> Anterior pharynx defective 1 homolog A (C. elegans) (APH1A)
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UGID:143852     UniGene Hs.108408     Homo sapiens (human)   APH1A Order cDNA clone, Links
Anterior pharynx defective 1 homolog A (C. elegans) (APH1A)

Human protein-coding gene APH1A. Represented by 1057 ESTs from 358 cDNA libraries. Corresponds to 7 reference sequences (different isoforms). [UniGene 143852 - Hs.108408]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_666246.1 Aph1a gene product M. musculus 100.0 264
XP_001100088.1 PREDICTED: gamma-secretase subunit APH-1A isoform 4 M. mulatta 100.0 264
XP_003892624.1 PREDICTED: gamma-secretase subunit APH-1A P. anubis 100.0 264
XP_513772.1 PREDICTED: gamma-secretase subunit APH-1A isoform 5 P. troglodytes 100.0 264
NP_001071096.1 APH1A gene product H. sapiens 100.0 264
XP_003639673.1 PREDICTED: gamma-secretase subunit APH-1A-like isoform 1 C. lupus familiaris 100.0 264
XP_001489214.1 PREDICTED: gamma-secretase subunit APH-1A-like isoform 1 E. caballus 100.0 264
XP_004002492.1 PREDICTED: gamma-secretase subunit APH-1A isoform 1 O. aries 100.0 264
XP_002715647.1 PREDICTED: anterior pharynx defective 1 homolog A O. cuniculus 100.0 264
NP_001014277.1 Aph1a gene product R. norvegicus 100.0 246
NP_001231416.1 APH1A gene product S. scrofa 100.0 246
NP_001029842.1 APH1A gene product B. taurus 100.0 246
NP_001089056.1 anterior pharynx defective 1 homolog A X. laevis 83.0 246
NP_956409.1 aph1b gene product D. rerio 68.9 251
NP_608710.1 anterior pharynx defective 1, isoform A D. melanogaster 49.4 232
Other hits (2 of 24) [Show all]SpeciesId(%)Len(aa)
XP_001370546.1 PREDICTED: gamma-secretase subunit APH-1A-like M. domestica 97.4 264
XP_428797.3 PREDICTED: gamma-secretase subunit APH-1A-like G. gallus 85.3 264

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; intestine; placenta; lung; mixed; uncharacterized tissue; skin; mammary gland; testis; blood; uterus; prostate; kidney; eye; thymus; embryonic tissue; amniotic fluid; cervix; bladder; parathyroid; stomach; liver; connective tissue; ovary; lymph; pharynx; ascites; bone; esophagus; trachea; thyroid; heart; spleen; pancreas; adipose tissue; bone marrow; umbilical cord; vascular; muscle; mouth; adrenal gland; larynx; epididymis; lymph node; nerve; ganglia
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1p36.13-q31.3
UniSTS entry: Chr 1 A004F41
UniSTS entry: Chr 1 SGC31751 [Map Viewer]
UniSTS entry: Chr 1 MARC_7139-7140:996687542:1
UniSTS entry: Chr 1 D13S1659
UniSTS entry: Chr 15 Rnu2
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (27)

AY358951.1 Homo sapiens clone DNA59625 GAAV579 (UNQ579) mRNA, complete cds PA
NM_016022.3 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 2, mRNA PA
AF151835.1 Homo sapiens CGI-78 protein mRNA, complete cds P
BC001230.2 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:4880 IMAGE:3457593), complete cds PA
NM_001077628.2 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 1, mRNA PA
AK027879.1 Homo sapiens cDNA FLJ14973 fis, clone THYRO1001134, highly similar to Gamma-secretase subunit APH-1A P
BC008732.2 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:706 IMAGE:3162330), complete cds PA
BC009501.2 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:16536 IMAGE:4040230), complete cds PA
BC015568.2 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:22981 IMAGE:3356401), complete cds PA
BC017699.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:21097 IMAGE:4177580), complete cds PA
BC020590.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans), mRNA (cDNA clone MGC:22065 IMAGE:4420942), complete cds PA
AK314490.1 Homo sapiens cDNA, FLJ95300 P
AK307358.1 Homo sapiens cDNA, FLJ97306 PA
AK300640.1 Homo sapiens cDNA FLJ60161 complete cds, moderately similar to Gamma-secretase subunit APH-1A P
AK297680.1 Homo sapiens cDNA FLJ52697 complete cds, highly similar to Gamma-secretase subunit APH-1A P
AK298876.1 Homo sapiens cDNA FLJ60800 complete cds, moderately similar to Gamma-secretase subunit APH-1A PA
AK298832.1 Homo sapiens cDNA FLJ52724 complete cds, highly similar to Gamma-secretase subunit APH-1A PA
AK075452.1 Homo sapiens cDNA PSEC0144 fis, clone PLACE1006610, highly similar to Gamma-secretase subunit APH-1A P
AK075295.1 Homo sapiens cDNA FLJ90814 fis, clone Y79AA1001013, highly similar to Gamma-secretase subunit APH-1A P
NM_001243771.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 3, mRNA PA
NM_001243772.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 4, mRNA PA
NR_045033.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 5, non-coding RNA PA
NR_045034.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 6, non-coding RNA PA
NR_045035.1 Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 7, non-coding RNA PA
AF508787.1 Homo sapiens presenilin stabilization factor (PSF) mRNA, complete cds PA
AY113699.1 Homo sapiens presenilin stabilization factor b (PSF) mRNA, complete cds; alternatively spliced P
AY113698.1 Homo sapiens presenilin stabilization factor a (PSF) mRNA, complete cds; alternatively spliced P

EST sequences (10 of 1057) [Show all sequences]

AA971388.1 Clone IMAGE:1583183 mixed 3' read A
AA971899.1 Clone IMAGE:1583185 mixed 3' read A
AA976159.1 Clone IMAGE:1556218 uncharacterized tissue 3' read A
AI000560.1 Clone IMAGE:1609961 mammary gland 3' read A
AI004925.1 Clone IMAGE:1632147 mammary gland 3' read A
AI033981.1 Clone IMAGE:1646672 parathyroid 3' read
AI034140.1 Clone IMAGE:1646875 parathyroid 3' read A
AI038837.1 Clone IMAGE:1659594 embryonic tissue 3' read A
AI041922.1 Clone IMAGE:1664604 skin 3' read
AI056303.1 Clone IMAGE:1674209 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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