2X2M: Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor

PDB ID: 2X2MDownload
MMDB ID: 79894
PDB Deposition Date: 2010/1/13
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2X2M: dimeric; determined by author and by software (PISA)
Molecular Components in 2X2M
Label Count Molecule
Proteins (2 molecules)
2
Proto-oncogene Tyrosine-protein Kinase Receptor RET
(Gene symbol: RET)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
5
FORMIC ACIDFORMIC ACID
2
2
(3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE(3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303