National Center for
2F6W: Protein Tyrosine Phosphatase 1B With Sulfamic Acid Inhibitors
Bioorg. Med. Chem. Lett. (2006) 16 p.1574-1578
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.