1UA7: Crystal Structure Analysis of Alpha-amylase From Bacillus Subtilis Complexed With Acarbose

Citation:
Abstract
The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.
PDB ID: 1UA7Download
MMDB ID: 27958
PDB Deposition Date: 2003/3/3
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.21  Å
Source Organism:
Similar Structures:
Biological Unit for 1UA7: monomeric; determined by author
Molecular Components in 1UA7
Label Count Molecule
Protein (1 molecule)
1
Alpha-amylase(Gene symbol: amyE)
Molecule annotation
Chemicals (9 molecules)
1
2
2
1
3
1
4
1
5
1
6
3
* Click molecule labels to explore molecular sequence information.

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