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UGID:152206     UniGene Hs.146591     Homo sapiens (human)   BLK
B lymphoid tyrosine kinase (BLK)

Human protein-coding gene BLK. Represented by 115 ESTs from 38 cDNA libraries. EST representation biased toward adult. Corresponds to reference sequence NM_001715.2. [UniGene 152206 - Hs.146591]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001706.2 BLK gene product H. sapiens 100.0 504
NP_031575.2 Blk gene product M. musculus 91.2 498
NP_001025391.1 tyrosine-protein kinase Blk D. rerio 76.6 460
NP_001079115.1 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog X. laevis 69.5 471
NP_476849.1 Src oncogene at 42A, isoform A D. melanogaster 57.8 483
NP_493502.1 Protein SRC-2 C. elegans 53.0 466
Other hits (2 of 42) [Show all]SpeciesId(%)Len(aa)
XP_003317961.1 PREDICTED: tyrosine-protein kinase Blk P. troglodytes 99.2 504
XP_003902465.1 PREDICTED: tyrosine-protein kinase Blk P. anubis 98.2 504

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lymph; uncharacterized tissue; spleen; lung; tonsil; lymph node; mixed; salivary gland; thyroid; connective tissue; thymus; intestine; blood; bone marrow; pancreas; pharynx; testis; mammary gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p23-p22
UniSTS entry: GDB:462442
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

NM_001715.2 Homo sapiens B lymphoid tyrosine kinase (BLK), mRNA PA
AK131319.1 Homo sapiens cDNA FLJ16316 fis, clone SPLEN2033490
BC004473.2 Homo sapiens B lymphoid tyrosine kinase, mRNA (cDNA clone IMAGE:3939418) A
BC007371.2 Homo sapiens B lymphoid tyrosine kinase, mRNA (cDNA clone MGC:16168 IMAGE:3634568), complete cds PA
Z33998.1 H.sapiens mRNA for human lymphoid tyrosine kinase related to murine Blk P
AK313751.1 Homo sapiens cDNA, FLJ94352, highly similar to Homo sapiens B lymphoid tyrosine kinase (BLK), mRNA P
BC032413.1 Homo sapiens B lymphoid tyrosine kinase, mRNA (cDNA clone MGC:40359 IMAGE:5216030), complete cds PA
AL832875.1 Homo sapiens mRNA; cDNA DKFZp667H093 (from clone DKFZp667H093) PA
BC018703.1 Homo sapiens B lymphoid tyrosine kinase, mRNA (cDNA clone IMAGE:4574968), partial cds PA
S76617.1 blk=protein tyrosine kinase [human, B lymphocytes, mRNA, 2608 nt] PA
BC038555.1 Homo sapiens B lymphoid tyrosine kinase, mRNA (cDNA clone IMAGE:3939419) A

EST sequences (10 of 115) [Show all sequences]

AI014559.1 Clone IMAGE:1628788 mixed 3' read A
AI084074.1 Clone IMAGE:1671363 uncharacterized tissue 3' read A
BX095875.1 Clone IMAGp998I095292_;_IMAGE:2143952 pancreas A
AI379972.1 Clone IMAGE:2072554 uncharacterized tissue 3' read A
AI453244.1 Clone IMAGE:2143952 pancreas 3' read
AI475734.1 Clone IMAGE:2073071 uncharacterized tissue 3' read A
AI494631.1 Clone IMAGE:2021766 uncharacterized tissue 3' read PA
AI760570.1 Clone IMAGE:2387858 uncharacterized tissue 3' read A
AI760869.1 Clone IMAGE:2389737 uncharacterized tissue 3' read
AI766696.1 Clone IMAGE:2389029 uncharacterized tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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