Glycoprotein hormones, alpha polypeptide (CGA)

Restricted Expression:

pituitary gland [show more like this]

EST Profile:

Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]

GEO Profiles:

Experimental gene expression data (Gene Expression Omnibus).

cDNA Sources:

placenta; pituitary gland; mixed; stomach; ear; connective tissue; skin; liver; brain; embryonic tissue; thyroid; lung; heart; uncharacterized tissue; vascular; muscle; mammary gland

NCBI

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Finding cDNAs

UGID:145472 UniGene Hs.119689 Homo sapiens (human) CGA

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Glycoprotein hormones, alpha polypeptide (CGA)

Human protein-coding gene CGA. Represented by 1009 ESTs from 59 cDNA libraries. EST representation biased toward pituitary gland. Corresponds to 2 reference sequences (different isoforms). [UniGene 145472 - Hs.119689]

SELECTED PROTEIN SIMILARITIES

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms		Species	Id(%)	Len(aa)
NP_001239312.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	CGA gene product	H. sapiens	100.0	146
NP_034019.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	Cga gene product	M. musculus	75.8	119
NP_001085173.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	glycoprotein hormones, alpha polypeptide precursor	X. laevis	67.2	121
Other hits (2 of 17) [Show all]		Species	Id(%)	Len(aa)
XP_003950934.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: glycoprotein hormones alpha chain	P. troglodytes	98.0	146
XP_001090917.1 Conserved domains (CDD) Gene summary Protein sequence Protein/EST matches (ProtEST) Protein/protein matches (BLink)	PREDICTED: glycoprotein hormones alpha chain-like	M. mulatta	83.3	119

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

Chromosome:	6
Map position:	6q12-q21
UniSTS entry:	Chr 6	RH78136
UniSTS entry:	Chr 6	D6S1845	[Map Viewer]

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

BC055080.1	Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:62040 IMAGE:4044086), complete cds	PA
NM_000735.3	Homo sapiens glycoprotein hormones, alpha polypeptide (CGA), transcript variant 2, mRNA	PA
CR457427.1	Homo sapiens full open reading frame cDNA clone RZPDo834A0815D for gene CGA, glycoprotein hormones, alpha polypeptide; complete cds, incl. stopcodon	P
AK023644.1	Homo sapiens cDNA FLJ13582 fis, clone PLACE1009048
V00518.1	Human messenger RNA for chorionic gonadotropin	P
BC010957.1	Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:13639 IMAGE:4043527), complete cds	PA
BC020782.1	Homo sapiens glycoprotein hormones, alpha polypeptide, mRNA (cDNA clone MGC:22783 IMAGE:4732686), complete cds	PA
AK311972.1	Homo sapiens cDNA, FLJ92245, Homo sapiens glycoprotein hormones, alpha polypeptide (CGA), mRNA	P
AB019569.1	Homo sapiens mRNA expressed only in placental villi, clone SMAP84
FJ624079.1	Homo sapiens clone F1-351a follicle-stimulating hormone alpha subunit (CGA) mRNA, complete cds	P
FJ624078.1	Homo sapiens clone F2-351a follicle-stimulating hormone alpha subunit (CGA) mRNA, partial cds	P
NM_001252383.1	Homo sapiens glycoprotein hormones, alpha polypeptide (CGA), transcript variant 1, mRNA	PA

EST sequences (10 of 1009) [Show all sequences]

AI033957.1	Clone IMAGE:1655856	mixed	3' read	PA
R22986.1	Clone IMAGE:131384	placenta	3' read	A
R23095.1	Clone IMAGE:131384	placenta	5' read	P
R23453.1	Clone IMAGE:132075	placenta	5' read
R23843.1	Clone IMAGE:132966	placenta	5' read	P
AI148663.1	Clone IMAGE:1714860	placenta	3' read	A
BX115894.1	Clone IMAGp998N09473_;_IMAGE:234440	mixed		PA
AI189849.1	Clone IMAGE:1724594	placenta	3' read	P
R26052.1	Clone IMAGE:132075	placenta	3' read	A
R26889.1	Clone IMAGE:133405	placenta	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria