Cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)

Restricted Expression:

liver tumor [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

mixed; liver; mammary gland

NCBI

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UGID:130986 UniGene Hs.1361 Homo sapiens (human) CYP1A2

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Cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)

Human protein-coding gene CYP1A2. Represented by 26 ESTs from 7 cDNA libraries. EST representation biased toward liver tumor. Corresponds to reference sequence NM_000761.3. [UniGene 130986 - Hs.1361]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_000752.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	CYP1A2 gene product	H. sapiens	100.0	515
NP_034123.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Cyp1a2 gene product	M. musculus	75.2	512
NP_001090541.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cytochrome P450, family 1, subfamily A, polypeptide 1	X. laevis	63.5	508
NP_571954.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	cyp1a gene product	D. rerio	59.5	499
Other hits (2 of 32) [Show all]		Species	Id(%)	Len(aa)
XP_001135509.2 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: cytochrome P450 1A2-like, partial	P. troglodytes	95.5	487
XP_003901256.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: cytochrome P450 1A2-like	P. anubis	93.2	515

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	15
Map position:	15q24.1
UniSTS entry:	Chr 15	STS-M31667
UniSTS entry:	Chr 1	PMC156606P1
UniSTS entry:	Chr 15	SGC35304	[Map Viewer]
UniSTS entry:	Chr 1	RH80030
UniSTS entry:	Chr 1	GDB:631802
UniSTS entry:	Chr 15	G10504
UniSTS entry:	Chr 1	D8S2279

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

NM_000761.3	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2), mRNA	P
BC067428.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79254 IMAGE:7002128), complete cds	P
BC067426.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79252 IMAGE:7002125), complete cds	P
BC067429.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79255 IMAGE:7002129), complete cds	P
BC067424.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79250 IMAGE:7002123), complete cds	P
BC067427.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79253 IMAGE:7002126), complete cds	P
BC067425.1	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2, mRNA (cDNA clone MGC:79251 IMAGE:7002124), complete cds	P
M55053.1	Human cytochrome P-3-450 mRNA, complete cds	P
AF182274.1	Homo sapiens cytochrome P450-1A2 (CYP1A2) mRNA, complete cds	P
Z00036.1	Human mRNA for cytochrome P-3-450	P
M12078.1	Human cytochrome P-450 4 mRNA, partial cds	P

EST sequences (10 of 26) [Show all sequences]

CB115370.1	Clone L7N800102-10-B02	liver	5' read	P
CF271967.2	Clone IMAGE:7002129	mixed	5' read	P
CF271975.1	Clone IMAGE:7002124	mixed	5' read	P
CF271976.2	Clone IMAGE:7002124	mixed	5' read	P
CF271977.2	Clone IMAGE:7002123	mixed	5' read	P
CF271978.2	Clone IMAGE:7002123	mixed	5' read	P
CF271973.1	Clone IMAGE:7002125	mixed	5' read	P
CF271968.1	Clone IMAGE:7002129	mixed	5' read	P
CF271969.2	Clone IMAGE:7002128	mixed	5' read	P
CF271970.2	Clone IMAGE:7002128	mixed	5' read	P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria