SH2 domain containing 4B (SH2D4B)

Restricted Expression:

spleen [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

brain; testis; spleen; mixed

NCBI

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UGID:152706 UniGene Hs.147643 Homo sapiens (human) SH2D4B

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SH2 domain containing 4B (SH2D4B)

Human protein-coding gene SH2D4B. Represented by 11 ESTs from 8 cDNA libraries. EST representation biased toward spleen. Corresponds to 2 reference sequences (different isoforms). [UniGene 152706 - Hs.147643]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_997255.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	SH2D4B gene product	H. sapiens	100.0	356
NP_808484.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Sh2d4b gene product	M. musculus	92.7	328
XP_689048.4 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: SH2 domain-containing protein 4B-like	D. rerio	58.0	352
Other hits (2 of 17) [Show all]		Species	Id(%)	Len(aa)
XP_001153936.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: SH2 domain-containing protein 4B isoform 2	P. troglodytes	98.9	356
XP_003903738.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: SH2 domain-containing protein 4B isoform 1	P. anubis	96.9	356

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	10
Map position:	10q23.1
UniSTS entry:	Chr 10	SH2D4B__5396

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (5)

AK123978.1	Homo sapiens cDNA FLJ41984 fis, clone SPLEN2011422, weakly similar to CALDESMON	P
AK123885.1	Homo sapiens cDNA FLJ41891 fis, clone OCBBF2025028	P
NM_207372.2	Homo sapiens SH2 domain containing 4B (SH2D4B), transcript variant 1, mRNA	PA
AK091518.1	Homo sapiens cDNA FLJ34199 fis, clone FCBBF3019570
NM_001145719.1	Homo sapiens SH2 domain containing 4B (SH2D4B), transcript variant 2, mRNA	PA

EST sequences (11)

BX103545.1	Clone IMAGp998P144454_;_IMAGE:1752829	testis
AW511015.1	Clone IMAGE:2912176	mixed	3' read
DA180313.1	Clone BRAMY2044970	brain	5' read
DA504390.1	Clone FCBBF3019570	brain	5' read
DA787477.1	Clone OCBBF2025028	brain	5' read
DA938279.1	Clone SPLEN2011422	spleen	5' read	P
DB316020.1	Clone FCBBF3019570	brain	3' read	A
DB088096.1	Clone TESTI4036219	testis	5' read
DB332990.1	Clone SPLEN2011422	spleen	3' read	A
DB326463.1	Clone OCBBF2025028	brain	3' read	A
HY229935.1	Clone H04D153E08	testis

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria