Crystal Structure of Human Cdk8/cycc in Complex With Compound 1 (N-[3- Tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl- 1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine- 1-carboxamide)
MMDB ID: 109592PDB ID: 4F6Whelp
PDB Deposition Date: 2012/5/15help
Updated in MMDB: 05/2013help
Experimental Method:
X-Ray Diffraction help
Resolution: 2.39  Åhelp
Source Organism:
Similar Structures: help
Citation: help
The discovery of slowness in terms of compound binding kinetics: a structure-kinetic-relationship study on cdk8/cycc.
Schneider EV, Boettcher J, Huber R, Maskos K, Neumann L
No recorded citation in PubMed
  • help
Biological Unit: dimeric; determined by author, and by software (PISA)help
Interactions?
schmatic for structure MMDB ID=109592 biounit 1
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Molecular graphic for MMDB ID 109592 biounit 1
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ProteinChemical
Molecules and interactionshelp
Label Count Molecule Interactions
Proteins and interactions (2 molecules)
1
Cyclin-dependent Kinase 8
Show annotation
  • 0SS
  • Cyclin-c
  • Dimethyl Sulfoxide
  • Ethylene Glycol
  • Formic Acid
1
Cyclin-c
Show annotation
  • Cyclin-dependent Kinase 8
  • Ethylene Glycol
  • Formic Acid
Chemicals and interactions (16 molecules)
 -Click for PubChem compound information. 1
  • Cyclin-dependent Kinase 8
  • Dimethyl Sulfoxide
 -Click for PubChem compound information. 1
  • 0SS
  • Cyclin-dependent Kinase 8
 -Click for PubChem compound information. 9
  • Cyclin-c
  • Cyclin-dependent Kinase 8
  • Formic Acid
 -Click for PubChem compound information. 5
  • Cyclin-c
  • Cyclin-dependent Kinase 8
  • Ethylene Glycol
* Click molecule labels to explore molecular sequence information.

Citing MMDB
Madej T, Addess KJ, Fong JH, Geer LY, Geer RC, Lanczycki CJ, Liu C, Lu S, Marchler-Bauer A, Panchenko AR, Chen J, Thiessen PA, Wang Y, Zhang D, Bryant SH. "MMDB: 3D structures and macromolecular interactions." Nucleic Acids Res. 2012 Jan; 40(Database issue):D461-4
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