> Tropomyosin 1 (alpha) (TPM1)
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UGID:149994     UniGene Hs.133892     Homo sapiens (human)   TPM1 Order cDNA clone, Links
Tropomyosin 1 (alpha) (TPM1)

Human protein-coding gene TPM1. Represented by 2058 ESTs from 458 cDNA libraries. Corresponds to 7 reference sequences (different isoforms). [UniGene 149994 - Hs.133892]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001103298.1 PREDICTED: tropomyosin alpha-4 chain isoform 9 M. mulatta 100.0 325
XP_003901074.1 PREDICTED: tropomyosin alpha-4 chain P. anubis 100.0 325
NP_001157720.1 Tpm1 gene product M. musculus 100.0 283
NP_001029241.1 Tpm1 gene product R. norvegicus 100.0 283
XP_001366077.1 PREDICTED: tropomyosin alpha-4 chain-like isoform 6 M. domestica 100.0 283
XP_001173748.1 PREDICTED: tropomyosin alpha-1 chain isoform 24 P. troglodytes 100.0 283
NP_001018004.1 TPM1 gene product H. sapiens 100.0 283
XP_864999.1 PREDICTED: tropomyosin alpha-4 chain isoform 11 C. lupus familiaris 100.0 283
NP_001099158.1 LOC100125989 gene product O. cuniculus 100.0 283
NP_001013608.1 TPM1 gene product B. taurus 99.7 283
NP_001119823.1 TPM1 gene product O. aries 99.7 283
NP_571180.1 tpma gene product D. rerio 95.1 283
NP_001128548.1 tropomyosin 1 (alpha) X. laevis 95.1 283
NP_001021695.1 Protein LEV-11, isoform a C. elegans 64.9 282
NP_732002.1 tropomyosin 1, isoform M D. melanogaster 61.2 281
Other hits (2 of 29) [Show all]SpeciesId(%)Len(aa)
NP_001129953.1 TPM1 gene product T. guttata 97.2 283
XP_003209411.1 PREDICTED: tropomyosin alpha-1 chain-like isoform 2 M. gallopavo 96.8 283

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: heart; embryonic tissue; muscle; brain; placenta; liver; intestine; uterus; eye; kidney; prostate; vascular; lung; stomach; uncharacterized tissue; pancreas; testis; skin; bone; mixed; mammary gland; umbilical cord; epididymis; ear; mouth; esophagus; salivary gland; spleen; thyroid; ovary; pituitary gland; blood; bladder; pharynx; adipose tissue; lymph node; connective tissue; cervix; amniotic fluid; nerve; thymus; ganglia; bone marrow; ascites; trachea; adrenal gland; spinal cord; larynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 15
Map position: 15q22.1
UniSTS entry: Chr 15 A006I38
UniSTS entry: Chr 15 G20856
UniSTS entry: Chr 15 RH69090
UniSTS entry: Chr 15 SHGC-31495
UniSTS entry: Chr 15 SHGC-12376 [Map Viewer]
UniSTS entry: Chr 15 G30945
UniSTS entry: Chr 15 RH92957
UniSTS entry: RH70111
UniSTS entry: D10S2366
UniSTS entry: RH44940
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (36)

BC050473.1 Homo sapiens tropomyosin 1 (alpha), mRNA (cDNA clone IMAGE:5732846), partial cds PA
AL050179.1 Homo sapiens mRNA; cDNA DKFZp586K2222 (from clone DKFZp586K2222) PA
BC053545.1 Homo sapiens tropomyosin 1 (alpha), mRNA (cDNA clone MGC:61803 IMAGE:5730451), complete cds PA
BX648171.1 Homo sapiens mRNA; cDNA DKFZp686K239 (from clone DKFZp686K239) A
AK129882.1 Homo sapiens cDNA FLJ26372 fis, clone HRT06233 P
NM_000366.5 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 5, mRNA PA
AK131384.1 Homo sapiens cDNA FLJ16459 fis, clone BRCAN2002473, moderately similar to Tropomyosin, fibroblast isoform 2 P
AY640415.1 Homo sapiens tropomyosin alpha striated muscle isoform (TPM1) mRNA, complete cds; alternatively spliced P
AY640414.1 Homo sapiens sarcomeric tropomyosin kappa (TPM1) mRNA, complete cds; alternatively spliced P
AB209041.1 Homo sapiens mRNA for TPM1 protein variant protein P
NM_001018020.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 7, mRNA PA
NM_001018008.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 6, mRNA P
NM_001018007.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 2, mRNA PA
NM_001018006.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 4, mRNA PA
NM_001018005.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 1, mRNA PA
NM_001018004.1 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 3, mRNA PA
DQ424903.1 Homo sapiens clone FG060306 tropomyosin 1 alpha variant 6 mRNA, complete cds, alternatively spliced P
M19713.1 Human skeletal muscle alpha-tropomyosin (hTM-alpha) mRNA, complete cds PA
M19714.1 Human skeletal muscle alpha-tropomyosin gene (hTM-alpha) mRNA, 3' end P
M19715.1 Human skeletal muscle alpha-tropomyosin (hTM-alpha) mRNA, 3' end P
BC007433.2 Homo sapiens tropomyosin 1 (alpha), mRNA (cDNA clone MGC:4021 IMAGE:2962925), complete cds PA
AK057989.1 Homo sapiens cDNA FLJ25260 fis, clone STM04650, highly similar to TROPOMYOSIN, FIBROBLAST ISOFORM 2 P
AK055197.1 Homo sapiens cDNA FLJ30635 fis, clone CTONG2002520
AK309170.1 Homo sapiens cDNA, FLJ99211 P
AK094175.1 Homo sapiens cDNA FLJ36856 fis, clone ASTRO2014863
AK092573.1 Homo sapiens cDNA FLJ35254 fis, clone PROST2003775, highly similar to TROPOMYOSIN, FIBROBLAST ISOFORM TM3 P
AF474156.1 Homo sapiens TPMsk1 (TPM1) mRNA, partial cds P
AL358752.1 Homo sapiens EST from clone 545144, 5' end
L02923.1 Human tropomyosin isoform hTMsma mRNA, exon 2
AK301319.1 Homo sapiens cDNA FLJ54760 complete cds, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 7, mRNA P
AK299387.1 Homo sapiens cDNA FLJ58853 complete cds, highly similar to Tropomyosin 1 alpha chain P
AK298625.1 Homo sapiens cDNA FLJ55130 complete cds, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 8, mRNA P
Z24727.1 H.sapiens tropomyosin isoform mRNA, complete CDS P
X12369.1 Human mRNA (exon 6-9 part.) for smooth muscle tropomyosin P
AJ000147.1 Homo sapiens mRNA for alpha-tropomyosin (3' end) A
AJ001055.1 Homo sapiens mRNA for alpha-tropomyosin A

EST sequences (10 of 2058) [Show all sequences]

R15972.1 Clone IMAGE:53242 brain 3' read A
R15973.1 Clone IMAGE:53242 brain 5' read
AA976487.1 Clone IMAGE:1591802 kidney 3' read A
AA985408.1 Clone IMAGE:1592825 kidney 3' read A
AA991533.1 Clone IMAGE:1609678 mammary gland 3' read
AA992675.1 Clone IMAGE:1623203 embryonic tissue 3' read A
R16635.1 Clone IMAGE:129658 mixed 5' read
AA996250.1 Clone IMAGE:1605697 kidney 3' read A
AA999872.1 Clone IMAGE:1636401 kidney 3' read A
AI003950.1 Clone IMAGE:1624405 embryonic tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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