Crystal Structure of the Prototype Foamy Virus (Pfv) S217h Mutant Intasome in Complex With Magnesium and Dolutegravir (Sgsk1349572)
MMDB ID: 91580PDB ID: 3S3Nhelp
PDB Deposition Date: 2011/5/18help
Updated in MMDB: 10/2011  help
Experimental Method:
X-Ray Diffraction help
Resolution: 2.49  Åhelp
Source Organism:
synthetic construct ▼help
Similar Structures: help
Citation: help
Hare S, Smith SJ, Metifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov P
Mol.Pharmacol. (2011) 80 p.565
  • help
Biological Unit: octameric; determined by author, and by software (PISA)help
Interactions?
schmatic for structure MMDB ID=91580 biounit 1
Molecular Graphic ?
Molecular graphic for MMDB ID 91580 biounit 1
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ProteinNucleotideChemical
Molecules and interactionshelp
Label Count Molecule Interactions
Proteins and interactions (4 molecules)
4
PFV Integrase
Show annotation
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Ammonium Ion
  • Dolutegravir
  • Glycerin
  • Magnesium Ion
  • PFV Integrase
  • Sulfate Ion
  • Zinc Ion
Nucleotides and interactions (4 molecules)
2
5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
*cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Ammonium Ion
  • Dolutegravir
  • PFV Integrase
  • Sulfate Ion
2
5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
*cp*a)-17 3'
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • Dolutegravir
  • PFV Integrase
Chemicals and interactions (24 molecules)
 -Click for PubChem compound information. 2
  • PFV Integrase
 -Click for PubChem compound information. 6
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • PFV Integrase
 -Click for PubChem compound information. 8
  • PFV Integrase
 -Click for PubChem compound information. 2
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • PFV Integrase
 -Click for PubChem compound information. 4
  • Dolutegravir
  • Magnesium Ion
  • PFV Integrase
 -Click for PubChem compound information. 2
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Magnesium Ion
  • PFV Integrase
* Click molecule labels to explore molecular sequence information.

Citing MMDB
Madej T, Addess KJ, Fong JH, Geer LY, Geer RC, Lanczycki CJ, Liu C, Lu S, Marchler-Bauer A, Panchenko AR, Chen J, Thiessen PA, Wang Y, Zhang D, Bryant SH. "MMDB: 3D structures and macromolecular interactions." Nucleic Acids Res. 2012 Jan; 40(Database issue):D461-4
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