Glycine N-methyltransferase (GNMT)

Restricted Expression:

liver tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

liver; mixed; prostate; spleen; lung; testis; kidney; uncharacterized tissue; thymus; blood; pancreas

NCBI

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Finding cDNAs

UGID:151629 UniGene Hs.144914 Homo sapiens (human) GNMT

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Glycine N-methyltransferase (GNMT)

Human protein-coding gene GNMT. Represented by 67 ESTs from 19 cDNA libraries. EST representation biased toward liver tumor. Corresponds to reference sequence NM_018960.4. [UniGene 151629 - Hs.144914]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
XP_518481.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: glycine N-methyltransferase	P. troglodytes	100.0	294
NP_061833.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	GNMT gene product	H. sapiens	100.0	294
NP_034451.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	glycine N-methyltransferase	M. musculus	93.5	292
NP_997981.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	gnmt gene product	D. rerio	80.9	293
NP_650223.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	CG6188	D. melanogaster	67.6	281
Other hits (2 of 31) [Show all]		Species	Id(%)	Len(aa)
XP_001089876.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: glycine N-methyltransferase	M. mulatta	99.3	294
XP_003897660.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: glycine N-methyltransferase	P. anubis	99.0	294

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	6
Map position:	6p12
UniSTS entry:	Chr 6	GNMT
UniSTS entry:	Chr 6	G64272
UniSTS entry:	Chr 1	D11S2921
UniSTS entry:	Chr 1	D11S3114

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (4)

NM_018960.4	Homo sapiens glycine N-methyltransferase (GNMT), mRNA	PA
AF101477.1	Homo sapiens glycine N-methyltransferase (GNMT) mRNA, complete cds	PA
BC032627.1	Homo sapiens glycine N-methyltransferase, mRNA (cDNA clone MGC:45044 IMAGE:5229272), complete cds	PA
AK092088.1	Homo sapiens cDNA FLJ34769 fis, clone NT2NE2002856

EST sequences (10 of 67) [Show all sequences]

AI074613.1	Clone IMAGE:1673972	mixed	3' read	P
AI202588.1	Clone IMAGE:1943206	prostate	3' read	A
AI566506.1	Clone IMAGE:2222735	pancreas	3' read	A
AI660395.1	Clone IMAGE:2345693	thymus	3' read
BX282602.1	Clone IMAGp998J214249_;_IMAGE:1673972	mixed		P
CF144914.1	Clone IMAGE:30568937	prostate	5' read	P
CD629536.1		uncharacterized tissue		P
CD629537.1		uncharacterized tissue		P
BP872528.2	Clone HKR07637	kidney	5' read	P
CV030736.1		mixed	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria