1CWL: Human Cyclophilin a Complexed With 4 4-hydroxy-meleu Cyclosporin

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
PDB ID: 1CWLDownload
MMDB ID: 73514
PDB Deposition Date: 1998/5/26
Updated in MMDB: 2011/08
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1CWL: dimeric; determined by software (PISA)
Molecular Components in 1CWL
Label Count Molecule
Protein (1 molecule)
Peptidyl-prolyl Cis-trans Isomerase a
Molecule annotation
Nucleotide(1 molecule)
Cyclosporin a
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB