Fragment-based Identification of Amides Derived From Trans-2-(pyridin- 3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (Nampt)
MMDB ID: 113763PDB ID: 4LVDhelp
PDB Deposition Date: 2013/7/26help
Updated in MMDB: 10/2013  help
Experimental Method:
X-Ray Diffraction help
Resolution: 1.75  Åhelp
Source Organism:
Similar Structures: help
Citation: help
Zheng X, Bair KW, Bauer P, Baumeister T, Bowman KK, Buckmelter AJ, Caligiuri M, Clodfelter KH, Feng Y, Han B, Ho YC, Kley N, Li H, Liang X, Liederer BM, Lin J, Ly J, O'Brien T, Oeh J, Oh A, Reynolds DJ, Sampath D, Sharma G, Skelton N, Smith CC, Tremayne J, Wang L, Wang W, Wang Z, Wu H, Wu J, Xiao Y, Yang G, Yuen PW, Zak M, Dragovich PS
Bioorg.Med.Chem.Lett. (2013) 23 p.5488
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Biological Unit: dimeric; determined by author, and by software (PISA)help
schmatic for structure MMDB ID=113763 biounit 1
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Molecular graphic for MMDB ID 113763 biounit 1
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Molecules and interactionshelp
Label Count Molecule Interactions
Proteins and interactions (2 molecules)
Nicotinamide Phosphoribosyltransferase
Show annotation
  • 1EB
  • Ethylene Glycol
  • Nicotinamide Phosphoribosyltransferase
  • Phosphate Ion
Chemicals and interactions (7 molecules)
 -Click for PubChem compound information. 4
  • Ethylene Glycol
  • Nicotinamide Phosphoribosyltransferase
 -Click for PubChem compound information. 2
  • Ethylene Glycol
  • Nicotinamide Phosphoribosyltransferase
 -Click for PubChem compound information. 1
  • 1EB
  • Nicotinamide Phosphoribosyltransferase
  • Phosphate Ion
* Click molecule labels to explore molecular sequence information.

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