2F6W: Protein Tyrosine Phosphatase 1B With Sulfamic Acid Inhibitors

Citation:
Abstract
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
PDB ID: 2F6WDownload
MMDB ID: 36864
PDB Deposition Date: 2005/11/29
Updated in MMDB: 2007/10 
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2F6W: monomeric; determined by author
Molecular Components in 2F6W
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Phosphatase, Non-receptor Type 1
Molecule annotation
Chemicals (7 molecules)
1
1
2
5
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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