2FOS: Human Carbonic Anhydrase II Complexed With Two-prong Inhibitors

Citation:
Abstract
The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.
PDB ID: 2FOSDownload
MMDB ID: 38299
PDB Deposition Date: 2006/1/13
Updated in MMDB: 2012/10 
Experimental Method:
x-ray diffraction
Resolution: 1.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2FOS: monomeric; determined by author
Molecular Components in 2FOS
Label Count Molecule
Protein (1 molecule)
1
Carbonic Anhydrase II
Molecule annotation
Chemicals (5 molecules)
1
1
2
2
3
2
* Click molecule labels to explore molecular sequence information.

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