5FRO: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f)

PDB ID: 5FRODownload
MMDB ID: 136618
PDB Deposition Date: 2015/12/18
Updated in MMDB: 2016/06
Experimental Method:
x-ray diffraction
Resolution: 2.67  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5FRO: octameric; determined by author and by software (PISA)
Molecular Components in 5FRO
Label Count Molecule
Proteins (4 molecules)
4
PFV Integrase
Molecule annotation
Nucleotides(4 molecules)
2
5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp *tp*cp*gp*cp*a)-3'
Molecule annotation
2
5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp *ap*cp*a)-3'
Molecule annotation
Chemicals and Non-standard biopolymers (30 molecules)
1
2
ZINC IONZINC ION
2
6
MAGNESIUM IONMAGNESIUM ION
3
10
SULFATE IONSULFATE ION
4
2
4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide
5
10
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303