3L2W: Crystal Structure of the Prototype Foamy Virus (Pfv) Intasome in Complex With Manganese and Gs9137 (Elvitegravir)

PDB ID: 3L2WDownload
MMDB ID: 80010
PDB Deposition Date: 2009/12/15
Updated in MMDB: 05/2011 
Experimental Method:
X-Ray Diffraction
Resolution: 3.2  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit: octameric; determined by author, and by software (PISA)
Molecules and interactions
Label Count Molecule Interactions
Proteins and interactions (4 molecules)
4
Integrase
Show annotation
  • 5'-15 D(*tp*ap*cp*ap*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp
    *ap*cp*a)-3'
  • 5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
    tp*tp*gp*tp*a)9 -3'
  • Ammonium Ion
  • Elvitegravir, Gs9137, Jtk 303
  • Glycerol
  • Integrase
  • Manganese (ii) Ion
  • Zinc Ion
Nucleotides and interactions (4 molecules)
2
5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
tp*tp*gp*tp*a)9 -3'
  • 5'-15 D(*tp*ap*cp*ap*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp
    *ap*cp*a)-3'
  • Ammonium Ion
  • Elvitegravir, Gs9137, Jtk 303
  • Glycerol
  • Integrase
2
5'-15 D(*tp*ap*cp*ap*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp
*ap*cp*a)-3'
  • 5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
    tp*tp*gp*tp*a)9 -3'
  • Elvitegravir, Gs9137, Jtk 303
  • Integrase
Chemicals and interactions (20 molecules)
 -Click for PubChem compound information. 2
  • Integrase
 -Click for PubChem compound information. 6
  • Elvitegravir, Gs9137, Jtk 303
  • Integrase
 -Click for PubChem compound information. 2
  • 5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
    tp*tp*gp*tp*a)9 -3'
  • Integrase
 -Click for PubChem compound information. 2
  • 5'-15 D(*tp*ap*cp*ap*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp
    *ap*cp*a)-3'
  • 5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
    tp*tp*gp*tp*a)9 -3'
  • Integrase
  • Manganese (ii) Ion
 -Click for PubChem compound information. 8
  • 5'-8 D(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*
    tp*tp*gp*tp*a)9 -3'
  • Integrase
* Click molecule labels to explore molecular sequence information.

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