3I3S: Crystal Structure of H-ras With Thr50 Replaced by Isoleucine

Citation:
Abstract
Noonan syndrome, a developmental disorder characterized by congenital heart defects, reduced growth, facial dysmorphism and variable cognitive deficits, is caused by constitutional dysregulation of the RAS-MAPK signaling pathway. Here we report that germline NRAS mutations conferring enhanced stimulus-dependent MAPK activation account for some cases of this disorder. These findings provide evidence for an obligate dependency on proper NRAS function in human development and growth.
PDB ID: 3I3SDownload
MMDB ID: 78909
PDB Deposition Date: 2009/6/30
Updated in MMDB: 2009/12 
Experimental Method:
x-ray diffraction
Resolution: 1.36  Å
Source Organism:
Similar Structures:
Biological Unit for 3I3S: monomeric; determined by author
Molecular Components in 3I3S
Label Count Molecule
Protein (1 molecule)
1
Gtpase Hras
(Gene: HRAS)
Molecule annotation
Chemicals (5 molecules)
1
1
2
3
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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