|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
3-451 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 760.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 3 PPAGTPTYPPPDGGWGWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRY 82
Cdd:TIGR00892 2 PPALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 83 GSRPVVITGGLLCCLGMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAP 162
Cdd:TIGR00892 82 GCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 163 FNQYLFNTFGWKGSFLILGGILLNSCVAGSLMRPVGPKQT-NKAKNKIGIKADeAEAKKSHKKSLSEKINKYLDFSLFKH 241
Cdd:TIGR00892 162 LNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRvSKSKSKEGLPPD-GSTKKLSKKSTAEKINRFLDFSLFTH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 242 RGFLIYLSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFT 321
Cdd:TIGR00892 241 RGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 322 GVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYK 401
Cdd:TIGR00892 321 GLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYK 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2124478937 402 YMYIACGAIVFLSSVWLLIGNAINYRLLAKEKKLAEAEKKIHKPESTESE 451
Cdd:TIGR00892 401 YIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAEGD 450
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
18-422 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 637.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPVGPkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17427 203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17427 283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362
|
....*
gi 2124478937 418 LLIGN 422
Cdd:cd17427 363 LFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
18-421 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 540.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPVGPKqtnkaknkigikadeaeakkshkkslsekinKYLDFSLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK-------------------------------PFLDLTLFTHRGFLLYLSGNVIMFFG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17426 210 LFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17426 290 CIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIY 369
|
....
gi 2124478937 418 LLIG 421
Cdd:cd17426 370 LFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
18-422 |
2.06e-154 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 443.40 E-value: 2.06e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPvgpkqtnkaknkigikadeaeakkshkkslsekinkyLDFSLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-------------------------------------LDFSVFRDRGFVIYTIAKFIMVLG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17430 204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17430 284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363
|
....*
gi 2124478937 418 LLIGN 422
Cdd:cd17430 364 LALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-420 |
7.96e-127 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 372.66 E-value: 7.96e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------------LLKDPTFVLLALGVSFAMLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsrFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17352 199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
...
gi 2124478937 418 LLI 420
Cdd:cd17352 357 LFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
5.15e-113 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 337.90 E-value: 5.15e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-----------------------------------------FCSNTRYQIYTLGVTWMVLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17425 200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359
|
...
gi 2124478937 418 LLI 420
Cdd:cd17425 360 MGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
18-419 |
2.56e-93 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 287.75 E-value: 2.56e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPvgpkqtnkaknkIGIKADEAEAKKShkkslsekINKYLDFSLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17423 161 LLLSALSLHLVPCGALLRP------------LALPGDPPAPPRS--------LSAAFGLSLLTHRAFLRYALATTLINTG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPriQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17423 221 YFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17423 299 LALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLI 378
|
..
gi 2124478937 418 LL 419
Cdd:cd17423 379 LL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-418 |
4.86e-83 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 260.84 E-value: 4.86e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17422 161 LVVGALQLNIVVCGALLR------------------------------------------VLKEPGFICYALFGLFATLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRpRIQYFFSFAIMFtGVCHLLCPLAEDYTSL 337
Cdd:cd17422 199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLM--DLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSS 415
Cdd:cd17422 277 LVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
...
gi 2124478937 416 VWL 418
Cdd:cd17422 357 VFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-418 |
2.50e-63 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 209.67 E-value: 2.50e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldFSLFKhrGFLIYLSGNVIMFLG 257
Cdd:cd17424 161 LILGGFVLNLCVCGALMR----------------------------------------FLLMP--DFLVLAVSVLFLAYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17424 199 CSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17424 279 VPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLL 358
|
.
gi 2124478937 418 L 418
Cdd:cd17424 359 L 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
5.76e-55 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 187.72 E-value: 5.76e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLStLAPFNQYLFNTFGWKGSF 177
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPVgpkqtnkaknkigikadeaeakkshkkslsekinkylDFSLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI-------------------------------------DFSLLKDPFFCIYTWSFVFSQLA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRpRIQYFFSFAIMfTGVCHLLCPLAEDYTSL 337
Cdd:cd17421 203 YFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK-KYHYHKAYLIL-CGVTNLLAPLATTYPLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17421 281 MTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVS 360
|
...
gi 2124478937 418 LLI 420
Cdd:cd17421 361 FFL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-420 |
1.07e-39 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 147.33 E-value: 1.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLG 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 99 MVSASFSTNvVELYLTVGFIGGIGLAFNLQPALTIIGKYFYK-KRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLnscVAGSLMRpvgpkqtnkaknkIGIKADEAEAKKSHKKSLSEKinkyldFSLFKHRGFLIYLSGNVIMFLG 257
Cdd:COG2223 163 LILGILLL---VVAVLAW-------------LFLRDPPAGAAAAAKASLRDQ------LEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDK-GIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqYFFSFAIMFTGVChLLCPLAEDYTS 336
Cdd:COG2223 221 FIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRV-LLIVFALMALGLL-LLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 337 LVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSV 416
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
....
gi 2124478937 417 WLLI 420
Cdd:COG2223 378 LTLL 381
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
1.19e-38 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 143.82 E-value: 1.19e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR------------------------------------------LFTNKVFVAFIFWALFAYCS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAF-LLSIMAFVDMFARPSVGLIANSRFIrpRIQYFFSFAIMFTGVCHLLCPLAEDYTS 336
Cdd:cd17429 199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCILILPLMHTYTG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 337 LVLYA--IFFGLGFGSVSSVLFEtlmDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLS 414
Cdd:cd17429 277 LAIVCalIGFSSGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVG 353
|
....*.
gi 2124478937 415 SVWLLI 420
Cdd:cd17429 354 IICLLL 359
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
18-418 |
4.26e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 143.44 E-value: 4.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNA-----SYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGG 92
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 93 LLCCLGMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFG 172
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 173 WKGSFLILGGILLNSCVAGSLMRPVGPkqtnkaknkigikADEAEAKKSHKKSLSEKIN----KYLDFSLFKHRGFLIYL 248
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHP-------------SPEDPKSKPGRRTLHSRINlflrKIFNVEIFKRKRYVIWA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 249 SGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIqYFFSFAIMFTGVCHLLC 328
Cdd:cd17420 228 LGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 329 PLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACG 408
Cdd:cd17420 307 PLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAG 386
|
410
....*....|
gi 2124478937 409 AIVFLSSVWL 418
Cdd:cd17420 387 VPPLIGSSLL 396
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-420 |
1.99e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 137.69 E-value: 1.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 15 GGWGWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLL 94
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 95 CCLGMVSASFSTNVVELYLTVgFIGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGW 173
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 174 KGSFLILGGIllnsCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfslfkhrgFLIYLSGNVI 253
Cdd:COG2271 164 RAAFLILGLP----GLLLALLR------------------------------------------------FWLLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 254 MFLGFFAPIIFLAPYAKD-KGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMftGVCHLLCPLAE 332
Cdd:COG2271 192 VYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA--ALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 333 DYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVF 412
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALAL 348
|
....*...
gi 2124478937 413 LSSVWLLI 420
Cdd:COG2271 349 LAALLALL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-419 |
1.02e-34 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 133.55 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPA-LTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGS 176
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 177 FLILGGILLNSCVAGSLMRPVGPKQTNKAKNKIGIKADEAEAKKshkkslsekinkyldfSLFKHRGFLIYLSGNVIMFL 256
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLK----------------EALRSASFWLLALAFFLCGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 257 GFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyffSFAIMFTGVCHLLCPLA--EDY 334
Cdd:cd17355 225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-RYSPRRL----LAASYALRALGLALLLLlpFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 335 TSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLS 414
Cdd:cd17355 300 LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....*
gi 2124478937 415 SVWLL 419
Cdd:cd17355 380 ALLVL 384
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
18-424 |
1.91e-34 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 132.99 E-value: 1.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSE-----IAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGG 92
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 93 LLCCLGMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFG 172
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 173 WKGSFLILGGILLNSCVAGSLMRPVGPKQTNKAKNKigikadeaeakkshKKSLSEKINKYLDFSLFKHRGFLIYLSGNV 252
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK--------------RKFKCPPLKKIFNFNIWKSTGYRIWAFGIP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 253 IMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsrfIRPRIQ--YFFSFAIMFTGVCHLLCPL 330
Cdd:cd17464 227 AALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVAD---YIPGVKkvYLQVSSFFFIGLMSMMIPL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 331 AEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYiacgai 410
Cdd:cd17464 304 CHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAF------ 377
|
410
....*....|....
gi 2124478937 411 vFLSSVWLLIGNAI 424
Cdd:cd17464 378 -YLAGVPPIIGGII 390
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-413 |
1.80e-33 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 130.38 E-value: 1.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 1 MPPPAGTPTYPPPDGGWgWVVVGAAFISIGFSYAFPkAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVN 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRW-LLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 81 RYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTVGFIG-GIGLAFNLQPALtiIGKYFYKKRPMANGLAMAGSPVFLST 159
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYTAAMGLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 160 LAPFNQYLFNTFGWKGSFLILGGILLNSCVAGSLMRPVGPKQTNKAKNKIGIKadeaeakkshkkslsekinkyldfSLF 239
Cdd:COG2807 157 AAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR------------------------SLW 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 240 KHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIAnSRFIRPRIQYFFSFAIM 319
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA-DRLGDRRPLLLLLGLLG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 320 FTGVCHLLcpLAEDyTSLVLYAIFFGLGFGSVSSVLFETLMDLVG-AQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETG 398
Cdd:COG2807 292 LAGLLGLL--LAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
|
410
....*....|....*
gi 2124478937 399 QYKYMYIACGAIVFL 413
Cdd:COG2807 369 SWTAALLLLAALAVL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-387 |
3.14e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 125.99 E-value: 3.14e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 20 VVVGAAFISIGFSYAFPkaitVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGM 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 100 VSASFSTNVVELYLtVGFIGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSFL 178
Cdd:pfam07690 77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 179 ILGGILLNSCVAGSLMRPVGPKQTNKAKNKIGIKADEAeakkshkkslsekinkyldFSLFKHRGFLIYLSGNVIMFLGF 258
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-------------------WKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 259 FAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSLV 338
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2124478937 339 LYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGP 387
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
4.80e-32 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 125.70 E-value: 4.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRpvgpkqtnkaknkigikadeaeakkshkkslsekinkyldfsLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17428 161 LIVGALALNLLACGSLMR------------------------------------------LFKNRVFSALFIAILLFDIG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAF-LLSIMAFVDMFARPSVGLIANSRFIRPriQYFFSFAIMFTGVCHLLCPLAEDYTS 336
Cdd:cd17428 199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 337 LVLYAIFFGLGFGSVSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSV 416
Cdd:cd17428 277 LAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 355
|
....
gi 2124478937 417 WLLI 420
Cdd:cd17428 356 LLLL 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-378 |
1.35e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.23 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 12 PPDGGWGWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITG 91
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 92 GLLCCLGMVSASFSTNVVELYLtVGFIGGIGLAFNLQPALTIIGKYF-YKKRPMANGLAMAGSPVFLSTLAPFNQYLFNT 170
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 171 FGWKGSFLILGGILLNSCVAGSLMrpvgpkqtnkaknkigIKADEAEAKKSHKKSLSEkinkyldfsLFKHRGFLIYLSG 250
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL----------------LPESRPAARARLRGSLRE---------LLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 251 NVIMFLGFFAPIIFLAPYAKDK-GIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMFTGVCHLLCP 329
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRL---LLIGLLLLALGLLLLA 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2124478937 330 LAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIV 378
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-420 |
3.30e-27 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 112.70 E-value: 3.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFI---SIGFSYAFpkaiTVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLC 95
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 96 CLGMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAG---SPVFLStlaPFNQYLFNTFG 172
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGfglGSLIFS---PLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 173 WKGSFLILGGI-LLNSCVAGSLMRPVGPKQTNKAKNKIGIKADEAEAKKSHKKSLSEKinkyldfslfkhRGFLIYLSgn 251
Cdd:cd17353 156 VPTTFLILGIIfLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTP------------TFWLLWLM-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 252 viMFLGFFAPIIF---LAPYAKDK-GIDEYSAAFLLSIMAFVDMFARPSVGLIanSRFIRPRIQYFFSFAIMftGVCHLL 327
Cdd:cd17353 222 --FFLNATAGLMLigqAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWL--SDKIGRKNTLSIAFLIQ--GVAMFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 328 CPLA-EDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGkLVDETGQYKYMYIA 406
Cdd:cd17353 296 LPFIgSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFII 374
|
410
....*....|....
gi 2124478937 407 CGAIVFLSSVWLLI 420
Cdd:cd17353 375 AAALSLVALALALL 388
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-421 |
8.43e-27 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 111.35 E-value: 8.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGGILLNSCVAGSLMRPVGPKQTNKAKNKIGIKADEaeakkshkkslSEKINKYLDFSLFkhrgFLIYLSgnviMFLG 257
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQT-----------MGEIFRDKVFWIL----FIAIFL----VLIG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYS-AAFLLSIMAFVDMFARPSVGLIANsRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTS 336
Cdd:cd17314 222 GFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCAFLFLLKMTPVG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 337 LVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSV 416
Cdd:cd17314 301 LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
....*
gi 2124478937 417 WLLIG 421
Cdd:cd17314 381 ILLAV 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
38-416 |
8.18e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 8.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 38 AITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTvGF 117
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG-RF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 118 IGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLF--NTFGWKGSFLILGGILLNSCVAGSLM 194
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 195 RPvgpkqtnkaknkigikaDEAEAKKSHKKSLSEKINKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDKG- 273
Cdd:cd06174 173 VP-----------------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 274 IDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVchlLCPLAEDYTSLVLYAIFFGLGFGSVSS 353
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA---LLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2124478937 354 VLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSV 416
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-421 |
7.87e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.88 E-value: 7.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 20 VVVGAAFISIGFSYAFPkAITVFFKEiqqiFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGM 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIP-ILPLYAES----LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 100 VSASFSTNVVELYLTVgFIGGIGLAFNLQPALTIIGKYF-YKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSFL 178
Cdd:cd17325 76 LLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 179 ILGGILLNSCVAGSLMRPVGPKQTNKAKNKIGIKADEAeakkshkkslsekinkyldFSLFKHRGFLIYLSGNVIMFLGF 258
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGL-------------------RLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 259 FAPIIFLAPYAKDK-GIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17325 216 GALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPL---ILIGLLLSAVALLLLPLATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSVW 417
Cdd:cd17325 292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVL 370
|
....
gi 2124478937 418 LLIG 421
Cdd:cd17325 371 FLLL 374
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
18-400 |
5.65e-21 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 94.09 E-value: 5.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQ-----QIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGG 92
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLneqedQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 93 LLCCLGMVSASFSTNVVELYLTVGFIGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFG 172
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 173 WKGSFLILGGILLnscvagslmrpvgpkqtnkaknkigikadeaeakkshkkslsEKINKYLDFSLFKHRGFLIYLSGNV 252
Cdd:cd17465 161 LAHTFQVLSLFMF------------------------------------------IQIFLSLTYKVFRRKTYRIWAFGIA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 253 IMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSrFIRPRIQYFFSFAIMFTGVCHLLCPLAE 332
Cdd:cd17465 199 TAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDL-IPGLKKIYLQVASFLLLGIMSMMIPLCQ 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2124478937 333 DYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQY 400
Cdd:cd17465 278 VFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSY 345
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-419 |
3.98e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 82.64 E-value: 3.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 60 ISSIMLAVMYAGgPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVeLYLTVGFIGGIGLAFNLQPALTIIGKYFY 139
Cdd:cd17489 37 VGLFTLAALLAR-PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 140 KKRpMANGLAMAGSPVFLSTL--APFNQYLFNTFGWKGSFLILGGILLNSCVAGSLMRPVGPKqtnkaknkigiKADEAE 217
Cdd:cd17489 115 PSR-RGEGIGYYGLATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV-----------AAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 218 AKKSHKKSLSEKinkyldfslfkhRGFLIYLSGNViMFLGFFAPIIFLAPYAKDKGIDeySAAFLLSIMAFVDMFARPSV 297
Cdd:cd17489 183 AGTRAFRRLVEK------------KVLPPALILFL-ASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 298 GLIANsrFIRPRIQYFFSFAIMFTGVCHLLcpLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTI 377
Cdd:cd17489 248 GKLSD--RKGPKTVIIPGLLLLALGLLLLS--FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFI 323
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2124478937 378 VECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSVWLL 419
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-418 |
1.17e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.44 E-value: 1.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 20 VVVGAAFISIGFSYAfpkAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGM 99
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 100 VSASFSTNVVeLYLTVGFIGGIGLAF---NLQPALTIIGKYFYKKR-PMA---NGLAMAGSPVFLSTLAPFNqylfNTFG 172
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLhafFSLGALLGPLLGGLLILLG----LSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 173 WKGSFLILGGILLnsCVAGSLMRPVGPKqtnkaknkigIKADEAEAKKSHKKSlsekinkyldFSLFKHRGFLIYLsgnV 252
Cdd:COG0738 163 WHLPYLILAVLLL--LLALLFLRSKLPE----------IEEEEEEAAGSAASL----------KSLLKNPRLLLGG---L 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 253 IMFLGFFA---PIIFLAPYAKD-KGIDEYSAAFLLSIMAFVDMFARPSVGLIAnsRFIRPRIQYFFSFAIMFTGVchLLC 328
Cdd:COG0738 218 AIFLYVGAegaIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLL--KRFGPVRLLRLSALLAAVGL--LLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 329 PLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRfSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYI--A 406
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVplV 372
|
410
....*....|..
gi 2124478937 407 CGAIVFLSSVWL 418
Cdd:COG0738 373 CYLLILLLALAL 384
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-416 |
2.26e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 80.69 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 43 FKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELyLTVGFIGGIG 122
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 123 LAFNLQPALTIIGKYF-YKKRP-------MANGLAMAGSPVFLSTLApfnqylfnTFGWKGSFLILGGILLnscVAGSLM 194
Cdd:cd17474 101 AAGLGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIP---VAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 195 RPVGPKQTNKAKNKIGIKADEAeakkshkkslsekinkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDK-G 273
Cdd:cd17474 170 LFLLPEPKEKAKSSSATKLRDL-------------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 274 IDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIqYFFSFAIMftGVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSS 353
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI-LVIGLLLY--ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2124478937 354 VLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSV 416
Cdd:cd17474 308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAV 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-420 |
1.39e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.00 E-value: 1.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 72 GPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNvveLYLTVG--FIGGIGLAFNLQPALTIIGKYF---YKKRPMA- 145
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS---LYALLAsrALLGIGVAGIMTLATALIGDYFegeERAKMLGl 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 146 NGLAMAGSPVFLSTLAPFnqylFNTFGWKGSFLI-LGGILLNSCVAGSLMRPVGPKQTNKAKNKigikadeAEAKKSHKK 224
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLLFLPEPARKSKSAASPGA-------ATAAALPWK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 225 SLsekinkyldfslfkhrgFLIYLSGNVIMFLgFFAPIIFLAPYAKDKGI-DEYSAAFLLSIMAFVDMFARPSVGLIanS 303
Cdd:cd17473 198 RV-----------------LPIYFLAFLAMLL-FYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRL--K 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 304 RFIRPRIQYFFSFAIMFTGvcHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVeccpV 383
Cdd:cd17473 258 RRLGKRRLLAIGFALMALG--FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA----F 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2124478937 384 LLG----PPLAGKLVDETGQYKYMYIACGAIVFLSSVWLLI 420
Cdd:cd17473 332 FLGqflsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-419 |
1.07e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 45 EIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNvVELYLTVGFIGGIGLA 124
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 125 FNLQPALTIIGKYF-YKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSFLILGGILLnscVAGSLMRPVGPKQTN 203
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL---LAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 204 KAKNKIGIKADEaeakkshkkslsekinkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDK-GIDEYSAAFL 282
Cdd:cd17324 180 KKPGSLGLLSSL--------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 283 LSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMFTGVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDL 362
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLAD-RGGRRAL---LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2124478937 363 VGAQRfSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSVWLL 419
Cdd:cd17324 316 APEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
237-420 |
1.79e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.54 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 237 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSF 316
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGRRRV---LLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 317 AIMFTGVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDE 396
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....
gi 2124478937 397 TGqYKYMYIACGAIVFLSSVWLLI 420
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-419 |
2.00e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 71.50 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 46 IQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELyLTVGFIGGIGLAf 125
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL-LVLLFLVGAGYG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 126 NLQPALT--IIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSFLILGGILLNSCVAGSLM--RPVGPKQ 201
Cdd:cd17475 100 SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyrEPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 202 tnkaknkigikadEAEAKKSHKKSLSEkinkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDK-GIDEYSAA 280
Cdd:cd17475 180 -------------ATESASTLLRSLKE---------VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 281 FLLSIMAFVDMFARPSVGLIANSRFIRPRIQY--FFSFAIMFTGVCHLLCPLAEDYTSLVLYAIFFGL---GFGSVSSVL 355
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVlvITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLfaiGWNGLYLTL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2124478937 356 fetLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVWLL 419
Cdd:cd17475 318 ---VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-185 |
1.12e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.60 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 7 TPTYPPPDGGWGWVVVGAAFISIGFSYAfpkAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRP 86
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 87 VVITGGLLCCLGMVSASFSTNVVELYLTVgFIGGIGLAFNLQPALTIIGKYF-YKKRPMANGLAMAGSPVFLSTLAPFNQ 165
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180
....*....|....*....|
gi 2124478937 166 YLFNTFGWKGSFLILGGILL 185
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGL 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
248-416 |
1.14e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.00 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 248 LSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSrfIRPRIQYFFSFAIMftGVCHLL 327
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 328 CPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIAC 407
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
....*....
gi 2124478937 408 GAIVFLSSV 416
Cdd:cd17489 157 AVLALLALL 165
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-378 |
3.66e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 61.44 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 38 AITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELyLTVGF 117
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 118 IGGIGLAFnLQP-ALTIIGKYfYKKRPMANGLAMAGSPVFLS-TLAP-FNQYLFNTFGWKGSFLILGGILLNSCVAGSLm 194
Cdd:cd17503 93 LQGFGGGV-LIPlAQTILLRI-YPPEKRGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYINLPIGILALLLAPL- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 195 rpvgpkqtnkaknkigikadeaeakkshkkslsekinkyLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-KG 273
Cdd:cd17503 170 ---------------------------------------LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 274 IDEYSAAFLLSIMAFVDMFARPSVGLIANSrfIRPRIQYFFSFAIMFTGvCHLLCPLAED--YTSLVLYAIFFGLGFGSV 351
Cdd:cd17503 211 YSAFESGLVLAPGGLASAILSPLVGRLLDK--FGPRLLLLAGLLLLALG-TLLLAFLTPDtsLWLIILPLFIRGLGMGLV 287
|
330 340
....*....|....*....|....*..
gi 2124478937 352 SSVLFETLMDLVGAQRFSSAVGLVTIV 378
Cdd:cd17503 288 FMPLNTLALNSLPPEQIGDATALFNTI 314
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-420 |
4.13e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLG 98
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 99 MVSASFSTNVVELYLtVGFIGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 178 LILGgillnscVAGSLMRPVgpkqtnkaknkigikadeaeakkshkkslsekinkyldfSLFKHRGFLIYLSGNVIMFLG 257
Cdd:cd17319 161 IIEG-------LLGLLLAVL---------------------------------------WWFYLRQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 258 FFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSL 337
Cdd:cd17319 195 LYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 338 VLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSVW 417
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
...
gi 2124478937 418 LLI 420
Cdd:cd17319 355 VLL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-444 |
8.50e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.69 E-value: 8.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 23 GAAFISIGFSYAFPKAITVFFkeIQQIFNASyseIAWISSIMLAVMYAGG---PVSSVLVNRYGSR-----PVVITGGLL 94
Cdd:COG2211 16 GLGDLGLNLAFGLLSAYLLYF--YTDVLGLS---AALVGLILLVARLWDAitdPLIGALSDRTRTRwgrrrPWILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 95 CCLGMV----SASFSTNVVELYLTVGFIG-GIGLAFNLQPALTIIGKYF--YKKRPMANG----LAMAGSPVFLSTLAPF 163
Cdd:COG2211 91 LALSFVllftAPDLSPTGKLIYALVTYLLlGLAYTLVNIPYSALGAELTpdYEERTRLSSwrfaFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 164 NQYLF--NTFGWKGSFLILGGILLnscVAGSLMRpvgpkqtnkaknkIGIKadEAEAKKSHKKSLSEKInkyldFSLFKH 241
Cdd:COG2211 171 VAAFGgdAALGYRLTALIFAVLGL---LAFLLTF-------------FGTK--ERPVPEEEKVSLKESL-----KALLKN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 242 RGFLIYLSGNVIMFLGFFAPIIFLAPYAKDK-GIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMF 320
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAK-RFGKKKA---FIIGLLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 321 TGVCHLLCPLA--EDYTSLVLYAIFFGLGFGSVSSVLFETLMDLV-------GAQRFSSAVGLVTIVECCPVLLGPPLAG 391
Cdd:COG2211 304 AALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAG 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2124478937 392 KLVDETG-------------QYKYMYIACGAIVFLSSVWLLIGnainYRLlaKEKKLAEAEKKIHK 444
Cdd:COG2211 384 LLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLF----YPL--TRERHAEIRAELAA 443
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-420 |
1.18e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.90 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 43 FKEIQQIFNASYSEIAWISSIMLAVMYAG----GPVSSvlvnRYGSRPVVITGGLLCCLGMVSASFSTNvVELYLTVGFI 118
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSD----RFGRRPVLLAGLLLFILASLLCALASS-IEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 119 GGIGLAFNLQPALTII-GKYFYKKRPMANGLAMAG---SPVflstLAP-FNQYLFNTFGWKGSFLILGGILLnSCVAGSL 193
Cdd:cd17320 97 QGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIlaiAPA----LAPlLGGLLLLFFGWRAIFVFLALLGL-LLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 194 MRpvgPKQTNKAKNKigikadeaeakkshKKSLSEKINKYldFSLFKHRGFLIYLSGNVIMFLGFF-----APIIFLAPY 268
Cdd:cd17320 172 LF---LPETLPEEKR--------------KPLLSSLLRAY--KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 269 akDKGIDEYSAAFLLSIMAFVdmfarpsVGLIANSRFIR---PRIQYFFSFAIMFTGVCHLL---CPLAEDYTSLVLYAI 342
Cdd:cd17320 233 --GLSPAQFGLLFALNAIALI-------LGSLLNGRLVRrfgPRRLLRLGLLLLLAAALVLLlaaLLGGLSLWPLVAPLF 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2124478937 343 FFGLGFGSVSSVLFETLMDLVGaQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQykYMYIACGAIVFLSSVWLLI 420
Cdd:cd17320 304 LIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGTAL--PMGLLILVLGLLALLLLIL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-184 |
6.31e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.75 E-value: 6.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 18 GWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELyLTVGFIGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGS 176
Cdd:TIGR00895 95 FTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
....*...
gi 2124478937 177 FLIlGGIL 184
Cdd:TIGR00895 174 FYV-GGIA 180
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
20-414 |
2.14e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 20 VVVGAAFISIGFSYAFPkAITVFFKEIqqifNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGM 99
Cdd:cd17477 1 LLLSVALLGLGSGLLLP-LLSLRLERE----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 100 VSASFSTNVVeLYLTVGFIGGIGLAFNL---QPAL----------TIIGKYFykkrpMANGLAMAGSPVFLStlapfnqy 166
Cdd:cd17477 76 LLLALTDSPW-VWFLLRFVMGIGLAGLFvvsESWLnalatnenrgRVLGLYS-----TVLGLGFALGPLLLA-------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 167 LFNTFGWKgSFLILGGILLNSCVAGSLMRPVGPkqtnkaknkigikadeaEAKKSHKKSLSEKInkyldfslfkhRGFLI 246
Cdd:cd17477 142 LVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAP-----------------EIEEAESISLRRLL-----------RIAPL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 247 YLSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIQYFFSFAIMftgVCHL 326
Cdd:cd17477 193 ALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD-RFDRRRVLLGCALLGA---LAAL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 327 LCPLAeDYTSLVLYAIFF--GLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETG-QYKYM 403
Cdd:cd17477 269 LLPLV-PGLPLALLVLLFlwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGpHGLFL 347
|
410
....*....|.
gi 2124478937 404 YIACGAIVFLS 414
Cdd:cd17477 348 FLAAVALLFLL 358
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-376 |
7.31e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.49 E-value: 7.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 45 EIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVveLYLTVG-FIGGIGL 123
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL--AFLIAArALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 124 AFNLQPALTIIGKYFY-KKRPMA---NGLAMAGSPVFLSTLAPFnqyLFNTFGWKGSFLILGGILLnscvagslmrpvgp 199
Cdd:cd17321 99 AAIMPASLALIAATFPgERRGRAlglWGAVVGIGAALGPLLGGL---LLELFGWRWIFLINVPIGL-------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 200 kqtnkaknkigikadeaeakkshkkslsekinkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-KGIDEYS 278
Cdd:cd17321 162 ------------------------------------VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 279 AAFLLSIMAFVDMFARPSVGLIANsRFIrPRIQYFFSFAIMFTGVCHL-LCPLAEDYTSLVLYAIFFGLGFGSVSSVLFE 357
Cdd:cd17321 206 AGLALLPLALAMLVAAPLAGRLAD-RFG-PRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTN 283
|
330
....*....|....*....
gi 2124478937 358 TLMDLVGAQRFSSAVGLVT 376
Cdd:cd17321 284 AALSSVPKEKAGAASGILN 302
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-420 |
8.99e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 8.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 248 LSGNVIMFLGFFAPIIFLAPY-AKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMFTGVCHL 326
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGRRRV---LLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 327 LCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIA 406
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 2124478937 407 CGAIVFLSSVWLLI 420
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-416 |
1.44e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 46 IQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSAsFSTNVVELYLTVGFIGGIGLAF 125
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI-FATPSIYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 126 NLQPALTIIGKYFYKKRPMANGLaMAGSPVFLSTLAPF--NQYLFNTFGWKGSFLILGGILLnsCVAGSLMRPVGPKQTN 203
Cdd:cd17333 101 LDTGANTFVGALFEESSATRLNV-LHGFFGLGALIGPLiaTSLLTSELSWSWAYLIIGLIYL--LLAILILLTLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 204 KAKNKIGIKADEAEAKKSHkkslseKINKYLDFSLFkhrgFLIYLSGNVIMflgffapIIFLAPYAKDK-GIDEYSAAFL 282
Cdd:cd17333 178 ARNPQQSVGAFSASASRLL------RNPSIILGALA----LFLYVGAETAF-------SSWVPSYLVEKkHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 283 LSIMAFVDMFARPSVGLIanSRFIRPRIQYFFSfaimFTGVCHLLCPLAEDYTSLVLYAIFFGLGFGsvSSVLFETLMDL 362
Cdd:cd17333 241 LSGFWVGITIGRLLGGPI--SRRIKPHTLLVLS----GSGALLGLLILLLAPTLVVGLVATALLGLF--MAALFPTILSL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 363 vGAQRF----SSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYI--ACGAIVFLSSV 416
Cdd:cd17333 313 -GISNLpyakGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLitILYAIIFVLAL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
253-420 |
2.21e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 253 IMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSRFIRPRIQYFFSFAImftgVCHLLCPLAE 332
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI----LGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 333 DYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETG-QYKYMYIACGAIV 411
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwRAAFLAIAVLALL 165
|
....*....
gi 2124478937 412 FLSSVWLLI 420
Cdd:cd17324 166 AALLLWRLL 174
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
244-420 |
2.41e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.74 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 244 FLIYL-SGNVIMFLGFFAPIIflapyAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqyfFSFAIMFTG 322
Cdd:TIGR00895 23 FLIMLmDGYDLAAMGFAAPAI-----SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD-RIGRRRV---LLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 323 VCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKY 402
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
170
....*....|....*...
gi 2124478937 403 MYIacGAIVFLSSVWLLI 420
Cdd:TIGR00895 174 FYV--GGIAPLLLLLLLM 189
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
53-416 |
4.19e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 4.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 53 SYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELyLTVGFIGGIGLAFNLQPALT 132
Cdd:cd06180 32 SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL-LALRFLAGAASAFVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 133 IIGKYFYKKRPMA--------NGLAMAGSpvflSTLAPFNQYLFNtfGWKGSFLILGGILLNSCVAGSLMRPVGPkqtnk 204
Cdd:cd06180 111 LVLHHATAAGRGHligllfagVGLGIALS----GLLVPAGLGGGL--SWRAGWLALALLSAVLLLLSFLLLRRGP----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 205 aknkigikADEAEAKKSHKKSlsekinkyldfslFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLls 284
Cdd:cd06180 180 --------SAPTEASAAESAP-------------GLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLL-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 285 iMAFVDMFARPSVGLianSRFIRPRIQYFFSFAIMF--TGVCHLLCPLAEDYTSLVLYAIFFGLGF-GSVSSVLFETLMd 361
Cdd:cd06180 237 -WSLFGLAAVPSCFL---WGALSDRWGTRRALAANLlvQAVGVLLPLLSPGPAGLVLSAVLFGGTFmAITALVMALARE- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2124478937 362 lVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGQYKYMYIACGAIVFLSSV 416
Cdd:cd06180 312 -LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-420 |
5.70e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 5.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPkAITVFFKeiqQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLG 98
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWP-FMAIYLH---QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 99 MVSASFSTNVvelYLTVGFIGGIGLAFNL-QPAL-TIIG--------KYFYKKRPMANGLAMAGSPVFLSTLApfnQYLF 168
Cdd:cd17329 79 FALLGFAHSP---WLFAIALVLTGFGGGLfEPASeAMIAdvttpenrTRAFSLLYWAINLGVAIGPLLGGLLL---LYSF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 169 NTFgwkgsFLILGGILLnscVAGSLMrpvgpkqtnkaknKIGIKADEAEAKKSHKKSLSEKINkyldfSLFKHRGFLIYL 248
Cdd:cd17329 153 RLL-----FLAAAVLFL---LAALVL-------------LFLLPETRPKRRAAEKTEILRGYK-----IVLRDRAFLLFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 249 SGNVIMFLGFFAPIIFLAPYAKDKGIDEYSA-AFLLSIMAFVDMFARPSVglianSRFI-RPRIQYFFSFAIMFTGVCHL 326
Cdd:cd17329 207 LASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPV-----ARLVeRFRLRKILMIGILLFAIGFA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 327 LCPLAEDYTSLVLYAIFFGLG---FGSVSSVLFETLMDLVGAQRFSSAVGLVTIVEccpVLLGPPLAGKLVDeTGQYKYM 403
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLD-LLGPGLP 357
|
410
....*....|....*..
gi 2124478937 404 YIACGAIVFLSSVWLLI 420
Cdd:cd17329 358 WLILAALGLIAAALLLG 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-196 |
6.84e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.41 E-value: 6.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFpkaITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSR--PVVITGGLLCC 96
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 97 LGMVSASFSTNVVeLYLTVGFIGGIGLAFNLQPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKG 175
Cdd:COG2271 260 LALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 2124478937 176 SFLILGGILLNSCVAGSLMRP 196
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-416 |
7.22e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 7.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 46 IQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVeLYLTVGFIGGIGLAF 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW-LLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 126 NLQPALTIIGKYFYKKRPMANGLAMAG-------SPVFLStlapfnqYLFNTFGWKGSFLILGGILLNSCVAGSLMRPVG 198
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 199 PKQTNKAKNKIGIKAdeaeakkshkkslsekinkyldfSLFKHRGFLIYLsgNVIMFL---GFFAPIIFLAPYAKDKGID 275
Cdd:cd17478 174 KPEAKKAAAKSSARS-----------------------TLKGVWRALLLL--LIIVFLrswVLSSLTTFLPFYLVQRGYS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 276 EYSAAFLLSIMAFVDMFARPSVGLIANsRFIRPRIqYFFSFAIMFtgVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVl 355
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSD-RFGRRRV-IIASLLLAA--PFLLLFLLTPGIWSYILLVLAGFLLFASFPVT- 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2124478937 356 fetlmdLVGAQRF-----SSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSV 416
Cdd:cd17478 304 ------VVLAQELlpgnvGLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGAL 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
55-194 |
1.76e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.89 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 55 SEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTvGFIGGIGLAFNLQPALTII 134
Cdd:cd17365 34 AQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-RFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2124478937 135 GKYFYKK-RPMANGLAMAGSPV---FLSTLAPFnqyLFNTFGWKGSFLILG--GILLNSCVAGSLM 194
Cdd:cd17365 113 SEYAPARrRSLAVTLMFCGYPLgaaLGGFLAAA---LIPAFGWRSVFLLGGvpPLILLPLLRGTLL 175
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
250-424 |
1.86e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 250 GNVIMFLGFFAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIANSrfIRPRIqyFFSFAIMFTGVCHLLCP 329
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR--FGRRR--VLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 330 LAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGA 409
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGL 172
|
170
....*....|....*
gi 2124478937 410 IVFLSSVWLLIGNAI 424
Cdd:COG2271 173 PGLLLALLRFWLLAL 187
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-416 |
2.26e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.50 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 46 IQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTVGfIGGIGLA- 124
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA-LQGIGGAv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 125 FNLqpALTIIGKYFYKKR-PMANGL--AMAGSPVFLStlAPFNQYLFNTFGWKGSFLILGGIllnsCVAGSLMRPVgpkq 201
Cdd:cd17504 101 FPL--AFALVREEFPPERvPVAQGIlsATFGIGAGIG--LPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVPL---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 202 tnkaknkigikadeaeakkshkkslsekinkyLDFSLFKHRGFLIYLSGNVIMFLGFFA-----PIIFLAPYAKDKGIDE 276
Cdd:cd17504 169 --------------------------------IDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 277 YSAAFLLSIMAFVDMFARPSVGLIANSrfIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSLVLYAIfFGLGFGSVSSVLF 356
Cdd:cd17504 217 TEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL-IGIGLGLAFASLP 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124478937 357 ETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKL------------VDETGQYKYMYIACGAIVFLSSV 416
Cdd:cd17504 294 NIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-420 |
2.64e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 57 IAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASF-----STNVVELYLTVgFIGGIGLAFNlQPAL 131
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLA-FLLGIASAFF-GPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 132 T-----IIGKyfyKKRPMANGL---AMAGSPVFLSTLAPFnqyLFNTFGWKGSFLILGGILLnsCVAGSLMRpvgpkqtn 203
Cdd:cd06173 114 QallpeLVPK---EQLVRANALnslATQLARIIGPALGGL---LVALLGPGGAFAINALSFL--LSALLLLF-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 204 kaknkigIKADEAEAKKSHKKSLSEKINKYLDFslFKHRGFLIYLSGNVIMFLGFFAPIIFLAP-YAKDKGIDEYSAAFL 282
Cdd:cd06173 178 -------IRRPPPAAPGESSSLLLRDLREGLRY--LRRSPLLRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 283 LSIMAFVDMFArpsVGLIANSRFIRPRIQYFFSFAIMFTGVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDL 362
Cdd:cd06173 249 LLAAFGVGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2124478937 363 VGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSVWLLI 420
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
43-263 |
2.76e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 49.51 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 43 FKEIQQIFNASYSEIAWISSIMLAVMYAG----GPvssvLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELyLTVGFI 118
Cdd:PRK11043 29 FKAIQADLQTSASAVSASLSLFLAGFALGqllwGP----LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL-LVLRFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 119 GGIGL---AFNLQpALtIIGKYFYKKrpmANGLAMAGSP-VFLS-TLAP-FNQYLFNTFGWKGSFLILGGI--LLnscVA 190
Cdd:PRK11043 104 QAVGVcsaAVIWQ-AL-VIDRYPAQK---ANRVFATIMPlVALSpALAPlLGAWLLNHFGWQAIFATLFAItlLL---IL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 191 GSLMRPVGPKQTNKAKNKIGIKadeaeakkshkkslsekinkyldfSLFKHRGFliylSGNVIMF----LGFFA-----P 261
Cdd:PRK11043 176 PTLRLKPSKKARKQSQDALTFK------------------------QLLKSKTY----LGNVLIFaacsAAFFAwltgsP 227
|
..
gi 2124478937 262 II 263
Cdd:PRK11043 228 FI 229
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
72-181 |
5.03e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.10 E-value: 5.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 72 GPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTvGFIGGIGLAFNLQPALTIIGKYF-YKKRPMANGLAM 150
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYpPEERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|.
gi 2124478937 151 AGSPVFLSTLAPFNQYLFNTFGWKGSFLILG 181
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-351 |
6.81e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 6.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 45 EIQQIFNASYSEIAWissiMLAVMYAGGPVSSV----LVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTVGFIGG 120
Cdd:cd17341 24 VIRDDLGLSTSQIGL----LVAIPVLAGALLRLpygfLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 121 IGLAfNLQPALTIIGKYFYKKRP-----MANGLAMAGSPV---FLSTLAPFNQYLFNTFGWKGSFLILGGILLNSCVAGS 192
Cdd:cd17341 100 FAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 193 LMRPVGPKQtnkaknkigiKADEAEAKKSHKKSLSEKINKYLdfslfkhrgFLIYlsgnVIMFLGFFAPIIFLAPYAKDK 272
Cdd:cd17341 179 LFGDDLPTG----------KASALEFLKVQLAVLKNYRTWIL---------SLLY----GVTFGSFVGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 273 -GIDEYSAAFLLSIMAFVDMFARPSVGLIANsrFIRPRIQYFFSFAIM--FTGVCHLLCPLAED-----YTSLVLYAIFF 344
Cdd:cd17341 236 fGLPLVTAGILAALFPLAGALARPAGGWLSD--RFGGRRRLWWLFIVMtiGAALLSLSLPTSGTnlvlfLALFVALGLGA 313
|
....*..
gi 2124478937 345 GLGFGSV 351
Cdd:cd17341 314 GAGNGSV 320
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-134 |
7.08e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.94 E-value: 7.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 22 VGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVS 101
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250
|
90 100 110
....*....|....*....|....*....|....*
gi 2124478937 102 ASFSTNVVELYLTVG--FIGGIGLAFNLQPALTII 134
Cdd:cd17321 251 LALLGADSSVWLLLPglVLLGLGLGLFATPLTNAA 285
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
244-418 |
5.29e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 244 FLIYLSgnvimfLGFFAPiiFLAPYAKDKGIDEYSAAFLLSIMAFVDMFARPSVGLIAnSRFIRPRIQYFFSFAIMFTGV 323
Cdd:cd17335 7 FFFFAA------LGSLLP--FLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALA-DRFGKRKALLLLSLLAAVLFF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 324 CHLLCPLAEDYTSL---VLYAIFFGLGFGSVSSVLFETL---MDLVGAQRFSSAVGLVtiveccpvlLGPPLAGKLVDET 397
Cdd:cd17335 78 LSLFFVAQIFWLLLllvILGAFFSAPVVPLVDSITLQYLgeeRERYGKQRLWGSIGFG---------IAALLVGILIDRS 148
|
170 180
....*....|....*....|....*..
gi 2124478937 398 GQYK------YMYIACGAIVFLSSVWL 418
Cdd:cd17335 149 STYKnytiafYVFAVLMLLALLLALKF 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
242-419 |
9.22e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 9.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 242 RGFLIYLSGNVIMFLGFFApIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFArpsvGLIANSRFIRPRIQYFFSFAIMFT 321
Cdd:cd17370 200 KAFWLYLLAVALFALGNFS-FAFLILRAQELGLSAALIPLLYALFNLVYALA----AYPAGRLSDRIGRKKLLILGYLSL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 322 GVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLAGKLVDETGqYK 401
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
|
170
....*....|....*...
gi 2124478937 402 YMYIACGAIVFLSSVWLL 419
Cdd:cd17370 354 AAFLFSAVLALIALLLLL 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-191 |
1.16e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.11 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPKAITVFFKEIQQI-FNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIGGIGLAFNLQpaltiigkyfykkrPMANGLAMAGSPVFLSTLAPFNQyLFNTFGWKGSF 177
Cdd:cd17504 260 GLLLLALLHSSLWALVVALLLIGIGLGLAFA--------------SLPNIVVESVPPDRTGIATGMNT-VLRTIGSAIGP 324
|
170
....*....|....
gi 2124478937 178 LILGGILLNSCVAG 191
Cdd:cd17504 325 AIAGAILTTYTVSI 338
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
219-420 |
1.31e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 219 KKSHKKSLSEKINKYldFSLFKHRgFLIYLS--GNVIMFLGFFAPIIFLAPYAKDKGideySAAFLLSIMAFVDMFARPS 296
Cdd:cd17490 173 ERREKKPVLTELKEL--LSVLKDK-KLLFFSllAILQQMITFSTTFGFTPLIAKQLG----ASSFQLGLLSIIYLLPNAL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 297 VGLIANSRFIRPRIQY---FFSFAIMftGVCHLLCPLAEDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVG 373
Cdd:cd17490 246 ASLLSGTLFYKKLGERntiIIGFLLL--GAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMG 323
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2124478937 374 LVTIVECCPVLLGPPLAGKLVDETGqYKYMYIACGAIVFLSSVWLLI 420
Cdd:cd17490 324 FFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
19-185 |
2.39e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSIMLAvMYAGGP-VSSVLVNRYGSRPVVITGGLLCCL 97
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 98 GMVSASFSTNVVELYLTVGFIG---GIGLAfnlqPALTIIGKYFYKK-RPMANGLAMAGSPVFLSTLAPFNQYLFNTFGW 173
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASYYGW 156
|
170
....*....|..
gi 2124478937 174 KGSFLILGGILL 185
Cdd:cd17312 157 RAAFLVPGIVGL 168
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
259-419 |
2.49e-04 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 43.37 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 259 FAPIIFLAPYAKDKGIDEYSAAFLLSIMAFVDMFArpsvglianSRFIRPRIQ------YFFSFAIMFTGVChLLCPLAE 332
Cdd:PRK10213 37 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFA---------SLFITQTIQatdrryVVILFAVLLTLSC-LLVSFAN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 333 DYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLaGKLVDETGQYKYMYIACGAIVF 412
Cdd:PRK10213 107 SFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPL-GSFLGELIGWRNVFNAAAVMGV 185
|
....*..
gi 2124478937 413 LSSVWLL 419
Cdd:PRK10213 186 LCIFWII 192
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
22-194 |
5.01e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.25 E-value: 5.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 22 VGAAFISI---GFSYAFPKAITVFFKE-IQQIFNASY------SEIAWISSIMLAVMYAGG----PVSSVLVNRYGSRPV 87
Cdd:cd17357 2 VIVAFGGSfqfGYNIGVVNAPQEVFKEfINDTLVDRYglnlsdSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 88 VITGGLLCCLG--MVSASFSTNVVELYLTVGFIGGIglafnlqpaltiigkyfykkrpmANGLAMAGSPVFLSTLAPFNq 165
Cdd:cd17357 82 LLISNALLVVSslLMFLSKSAKSPELLIFGRFLVGI-----------------------ACGLSTGFVPMYLQEISPSE- 137
|
170 180 190
....*....|....*....|....*....|
gi 2124478937 166 ylfntfgWKGSFLILGGILLN-SCVAGSLM 194
Cdd:cd17357 138 -------LRGALGSLTQIGVTlGILLGQVF 160
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
22-133 |
2.31e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 22 VGAAFISIGFSyAFPKAITVFFKEIqqifnaSYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVS 101
Cdd:cd17489 201 LILFLASIAYG-AISTFLPLYAAER------GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
90 100 110
....*....|....*....|....*....|...
gi 2124478937 102 ASFSTNVVELYLTVGFIG-GIGLAFNLQPALTI 133
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGlGFGLLFPALQALAV 306
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
45-128 |
2.67e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 45 EIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNVVELYLTV----GFIGG 120
Cdd:cd17393 24 AIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALflfgAANGA 103
|
....*...
gi 2124478937 121 IGLAFNLQ 128
Cdd:cd17393 104 LDVAMNAQ 111
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-185 |
3.49e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 19 WVVVGAAFISIGFSYAFPKAITVFFKEIqqiFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLG 98
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDV---LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 99 MVSASFSTNVVELYLTVGFIG-GIGLAFNLqpALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQYLFNTFGWKGSF 177
Cdd:COG0738 290 LLLALLAPGPWLALIGLALVGlGLSLMFPT--IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
....*...
gi 2124478937 178 LILGGILL 185
Cdd:COG0738 368 LVPLVCYL 375
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
45-398 |
3.64e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 45 EIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFsTNVVELYLTVGFIG-GIGL 123
Cdd:cd17339 24 EIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSL-GGIALLFLGTALAGaGIAV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 124 AFNLQPALtiIGKYFYKKRPMANGL---AMAGSPVFLSTLA-PFNQYLFntFGWKGSFLILGGI-LLNSCVAGSLMRpvg 198
Cdd:cd17339 103 GNVLLPSL--IKRDFPRRVGLMTGLyttSMNLGAALASGLSvPLAQALG--GGWRGALAIWALPaLLALLIWLPQLR--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 199 pkqtnkaknkiGIKADEAEAKKSHKKSLsekinkyldfsLFKHRGFLiylsgnVIMFLG-----FFAPIIFLAPYAKDKG 273
Cdd:cd17339 176 -----------RRKRAAAAAAPLTKISV-----------WRSPLAWQ------VTLFMGlqsllFYTLMAWLPTILIDAG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 274 IDEYSAAFLLSIMAFVDMFARPSVGLIAnSRFIRPRIQYFFSFAIMFTGVCHLLCPLAedyTSLVLYAIFFGLGFGSvss 353
Cdd:cd17339 228 LSAATAGWLLSLFQLVGIPASLLVPILA-TRLKNQRPIVVLLAVLFIIGVLGLLFAPT---ALALLWAVLLGLGGGA--- 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2124478937 354 vLFETLMDLVGaQRFSS---AVGLVTIVECCPVLL---GPPLAGKLVDETG 398
Cdd:cd17339 301 -AFSLALTLIS-LRSSDpaeAAALSGMAQSVGYLLaalGPLLFGVLHDLTG 349
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
50-125 |
3.83e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 39.54 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 50 FNASyseIAWISSIMLAVMYAG-------GPVSsvlvNRYGSRPVVITGGL---LCCLgmvsASFSTNVVELYLTVGFIG 119
Cdd:PRK15402 43 FNAG---AEWVPTSMTAYLAGGmflqwllGPLS----DRIGRRPVMLAGVAffiLTCL----AILLAQSIEQFTLLRFLQ 111
|
....*.
gi 2124478937 120 GIGLAF 125
Cdd:PRK15402 112 GIGLCF 117
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
58-134 |
4.17e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.10 E-value: 4.17e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2124478937 58 AWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLCCLGMVSASFSTNvVELYLTVGFIGGIGLAFNLQPALTII 134
Cdd:cd17317 28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-YELFLVLRFLVGVTSAGIFTVGFVLG 103
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-190 |
4.71e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 17 WGWVVVGAAFISIGFSYAFPKAITVFFKEIQQIFNASYSEIAWISSI----MLAVMYAGGPVSSVLVnRYGSRPVVITGG 92
Cdd:cd17319 177 YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIpflaGAIGMILGGRLSDRLL-RGARRLVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 93 LLCCLGMVSASFSTNvveLYLTVGF--IGGIGLAFNLQPALTIIGKYFYKKRPMANGLAMAGSPVFLSTLAPFNQ-YLFN 169
Cdd:cd17319 256 LLAAVGLLLAYLTTS---PVVAVILlsLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIgYLVD 332
|
170 180
....*....|....*....|..
gi 2124478937 170 TFG-WKGSFLILGGILLNSCVA 190
Cdd:cd17319 333 ATGsYTAAFLFLAAVALLAALL 354
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
16-355 |
9.55e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 9.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 16 GWGWVVVGAAFISIGFSYAFpkaitvFFKEIQQIFNASYSEIAWISSIMLAVMYAGGPVSSVLVNRYGSRPVVITGGLLC 95
Cdd:pfam00083 13 GYDTGVIGAFLTLIDFFKNF------GLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 96 CLGMV--SASFSTNVVELYLTVGFIGGIGLafnlqpaltiigkyfykkrpmanGLAMAGSPVFLSTLAP---------FN 164
Cdd:pfam00083 87 VIGAVlqGAAKGKWSVYQLIVGRVLVGIGV-----------------------GGASVLAPMYISEIAPkklrgalgsLY 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 165 Q--------------YLFNTF----GWKGSF---LILGGILLnscvAGSLMRPVGP------KQTNKAKNKI-------G 210
Cdd:pfam00083 144 QlaitfgillayifgLGLNKTsnsdGWRIPLglqLVPALLLI----IGLLFLPESPrwlvekGRLEEAREVLaklrgvpD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 211 IKADEAEAKKSHKKSLSEKINKYLD-FSLFKHRGFLIYLSGNVIM--FLGFFApIIFLAPYAKDK-GIDEYSAA-FLLSI 285
Cdd:pfam00083 220 VDRELDEIKDSLEAGQEAEKASWKElFSTKTRRQRLLIGVMLQIFqqLTGINA-IFYYSTTIFENlGLSDSFLVtIIVGV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124478937 286 MAFVDMFarpsVGLIANSRFIRpRIQYFFSFAIM-----FTGVCHLLCPLAEDY------TSLVLYAIFFGLGFGSVSSV 354
Cdd:pfam00083 299 VNFVFTF----IAIFLVDRFGR-RPLLLLGAAGMaicfvILGIVALLGVSKSDWagivaiVFIALFIAFFAMGWGPVPWV 373
|
.
gi 2124478937 355 L 355
Cdd:pfam00083 374 I 374
|
|
| |
