 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	DNA topoisomerase 2	S. cerevisiae	60.5	1005
XP_962372.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	DNA topoisomerase 2	N. crassa	58.9	1023
NP_001118686.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	DNA topoisomerase 2	A. thaliana	58.1	1430
Other hits (2 of 62) [Show all]		Species	Id(%)	Len(aa)
XP_003913021.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: DNA topoisomerase 2-alpha isoform 1	P. anubis	99.2	1539
XP_002719184.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: DNA topoisomerase II, alpha isozyme-like	O. cuniculus	99.2	1180

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

	EST Profile:	Approximate expression patterns inferred from EST sources. [Show more entries with profiles like this]
	GEO Profiles:	Experimental gene expression data (Gene Expression Omnibus).
	cDNA Sources:	embryonic tissue; testis; liver; uncharacterized tissue; brain; mixed; intestine; lymph node; uterus; bone; mammary gland; lung; eye; kidney; skin; placenta; adrenal gland; pancreas; connective tissue; ovary; spleen; thymus; stomach; bladder; cervix; ear; ascites; heart; blood; prostate; mouth; vascular; lymph; muscle; bone marrow; esophagus; salivary gland; trachea; pharynx

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	17
Map position:	17q21-q22
UniSTS entry:	Chr 17	SHGC-31685	[Map Viewer]
UniSTS entry:	Chr 17	SHGC-12497	[Map Viewer]
UniSTS entry:	Chr 17	RH17658	[Map Viewer]
UniSTS entry:		D17S1435E
UniSTS entry:	Chr 17	GDB:180937
UniSTS entry:	Chr 17	RH12872	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

NM_001067.3	Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A), mRNA	P
BC062677.1	Homo sapiens cDNA clone IMAGE:6388518, partial cds	A
AK024080.1	Homo sapiens cDNA FLJ14018 fis, clone HEMBA1001196, highly similar to Human DNA topoisomerase II (top2) mRNA	P
J04088.1	Human DNA topoisomerase II (top2) mRNA, complete cds	P
BC140791.1	Homo sapiens topoisomerase (DNA) II alpha 170kDa, mRNA (cDNA clone MGC:176468 IMAGE:9021659), complete cds	P
L47277.1	Homo sapiens (cell line HepG2, HeLa) alpha topoisomerase truncated-form mRNA, 3'UTR
L47276.1	Homo sapiens (cell line HL-60) alpha topoisomerase truncated-form mRNA, 3'UTR
BC013429.1	Homo sapiens topoisomerase (DNA) II alpha 170kDa, mRNA (cDNA clone IMAGE:4101949)	PA

EST sequences (10 of 765) [Show all sequences]

AA962007.1	Clone IMAGE:1593838	kidney	3' read	A
AA968782.1	Clone IMAGE:1593682	kidney	3' read	A
AI032284.1	Clone IMAGE:1644178	testis	3' read	A
AI050686.1	Clone IMAGE:1639974	testis	3' read	A
AA948274.1	Clone IMAGE:1588205	uncharacterized tissue	3' read	P
AI076105.1	Clone IMAGE:1673294	mixed	3' read
AI076594.1	Clone IMAGE:1676904	embryonic tissue	3' read	A
AI092324.1	Clone IMAGE:1692593	heart	3' read	A
AI123885.1	Clone IMAGE:1692891	heart	3' read	A
AI127486.1	Clone IMAGE:1708284	heart	3' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria