3BQD: VAST+ Similar Structure Assemblies and Proteins

National Center for
Biotechnology Information

Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

Biological unit 1: dimeric

Source organism:

synthetic construct, ▼

Taxonomy

Taxonomy	Molecule
synthetic construct	B
Homo sapiens	A

Number of proteins:

2 (Glucocorticoid receptor, Nuclear receptor coact... ▼)

Protein molecule

	Glucocorticoid receptor
	Nuclear receptor coactivator 1

Number of chemicals:

1 (1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihy... ▼)

Chemical

Similar Structures (1362)

			PDB ID	Description	Taxonomy▲▼	Aligned Protein▲▼	RMSD▲▼	Aligned Residues▲▼	Sequence Identity▲▼
1	Expand row	Partial	1M2Z	Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif	Others	1	0.92Å	251	100%
2	Expand row	Partial	4P6X	Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain	Homo sapiens	1	1.17Å	251	97%
3	Expand row	Partial	1XJ7	Complex Androgen Receptor LBD and RAC3 peptide	Others	1	2.28Å	250	49%
4	Expand row	Partial	4P6W	Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain	Homo sapiens	1	1.57Å	249	97%
5	Expand row	Partial	1T65	Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation	Homo sapiens	1	1.92Å	249	49%
6	Expand row	Partial	3K22	Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide	Others	1	1.01Å	248	99%
7	Expand row	Partial	2A3I	Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and Coactivator Assembly by Mineralocorticoid Receptor	Others	1	1.53Å	248	57%
8	Expand row	Partial	4LTW	Ancestral Ketosteroid Receptor-Progesterone-Mifepristone Complex	Others	1	1.60Å	248	63%
9	Expand row	Partial	2PIR	Androgen receptor LBD with small molecule	Homo sapiens	1	1.82Å	248	50%
10	Expand row	Partial	3WFF	Mineralocorticoid receptor ligand-binding domain with compound 2b	Homo sapiens	1	2.04Å	248	56%

{"1":"Glucocorticoid receptor","2":"Nuclear receptor coactivator 1"}