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| Reference: |
Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit REStructure of a BRCA1-BARD1 heterodimeric RING-RING complexNat. Struct. Biol. v8, p.833-837The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1....
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| Description: |
Solution Structure Of The Brca1BARD1 RING-Domain Heterodimer. |
| Deposition: |
2001/7/17   |
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| Author: |
Brzovic PS, Rajagopal P, Hoyt DW, King M-C, Klevit RE |
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| Taxonomy: |
Homo sapiens |
| Related Structure: |
VAST |
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Molecular components in the MMDB structure are listed below and may include macromolecular chains, 3D domains, protein classifications (domain families), and ligands, as available. Mouse over each icon for more information on the component. 
Citing MMDB:
Wang Y, Addess KJ, Chen J, Geer LY, He J, He S, Lu S, Madej T, Marchler-Bauer A, Thiessen PA, Zhang N, Bryant SH.
"MMDB: annotating protein sequences with Entrez's 3D-structure database.",
Nucleic Acids Res. 2007 Jan; 35(Database issue): D298-300.
Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH.
"MMDB: Entrez's 3D-structure database", Nucleic Acids Res. 2003 Jan; 31(1): 474-7.
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