> Mixed lineage kinase domain-like (MLKL)
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UGID:145506     UniGene Hs.119878     Homo sapiens (human)   MLKL Order cDNA clone, Links
Mixed lineage kinase domain-like (MLKL)

Human protein-coding gene MLKL. Represented by 106 ESTs from 78 cDNA libraries. EST representation biased toward neonate. Corresponds to 2 reference sequences (different isoforms). [UniGene 145506 - Hs.119878]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_689862.1 MLKL gene product H. sapiens 100.0 470
NP_083281.1 Mlkl gene product M. musculus 67.9 463
Other hits (2 of 15) [Show all]SpeciesId(%)Len(aa)
XP_001137657.1 PREDICTED: mixed lineage kinase domain-like isoform 2 P. troglodytes 98.7 470
XP_003917222.1 PREDICTED: mixed lineage kinase domain-like protein P. anubis 93.0 469

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; uterus; vascular; mammary gland; pancreas; connective tissue; kidney; larynx; bone marrow; blood; liver; cervix; placenta; brain; uncharacterized tissue; mixed; mouth; heart; spleen; intestine; prostate; trachea; thymus; eye; ascites; bone; umbilical cord; adipose tissue; muscle; pharynx; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 16
Map position: 16q23.1
UniSTS entry: Chr 16 RH69740 [Map Viewer]
UniSTS entry: Chr 1 SHGC-67307
UniSTS entry: Chr 1 GDB:434012
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (7)

AK122998.1 Homo sapiens cDNA FLJ16776 fis, clone BRHIP2002510 P
BC028141.1 Homo sapiens mixed lineage kinase domain-like, mRNA (cDNA clone MGC:40065 IMAGE:5214733), complete cds PA
AK093013.1 Homo sapiens cDNA FLJ35694 fis, clone SPLEN2019575
AK091708.1 Homo sapiens cDNA FLJ34389 fis, clone HCHON2000087 P
AL833362.1 Homo sapiens mRNA; cDNA DKFZp667E1714 (from clone DKFZp667E1714) PA
NM_152649.2 Homo sapiens mixed lineage kinase domain-like (MLKL), transcript variant 1, mRNA PA
NM_001142497.1 Homo sapiens mixed lineage kinase domain-like (MLKL), transcript variant 2, mRNA PA

EST sequences (10 of 106) [Show all sequences]

AA862772.1 Clone IMAGE:1469162 uncharacterized tissue 3' read A
CB069290.1 Clone IMAGE:6365056 pancreas 3' read A
BX106138.1 Clone IMAGp998C17120_;_IMAGE:123976 mixed A
CB159407.1 Clone L18POOL1n1-40-D01 liver 5' read P
AI351962.1 Clone IMAGE:1933338 mixed 3' read A
AI471283.1 Clone IMAGE:2156090 intestine 3' read A
CB528830.1 Clone UI-H-FT2-bje-e-14-0-UI lung 3' read A
BX352121.2 Clone CS0DI080YI11 placenta 3' read
BX372158.1 Clone CS0DK010YJ20 cervix 3' read P
BX384495.2 Clone CS0DK010YJ20 cervix 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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