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3TTJ: Crystal Structure of Jnk3 Complexed With Cc-359, a JNK Inhibitor for the Prevention of Ischemia-reperfusion Injury
Bioorg. Med. Chem. Lett. (2012) 22 p.1427-1432» All references (1)
In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.