5JUZ: Crystal structure of human FPPS in complex with an allosteric inhibitor CL-06-057

PDB ID: 5JUZDownload
MMDB ID: 148085
PDB Deposition Date: 2016/5/10
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 5JUZ: dimeric; determined by author and by software (PISA)
Molecular Components in 5JUZ
Label Count Molecule
Proteins (2 molecules)
2
Farnesyl Pyrophosphate Synthase
(Gene symbol: FDPS)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
4
CHLORIDE IONCHLORIDE ION
2
2
[(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid[(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303