1UVQ: Crystal Structure of Hla-dq0602 in Complex With a Hypocretin Peptide

Citation:
Abstract
The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the specificity of the P9 pocket, which implies that presentation of an expanded peptide repertoire is critical for dominant protection against type 1 diabetes. In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role.
PDB ID: 1UVQDownload
MMDB ID: 105336
PDB Deposition Date: 2004/1/22
Updated in MMDB: 2012/11 
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit: trimeric; determined by author, and by software (PISA)
Molecular Components
Label Count Molecule
Proteins (3 molecules)
1
HLA Class II Histocompatibility Antigen
Molecule annotation
1
HLA Class II Histocompatibility Antigen
Molecule annotation
1
Orexin
Molecule annotation
Chemicals (8 molecules)
1
4
2
1
3
1
4
1
5
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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