> GNAS complex locus (GNAS)
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UGID:147161     UniGene Hs.125898     Homo sapiens (human)   GNAS Links
GNAS complex locus (GNAS)

Human protein-coding gene GNAS. Represented by 5451 ESTs from 894 cDNA libraries. Corresponds to 8 reference sequences (different isoforms). [UniGene 147161 - Hs.125898]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_536350.2 GNAS gene product H. sapiens 100.0 1036
NP_001165455.1 guanine nucleotide-binding protein G(s) subunit alpha isoform f S. scrofa 100.0 394
NP_001003263.1 GNAS gene product C. lupus familiaris 100.0 393
NP_851364.1 GNAS gene product B. taurus 100.0 393
XP_004014482.1 PREDICTED: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like isoform 1 O. aries 100.0 334
XP_001138016.3 PREDICTED: LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform 5 P. troglodytes 99.5 429
NP_001095223.1 guanine nucleotide-binding protein G(s) subunit alpha X. laevis 96.3 378
NP_999968.2 guanine nucleotide-binding protein G(olf) subunit alpha D. rerio 88.2 398
NP_477506.1 G protein salpha 60A, isoform A D. melanogaster 81.9 381
NP_034439.2 Gnas gene product M. musculus 78.8 1132
NP_490817.3 Protein GSA-1 C. elegans 78.1 374
XP_957133.1 guanine nucleotide-binding protein alpha subunit N. crassa 51.3 341
Other hits (2 of 46) [Show all]SpeciesId(%)Len(aa)
XP_003227362.1 PREDICTED: guanine nucleotide-binding protein G(s) subunit alpha isoforms short-like isoform 2 A. carolinensis 98.0 393
XP_003444815.1 PREDICTED: guanine nucleotide-binding protein G(s) subunit alpha-like isoform 2 O. niloticus 96.6 379

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: pancreas; brain; thyroid; embryonic tissue; mouth; lung; testis; uterus; mammary gland; eye; intestine; uncharacterized tissue; pituitary gland; bone; placenta; mixed; stomach; kidney; larynx; prostate; skin; ovary; muscle; liver; blood; lymph node; cervix; adrenal gland; heart; connective tissue; lymph; ascites; ear; nerve; pharynx; bone marrow; trachea; bladder; ganglia; thymus; vascular; parathyroid; amniotic fluid; pineal gland; epididymis; spleen; umbilical cord; adipose tissue; esophagus; salivary gland; tonsil; peritoneum
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 20
Map position: 20q13.3
UniSTS entry: Chr 20 RH11717 [Map Viewer]
UniSTS entry: Chr 20 GNAS1
UniSTS entry: Chr 20 GDB:393268
UniSTS entry: Chr 20 MARC_5561-5562:1031675650:1
UniSTS entry: Chr 20 Gnas
UniSTS entry: D20S541E
UniSTS entry: Chr 20 PMC301417P2
UniSTS entry: Chr 20 RH93711
UniSTS entry: Chr 20 SHGC-58255
UniSTS entry: Chr 20 RH75699
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (37)

AF064092.1 Homo sapiens mutant guanine nucleotide-binding protein G(s), alpha subunit mRNA, complete cds P
AF088184.1 Homo sapiens guanine nucleotide-binding protein Gs alpha subunit isoform L2 mRNA, complete cds
AF088185.1 Homo sapiens guanine nucleotide-binding protein Gs alpha subunit isoform L3 mRNA, complete cds
BT009905.1 Homo sapiens GNAS complex locus mRNA, complete cds P
AK122771.1 Homo sapiens cDNA FLJ16311 fis, clone SPLEN2010187, highly similar to GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ALPHA SUBUNIT PA
NM_000516.4 Homo sapiens GNAS complex locus (GNAS), transcript variant 1, mRNA PA
BC066923.1 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:4814812), complete cds PA
AF105253.1 Homo sapiens neuroendocrine secretory protein 55 mRNA, complete cds PA
NM_016592.2 Homo sapiens GNAS complex locus (GNAS), transcript variant 4, mRNA PA
M14631.1 Human guanine nucleotide-binding protein G-s, alpha subunit mRNA, partial cds P
BC089157.1 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:6647888), complete cds PA
BC036081.1 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:5302402), containing frame-shift errors PA
AK026564.1 Homo sapiens cDNA: FLJ22911 fis, clone KAT05860, highly similar to HSGSA2R Human mRNA for coupling protein G(s) alpha subunit (alpha-S2) (stimulatory regulatory component Gs of adenylyl cyclase) PA
BC108315.1 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:6092583), complete cds PA
BC104928.1 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:8143931), complete cds P
BC002722.2 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:3627815), complete cds PA
AK225818.1 Homo sapiens mRNA for guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform b variant, clone: FCC129A01 P
NM_001077490.1 Homo sapiens GNAS complex locus (GNAS), transcript variant 2, mRNA PA
NM_001077489.2 Homo sapiens GNAS complex locus (GNAS), transcript variant 7, mRNA PA
NM_001077488.2 Homo sapiens GNAS complex locus (GNAS), transcript variant 6, mRNA PA
BC008855.2 Homo sapiens GNAS complex locus, mRNA (cDNA clone IMAGE:4106768), complete cds PA
X56009.1 Human GSA mRNA for alpha subunit of GsGTP binding protein PA
AK054862.1 Homo sapiens cDNA FLJ30300 fis, clone BRACE2003210, highly similar to GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ALPHA SUBUNIT P
NM_080426.2 Homo sapiens GNAS complex locus (GNAS), transcript variant 3, mRNA PA
NM_080425.2 Homo sapiens GNAS complex locus (GNAS), transcript variant 2, mRNA PA
AK314549.1 Homo sapiens cDNA, FLJ95373, Homo sapiens GNAS complex locus (GNAS), transcript variant 4, mRNA
AK315874.1 Homo sapiens cDNA, FLJ79523 complete cds, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha PA
AK315860.1 Homo sapiens cDNA, FLJ79509 complete cds, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha P
BC022875.1 Homo sapiens, Similar to GNAS complex locus, clone IMAGE:4108909, mRNA, partial cds PA
AF493898.1 Homo sapiens guanine nucleotide binding protein alpha s short (GNASS) mRNA, complete cds P
AF493897.1 Homo sapiens guanine nucleotide binding protein alpha s long (GNASL) mRNA, complete cds P
AK093534.1 Homo sapiens cDNA FLJ36215 fis, clone THYMU2000684, highly similar to Guanine nucleotide-binding protein G-s-alpha-4 P
X04409.1 Human mRNA for coupling protein G(s) alpha-subunit (alpha-S1) (stimulatory regulatory component Gs of adenylyl cyclase) P
X04408.1 Human mRNA for coupling protein G(s) alpha subunit (alpha-S2) (stimulatory regulatory component Gs of adenylyl cyclase) P
X07036.1 Human mRNA stimulatory GTP-binding protein alpha subunit P
M77026.1 Homo sapiens adenyl cyclase mRNA P
NR_003259.1 Homo sapiens GNAS complex locus (GNAS), transcript variant 8, non-coding RNA PA

EST sequences (10 of 5451) [Show all sequences]

AA863463.1 Clone IMAGE:1469382 uncharacterized tissue 3' read A
AA865955.1 Clone IMAGE:1459161 kidney 3' read A
AA961572.1 Clone IMAGE:1592629 kidney 3' read A
AA962002.1 Clone IMAGE:1593824 kidney 3' read A
AA902940.1 Clone IMAGE:1516768 uncharacterized tissue 3' read A
AA903092.1 Clone IMAGE:1517030 uncharacterized tissue 3' read A
AA970200.1 Clone IMAGE:1575147 kidney 3' read A
AA976193.1 Clone IMAGE:1558524 lung 3' read P
AA977403.1 Clone IMAGE:1590610 kidney 3' read A
AA989161.1 Clone IMAGE:1593519 kidney 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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