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| Reference: |
Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, Shi YMolecular mechanism of AHSP-mediated stabilization of alpha-hemoglobinCell v119, p.629-640Hemoglobin A (HbA), the oxygen delivery system in humans, comprises two alpha and two beta subunits. Free alpha-hemoglobin (alphaHb) is unstable, and its precipitation contributes to the pathophysiology of beta thalassemia. In erythrocytes, the alpha-hemoglobin stabilizing protein (AHSP) binds alphaHb and inhibits its precipitation....
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| Description: |
Crystal Structure Of Ahsp Bound To Fe(Ii) Alpha-Hemoglobin. |
| Deposition: |
2004/11/14   |
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| Author: |
Feng L, Gell DA, Zhou S, Gu L, Gow AJ, Weiss MJ, Mackay JP, Shi Y |
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| Taxonomy: |
Homo sapiens |
| Related Structure: |
VAST |
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Molecular components in the MMDB structure are listed below and may include macromolecular chains, 3D domains, protein classifications (domain families), and ligands, as available. Mouse over each icon for more information on the component.  | Ligand |
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CID444098 |
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1 occurrence |
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![Synonyms: oxygen,oxygen molecule,Molecular oxygen,Dioxygen,Hyperoxia,Oxygenium,Sauerstoff,Liquid oxygen,Pure oxygen,Oxygen (liquid),Oxygen, liquified,dioxidanediyl,dioxygene,oxigeno,oxygene,Disauerstoff,Oxygenium medicinale,Dioxygenyl ion,Oxygen-16,Oxygene [French],Oxigeno [Spanish],OXYGEN-MOLECULE,singlet molecular oxygen... -Click for PubChem compound information](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=977) |
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Oxygen |
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1 occurrence |
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![Synonyms: CID656923,C-HEGA-8, CYCLOHEXYLETHANOYL-N-HYDROXYETHYLGLUCOAMIDE,CHK,6-[(CYCLOHEXYLACETYL)(2-HYDROXYETHYL)AMINO]-6-DEOXY-D-XYLO-HEXITOL -Click for PubChem compound information](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=656923) |
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CID656923 |
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1 occurrence |
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Citing MMDB:
Wang Y, Addess KJ, Chen J, Geer LY, He J, He S, Lu S, Madej T, Marchler-Bauer A, Thiessen PA, Zhang N, Bryant SH.
"MMDB: annotating protein sequences with Entrez's 3D-structure database.",
Nucleic Acids Res. 2007 Jan; 35(Database issue): D298-300.
Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH.
"MMDB: Entrez's 3D-structure database", Nucleic Acids Res. 2003 Jan; 31(1): 474-7.
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