1XOG: N9 Tern Influenza Neuraminidase Complexed With a 2,5-disubstituted Tetrahydrofuran-5-carboxylic Acid

Citation:
Abstract
(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetrahydrofuran-5-carboxylic acid (9) and (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetrahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM.
PDB ID: 1XOGDownload
MMDB ID: 31454
PDB Deposition Date: 2004/10/6
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1XOG: monomeric; determined by author
Molecular Components in 1XOG
Label Count Molecule
Protein (1 molecule)
1
Neuraminidase
Molecule annotation
Chemicals (10 molecules)
1
4
2
1
3
4
4
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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