Crystal Structure of the Prototype Foamy Virus (Pfv) Intasome in Complex With Magnesium and the Insti Pica
MMDB ID: 86314PDB ID: 3OYChelp
PDB Deposition Date: 2010/9/23help
Updated in MMDB: 05/2011  ▼help
Experimental Method:
X-Ray Diffraction help
Resolution: 2.66  Åhelp
Source Organism:
synthetic construct ▼help
Similar Structures: help
Citation: help
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P
Proc.Natl.Acad.Sci.Usa (2010) 107 p.20057
  • help
Biological Unit: octameric; determined by author, and by software (PISA)help
Interactions?
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ProteinNucleotideChemical
Molecules and interactionshelp
Label Count Molecule Interactions
Proteins and interactions (4 molecules)
4
PFV Integrase
Show annotation ▼
  • Ammonium Ion
  • DNA (5'-15 D(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*
    tp*gp*ap*cp*a)-3')
  • DNA (5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*t
    p*tp*tp*cp*gp*cp*a)-3')
  • Glycerin
  • Magnesium Ion
  • PACA
  • PFV Integrase
  • Sulfate Ion
  • Zinc Ion
Nucleotides and interactions (4 molecules)
2
DNA (5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*t
p*tp*tp*cp*gp*cp*a)-3')
  • DNA (5'-15 D(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*
    tp*gp*ap*cp*a)-3')
  • PACA
  • PFV Integrase
2
DNA (5'-15 D(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*
tp*gp*ap*cp*a)-3')
  • DNA (5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*t
    p*tp*tp*cp*gp*cp*a)-3')
  • Magnesium Ion
  • PACA
  • PFV Integrase
Chemicals and interactions (22 molecules)
-Click for PubChem compound information.
4
  • PFV Integrase
-Click for PubChem compound information.
2
  • DNA (5'-15 D(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*
    tp*gp*ap*cp*a)-3')
  • DNA (5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*t
    p*tp*tp*cp*gp*cp*a)-3')
  • Magnesium Ion
  • PFV Integrase
 
2
Zn++ (Zinc Ion)
  • PFV Integrase
 
8
  • PFV Integrase
 
2
  • PFV Integrase
 
4
Mg++ (Magnesium Ion)
  • DNA (5'-15 D(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*
    tp*gp*ap*cp*a)-3')
  • Magnesium Ion
  • PACA
  • PFV Integrase
* Click molecule labels to explore molecular sequence information.
* The interaction graph may not show all instances of molecules listed in the table.
Citing MMDB
Madej T, Addess KJ, Fong JH, Geer LY, Geer RC, Lanczycki CJ, Liu C, Lu S, Marchler-Bauer A, Panchenko AR, Chen J, Thiessen PA, Wang Y, Zhang D, Bryant SH. "MMDB: 3D structures and macromolecular interactions." Nucleic Acids Res. 2012 Jan; 40(Database issue):D461-4
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