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1UA7: Crystal Structure Analysis of Alpha-amylase From Bacillus Subtilis Complexed With Acarbose
J. Bacteriol. (2003) 185 p.6981-6984» All references (4)
The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.